Gender Differences in Clinical Profiles of Stress-Induced Cardiomyopathy
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Background: Although stress-induced cardiomyopathy (SCMP) is reported to be more common in women, little is knownabout gender differences in patients with SCMP. The aim of the study was to describe clinical features of patients with SCMP according to gender. Methods: One hundred and three patients diagnosed with definite SCMP at a single tertiary institute from January 1997 toAugust 2014 were enrolled. SCMP was more common in women than in men. Results: Age at presentation was not significantly different between the two groups (p = 0.758). Preceding physical stress, especially acute medical illness, was more common in male patients (p = 0.014), whereas emotional stress was more common in female patients (p = 0.016). Severity of medical illness classified by the Acute Physiology and Chronic Health Evaluation(APACHE) II score at the time of SCMP diagnosis was not significantly different between men and women (p = 0.752). Clinicalcharacteristics, including symptoms, laboratory and electrocardiographic findings, were similar. However, pump failure was moresevere in men (p = 0.024). Clinical outcomes were not statistically different (p = 0.220). Preceding physical stress and lower leftventricular systolic function after 2 months were independent risk factors for all-cause mortality for both genders. Women with anAPACHE II score ≥ 15 and men with reduced left ventricular ejection fraction after 2 months had a greater risk of poor prognosis. Conclusion: SCMP was more common in female patients. Female patients more commonly experienced preceding emotionalstress, whereas physical stress was more common in male patients. Systolic dysfunction was more severe in men. Long-term clinical outcomes appeared to be similar between men and women.
Abstract
Background: Although stress-induced cardiomyopathy (SCMP) is reported to be more common in women, little is knownabout gender differences in patients with SCMP. The aim of the study was to describe clinical features of patients with SCMP according to gender. Methods: One hundred and three patients diagnosed with definite SCMP at a single tertiary institute from January 1997 toAugust 2014 were enrolled. SCMP was more common in women than in men. Results: Age at presentation was not significantly different between the two groups (p = 0.758). Preceding physical stress, especially acute medical illness, was more common in male patients (p = 0.014), whereas emotional stress was more common in female patients (p = 0.016). Severity of medical illness classified by the Acute Physiology and Chronic Health Evaluation(APACHE) II score at the time of SCMP diagnosis was not significantly different between men and women (p = 0.752). Clinicalcharacteristics, including symptoms, laboratory and electrocardiographic findings, were similar. However, pump failure was moresevere in men (p = 0.024). Clinical outcomes were not statistically different (p = 0.220). Preceding physical stress and lower leftventricular systolic function after 2 months were independent risk factors for all-cause mortality for both genders. Women with anAPACHE II score ≥ 15 and men with reduced left ventricular ejection fraction after 2 months had a greater risk of poor prognosis. Conclusion: SCMP was more common in female patients. Female patients more commonly experienced preceding emotionalstress, whereas physical stress was more common in male patients. Systolic dysfunction was more severe in men. Long-term clinical outcomes appeared to be similar between men and women.
참고문헌 (27)
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