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Impact of Mindfulness Based Stress Reduction Therapy on Myocardial Function and Endothelial Dysfunction in Female Patients with Microvascular Angina

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Background: Mindfulness-based stress reduction (MBSR) is a structured group program that employs mindfulness meditation to alleviate suffering associated with physical, psychosomatic, and psychiatric disorders. In this study, we investigate the impactof MBSR on left ventricular (LV) and endothelial function in female patients with microvascular angina. Methods: A total of 34 female patients (mean age 52.2 ± 13.8 years) diagnosed with microvascular angina underwent a MBSRprogram with anti-anginal medication for 8 weeks. The global longitudinal strain (GLS) of the LV was used as a parameter to assess myocardial function and reactive brachial flow-mediated dilatation (FMD) was used to assess endothelial function. Symptomswere analyzed by the Symptom Checklist 90 Revised to determine emotional stress. Changes in GLS and FMD between baselineand post-MBSR were analyzed. Results: After 8 weeks of programmed MBSR treatment, stress parameters were significantly decreased. In addition, GLS(-19.5 ± 2.1% vs. -16.6 ± 2.5%, p < 0.001) and reactive FMD significantly improved (8.9 ± 3.0% vs. 6.9 ± 2.6%, p = 0.005) afterMBSR compared to baseline. The changes in GLS correlated to changes in FMD (r = 0.120, p = 0.340) and with the changes inmost stress parameters. Conclusion: MBSR has beneficial impacts on myocardial and endothelial function in female patients with microvascular angina.

Abstract

Background: Mindfulness-based stress reduction (MBSR) is a structured group program that employs mindfulness meditation to alleviate suffering associated with physical, psychosomatic, and psychiatric disorders. In this study, we investigate the impactof MBSR on left ventricular (LV) and endothelial function in female patients with microvascular angina. Methods: A total of 34 female patients (mean age 52.2 ± 13.8 years) diagnosed with microvascular angina underwent a MBSRprogram with anti-anginal medication for 8 weeks. The global longitudinal strain (GLS) of the LV was used as a parameter to assess myocardial function and reactive brachial flow-mediated dilatation (FMD) was used to assess endothelial function. Symptomswere analyzed by the Symptom Checklist 90 Revised to determine emotional stress. Changes in GLS and FMD between baselineand post-MBSR were analyzed. Results: After 8 weeks of programmed MBSR treatment, stress parameters were significantly decreased. In addition, GLS(-19.5 ± 2.1% vs. -16.6 ± 2.5%, p < 0.001) and reactive FMD significantly improved (8.9 ± 3.0% vs. 6.9 ± 2.6%, p = 0.005) afterMBSR compared to baseline. The changes in GLS correlated to changes in FMD (r = 0.120, p = 0.340) and with the changes inmost stress parameters. Conclusion: MBSR has beneficial impacts on myocardial and endothelial function in female patients with microvascular angina.

참고문헌 (31)

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