Dietary and modifiable factors contributing to hyper-LDL-cholesterolemia prevalence in nationwide time series data and the implications for primary prevention strategies
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BACKGROUND/OBJECTIVES: A number of studies examined secular trends in blood lipid profiles using time series data of national surveys whereas few studies investigated individual-level factors contributing to such trends. The present study aimed to examine secular trends in dietary and modifiable factors and hyper-LDL-cholesterolemia (HC) prevalence and evaluate their associations using time series data of nationwide surveys. SUBJECTS/METHODS: The study included 41,073 Korean adults aged ≥ 30 years from the 2005, 2007-2009, 2010-2012, 2013-2015, and 2016 Korea National Health and Nutrition Examination Surveys. Stepwise logistic regression analysis was performed to select significant factors associated with HC, which was defined as serum LDL cholesterol levels ≥130 mg/dL. RESULTS: The following factors showed a positive association with HC (P < 0.05): for men having higher body mass index (BMI), being married, having an office job, and consuming higher dairy and vegetable oil products; for women having higher age or BMI, having no job or a non-office job, not in a low-income household, and consuming higher dairy products. In the given model, the 2016 survey data showed that a 2 kg/m2 reduction in BMI of obese persons resulted in a decreased HC prevalence from 30.8% to 29.3% among men and from 33.6% to 32.5% among women. CONCLUSIONS: Based on these findings, it is suggested that primary prevention programs should advocate having proper BMI for Korean adults with a high-risk of HC. However, whether discouraging consumption of dairy and vegetable oil products can reduce HC prevalence warrants further studies with a prospective longitudinal design.
Abstract
BACKGROUND/OBJECTIVES: A number of studies examined secular trends in blood lipid profiles using time series data of national surveys whereas few studies investigated individual-level factors contributing to such trends. The present study aimed to examine secular trends in dietary and modifiable factors and hyper-LDL-cholesterolemia (HC) prevalence and evaluate their associations using time series data of nationwide surveys. SUBJECTS/METHODS: The study included 41,073 Korean adults aged ≥ 30 years from the 2005, 2007-2009, 2010-2012, 2013-2015, and 2016 Korea National Health and Nutrition Examination Surveys. Stepwise logistic regression analysis was performed to select significant factors associated with HC, which was defined as serum LDL cholesterol levels ≥130 mg/dL. RESULTS: The following factors showed a positive association with HC (P < 0.05): for men having higher body mass index (BMI), being married, having an office job, and consuming higher dairy and vegetable oil products; for women having higher age or BMI, having no job or a non-office job, not in a low-income household, and consuming higher dairy products. In the given model, the 2016 survey data showed that a 2 kg/m2 reduction in BMI of obese persons resulted in a decreased HC prevalence from 30.8% to 29.3% among men and from 33.6% to 32.5% among women. CONCLUSIONS: Based on these findings, it is suggested that primary prevention programs should advocate having proper BMI for Korean adults with a high-risk of HC. However, whether discouraging consumption of dairy and vegetable oil products can reduce HC prevalence warrants further studies with a prospective longitudinal design.
참고문헌 (37)
- Wilson PW, "Established risk factors and coronary artery disease, the Framingham Study", Am J Hypertens, 7, pp.7S~12S (1994)
- Manson JE, "The primary prevention of myocardial infarction", N Engl J Med, 326, pp.1406~1416 (1992)
- Gordon DJ, "High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies", Circulation, 79, pp.8~15 (1989)
- 이승원, "Thirty-Year Trends in Mortality from Cardiovascular Diseases in Korea", Korean Circulation Journal, 45(3), pp.202~209 (2015), 대한심장학회
- Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey (KNHANES VII-1), "Ministry of Health and Welfare", Korea Centers for Disease Control and Prevention, ~ (2017)
- Tran BT, "The prevalence trend of metabolic syndrome and its components and risk factors in Korean adults, results from the Korean National Health and Nutrition Examination Survey 2008-2013", BMC Public Health, 17, pp.71~ (2017)
- Committee for the Korean Guidelines for the Management of Dyslipidemia, "2015 Korean Guidelines for the Management of Dyslipidemia: Executive Summary (English Translation)", Korean Circulation Journal, 46(3), pp.275~306 (2016), 대한심장학회[DOI]
- 윤성하, "Trends in energy intake among Korean adults, 1998-2015: Results from the Korea National Health and Nutrition Examination Survey", Nutrition Research and Practice, 11(2), pp.147~154 (2017), 한국영양학회
- Micha R, "Global, regional, and national consumption levels of dietary fats and oils in 1990 and 2010 : a systematic analysis including 266 countryspecific nutrition surveys", BMJ, 348, pp.g2272~ (2014)
- Research Committee on Serum Lipid Level Survey 1990 in Japan, "Current state of and recent trends in serum lipid levels in the general Japanese population", J Atheroscler Thromb, 2, pp.122~132 (1996)
- Cohen JD, "30-year trends in serum lipids among United States adults : results from the National Health and Nutrition Examination Surveys II, III, and 1999-2006", Am J Cardiol, 106, pp.969~975 (2010)
- Hotchkiss JW, "Trends in cardiovascular disease biomarkers and their socioeconomic patterning among adults in the Scottish population 1995to 2009 : cross-sectional surveys", BMJ Open, 2 (2012)
- Johansson I, "Associations among 25-year trends in diet, cholesterol and BMI from 140, 000 observations in men and women in Northern Sweden", Nutr J, 11, pp.40~ (2012)
- Nam GE, "Trends in lipid profiles among South Korean adults: 2005, 2008 and 2010 Korea National Health and Nutrition Examination Survey", J Public Health(Oxf), 37, pp.286~294 (2015)
- Kotseva K, "Time Trends in Lifestyle, Risk Factor Control, and Use of Evidence-Based Medications in Patients With Coronary Heart Disease in Europe : Results From 3 EUROASPIRE Surveys, 1999-2013", Glob Heart, 12, pp.315~322 (2017)
- Griffey S, "Applying national survey results for strategic planning and program improvement : the National Diabetes Education Program", Eval Program Plann, 48, pp.83~89 (2015)
- Zhou L, "Trends in Lipids and Lipoproteins Among Adults in Northwestern Xinjiang, China, From 1998 Through 2015", J Epidemiol (2018)
- Kweon S, "Data resource profile : the Korea National Health and Nutrition Examination Survey(KNHANES)", Int J Epidemiol, 43, pp.69~77 (2014)
- National Rural Living Science Institute, "Food composition table, 6th ed", ~ (2001)
- Friedewald WT, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge", Clin Chem, 18, pp.499~502 (1972)
- Rashad I, "Associations of cycling with urban sprawl and the gasoline price", Am J Health Promot, 24, pp.27~36 (2009)
- 백인경, "Forecasting obesity prevalence in Korean adults for the years 2020 and 2030 by the analysis of contributing factors", Nutrition Research and Practice, 12(3), pp.251~257 (2018), 한국영양학회
- Finkelstein EA, "Obesity and severe obesity forecasts through 2030", Am J Prev Med, 42, pp.563~570 (2012)
- Carroll MD, "Total and High-density Lipoprotein Cholesterol in Adults : United States, 2015-2016", NCHS Data Brief, 290, pp.1~8 (2017)
- Benatar JR, "Effects of high and low fat dairy food on cardio-metabolic risk factors : a meta-analysis of randomized studies", PLoS One, 8, pp.e76480~ (2013)
- Livingstone KM, "The impact of substituting SFA in dairy products with MUFA or PUFA on CVD risk : evidence from human intervention studies", Nutr Res Rev, 25, pp.193~206 (2012)
- Schwingshackl L, "Effects of oils and solid fats on blood lipids : a systematic review and network meta-analysis", J Lipid Res, 59, pp.1771~1782 (2018)
- Narasimhamurthy K, "Long term feeding effects of heated and fried oils on lipids and lipoproteins in rats", Mol Cell Biochem, 195, pp.143~153 (1999)
- Gadiraju TV, "Fried Food Consumption and Cardiovascular Health : A Review of Current Evidence", Nutrients, 7, pp.8424~8430 (2015)
- Ministry of Health and Welfare, "Dietary Reference Intakes for Koreans 2015", ~ (2015)
- The Korean Nutrition Society, "Dietary Reference Intakes for Koreans 2010", ~ (2010)
- Lamon-Fava S, "Impact of body mass index on coronary heart disease risk factors in men and women. The Framingham Offspring Study", Arterioscler Thromb Vasc Biol, 16, pp.1509~1515 (1996)
- Dattilo AM, "Effects of weight reduction on blood lipids and lipoproteins : a meta-analysis", Am J Clin Nutr, 56, pp.320~328 (1992)
- Sharifi M, "Genetic Architecture of Familial Hypercholesterolaemia", Curr Cardiol Rep, 19, pp.44~ (2017)
- Dochi M, "Shift work is a risk factor for increased total cholesterol level, a 14-year prospective cohort study in 6886 male workers", Occup Environ Med, 66, pp.592~597 (2009)
- Bouillon K, "Decline in low-density lipoprotein cholesterol concentration: lipid-lowering drugs, diet, or physical activity? Evidence from the Whitehall II study", Heart, 97, pp.923~930 (2011)
- Fukuyama N, "Validation of the Friedewald Equation for Evaluation of Plasma LDL-Cholesterol", J Clin Biochem Nutr, 43, pp.1~5 (2008)