The Value of Assessing Myocardial Deformation at Recovery after Dobutamine Stress Echocardiography
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Background: The purpose of this study was to evaluate whether performing an assessment of myocardial deformation usingspeckle tracking imaging during the recovery period after dobutamine stress echocardiography (DSE) allows detection ofsignificant coronary artery disease (CAD) in patients with chest discomfort. Methods: DSE and coronary angiography were performed in 44 patients with chest discomfort. The mean global longitudinalpeak systolic strain (GLS) was measured at rest, at low stress (dobutamine infusion rate of 10 μg/kg/min) and at recovery (5 minafter cessation of dobutamine infusion) of DSE using automated function imaging with apical views. Fractional flow reserve(FFR) was also performed in patients with intermediate coronary stenosis. CAD was defined as having a ≥ 70% diameter stenosison coronary angiography or as having a FFR < 0.8. Patients were divided two groups based on the absence or presence of CAD[CAD (-) group vs. CAD (+) group]. Results: There were no significant differences in the clinical characteristics and results of conventional echocardiographybetween the two groups. GLS at recovery was lower in the CAD (+) group than in the CAD (-) group (-18.0 ± 3.4% vs. -21.0 ±1.9%, p = 0.003). The optimal cutoff of GLS at recovery for detection of CAD was -19% (sensitivity of 70.6%, specificity of83.3%). Conclusion: Assessment of GLS at recovery of DSE is a reliable and objective method for detection of CAD. This finding maysuggest that systolic myocardial stunning remains even after recovery of wall motion abnormalities in patients with CAD.
Abstract
Background: The purpose of this study was to evaluate whether performing an assessment of myocardial deformation usingspeckle tracking imaging during the recovery period after dobutamine stress echocardiography (DSE) allows detection ofsignificant coronary artery disease (CAD) in patients with chest discomfort. Methods: DSE and coronary angiography were performed in 44 patients with chest discomfort. The mean global longitudinalpeak systolic strain (GLS) was measured at rest, at low stress (dobutamine infusion rate of 10 μg/kg/min) and at recovery (5 minafter cessation of dobutamine infusion) of DSE using automated function imaging with apical views. Fractional flow reserve(FFR) was also performed in patients with intermediate coronary stenosis. CAD was defined as having a ≥ 70% diameter stenosison coronary angiography or as having a FFR < 0.8. Patients were divided two groups based on the absence or presence of CAD[CAD (-) group vs. CAD (+) group]. Results: There were no significant differences in the clinical characteristics and results of conventional echocardiographybetween the two groups. GLS at recovery was lower in the CAD (+) group than in the CAD (-) group (-18.0 ± 3.4% vs. -21.0 ±1.9%, p = 0.003). The optimal cutoff of GLS at recovery for detection of CAD was -19% (sensitivity of 70.6%, specificity of83.3%). Conclusion: Assessment of GLS at recovery of DSE is a reliable and objective method for detection of CAD. This finding maysuggest that systolic myocardial stunning remains even after recovery of wall motion abnormalities in patients with CAD.
참고문헌 (29)
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