Aqueous extract of Laurus nobilis leaf accelerates the alcohol metabolism and prevents liver damage in single-ethanol binge rats
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BACKGROUND/OBJECTIVES: Excessive alcohol consumption has harmful health effects, including alcohol hangovers and alcohol-related liver disease. Therefore, methods to accelerate the alcohol metabolism are needed. Laurus nobilis is a spice, flavoring agent, and traditional herbal medicine against various diseases. This study examined whether the standardized aqueous extract of L. nobilis leaves (LN) accelerates the alcohol metabolism and protects against liver damage in single-ethanol binge Sprague-Dawley (SD) rats. MATERIALS/METHODS: LN was administered orally to SD rats 1 h before ethanol administration (3 g/kg body weight [BW]) at 100 and 300 mg/kg BW. Blood samples were collected 0.5, 1, 2, and 4 h after ethanol administration. The livers were excised 1 h after ethanol administration to determine the hepatic enzyme activity. The alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in the liver tissue were measured. RESULTS: LN decreased the serum ethanol and acetaldehyde levels in ethanol-administered rats. LN increased the hepatic ADH and ALDH activities but decreased the alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities in the ethanol-administered rats. In addition, LN inhibited lipid peroxidation and increased the activities of SOD and GPx. CONCLUSIONS: LN modulates the mediators of various etiological effects of excessive alcohol consumption and enhances the alcohol metabolism and antioxidant activity, making it a potential candidate for hangover treatments.
Abstract
BACKGROUND/OBJECTIVES: Excessive alcohol consumption has harmful health effects, including alcohol hangovers and alcohol-related liver disease. Therefore, methods to accelerate the alcohol metabolism are needed. Laurus nobilis is a spice, flavoring agent, and traditional herbal medicine against various diseases. This study examined whether the standardized aqueous extract of L. nobilis leaves (LN) accelerates the alcohol metabolism and protects against liver damage in single-ethanol binge Sprague-Dawley (SD) rats. MATERIALS/METHODS: LN was administered orally to SD rats 1 h before ethanol administration (3 g/kg body weight [BW]) at 100 and 300 mg/kg BW. Blood samples were collected 0.5, 1, 2, and 4 h after ethanol administration. The livers were excised 1 h after ethanol administration to determine the hepatic enzyme activity. The alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in the liver tissue were measured. RESULTS: LN decreased the serum ethanol and acetaldehyde levels in ethanol-administered rats. LN increased the hepatic ADH and ALDH activities but decreased the alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities in the ethanol-administered rats. In addition, LN inhibited lipid peroxidation and increased the activities of SOD and GPx. CONCLUSIONS: LN modulates the mediators of various etiological effects of excessive alcohol consumption and enhances the alcohol metabolism and antioxidant activity, making it a potential candidate for hangover treatments.
참고문헌 (50)
- Verster JC, "Updating the definition of the alcohol hangover", J Clin Med, 9, pp.823~ (2020)
- Wiese JG, "The alcohol hangover", Ann Intern Med, 132, pp.897~902 (2000)
- Gyamfi MA, "Pathogenesis of alcoholic liver disease: the role of nuclear receptors", Exp Biol Med(Maywood), 235, pp.547~560 (2010)
- Jiang Y, "Alcohol metabolizing enzymes, microsomal ethanol oxidizing system, cytochrome P450 2E1, catalase, and aldehyde dehydrogenase in alcohol-associated liver disease", Biomedicines, 8, pp.50~ (2020)
- Mackus M, "The role of alcohol metabolism in the pathology of alcohol hangover", J Clin Med, 9, pp.3421~ (2020)
- Niemelä O, "Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease", Hepatology, 22, pp.1208~1214 (1995)
- 강경구, "Effects of Raphanus sativus var. niger (Black Radish) Fermented with Lactobacillus plantarum on Alcohol Metabolism in Rats", 건강기능식품미래포럼 학술지, 1(2), pp.1~8 (2021), 건강기능식품미래포럼[DOI]
- Palmer E, "Alcohol Hangover : underlying biochemical, inflammatory and neurochemical mechanisms", Alcohol Alcohol, 54, pp.196~203 (2019)
- Ceni E, "Pathogenesis of alcoholic liver disease : role of oxidative metabolism", World J Gastroenterol, 20, pp.17756~17772 (2014)
- Wang F, "Natural products for the prevention and treatment of hangover and alcohol use disorder", Molecules, 21, pp.64~ (2016)
- Jayawardena R, "Interventions for treatment and", or prevention of alcohol hangover: systematic review, 2017, pp.32, e2600~
- Pittler MH, "Systematic review : hepatotoxic events associated with herbal medicinal products", Aliment Pharmacol Ther, 18, pp.451~471 (2003)
- Irene Joy I. dela Peña, "Supplementation of Laurus nobilis Attenuate Ethanol-induced Psychomotor Alterations in Rats", Natural Product Sciences, 20(1), pp.44~50 (2014), 한국생약학회
- Simić M, "Preliminary assay on the antioxidative activity of Laurus nobilis extracts", Fitoterapia, 74, pp.613~616 (2003)
- Dadalioǧlu I, "Chemical compositions and antibacterial effects of essential oils of Turkish oregano (Origanum minutiflorum), bay laurel (Laurus nobilis), Spanish lavender (Lavandula stoechas L.), and fennel (Foeniculum vulgare) on common foodborne pathogens", J Agric Food Chem, 52, pp.8255~8260 (2004)
- Ferreira A, "The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal", J Ethnopharmacol, 108, pp.31~37 (2006)
- Dhifi W, "Phytochemical composition and antioxidant activity of Tunisian Laurus nobilis", Pak J Pharm Sci, 31, pp.2397~2402 (2018)
- Lee EH, "Laurus nobilis leaf extract controls inflammation by suppressing NLRP3 inflammasome activation", J Cell Physiol, 234, pp.6854~6864 (2019)
- Bouadid I, "Study of the anti-hypertensive effect of Laurus nobilis in rats", Cardiovasc Hematol Agents Med Chem, 21, pp.42~54 (2023)
- Mohammed RR, "Biomedical effects of Laurus nobilis L. leaf extract on vital organs in streptozotocin-induced diabetic rats: Experimental research", Ann Med Surg(Lond), 61, pp.188~197 (2020)
- Esam Y. Qnais, "Antidiarrheal Activity of Laurus nobilis L. Leaf Extract in Rats", Journal of Medicinal Food, 15(1), pp.51~57 (2012), 한국식품영양과학회
- Marza Hamza N, "Biological effects of aqueous extract of Laurus noboilis L. leaves on some histological and immunological parameters in male rat liver affected by aluminum chloride", Arch Razi Inst, 76, pp.1745~1753 (2021)
- Matsuda H, "Inhibitory mechanism of costunolide, a sesquiterpene lactone isolated from Laurus nobilis, on blood-ethanol elevation in rats : involvement of inhibition of gastric emptying and increase in gastric juice secretion", Alcohol Alcohol, 37, pp.121~127 (2002)
- Dobroslavić E, "Isolation of Laurus nobilis leaf polyphenols : a review on current techniques and future perspectives", Foods, 11, pp.235~ (2022)
- Paparella A, "A review of the botany, volatile composition, biochemical and molecular aspects, and traditional uses of Laurus nobilis", Plants, 11, pp.1209~ (2022)
- Yoshikawa M, "Alcohol absorption inhibitors from bay leaf(Laurus nobilis) : structure-requirements of sesquiterpenes for the activity", Bioorg Med Chem, 8, pp.2071~2077 (2000)
- Tinoco MT, "Effects of a hexane extract from Laurus novocanariensis leaves on the ethanol metabolism of Wistar rats", Fitoterapia, 80, pp.130~133 (2009)
- Medeiros-Fonseca B, "Laurus nobilis(laurel)aqueous leaf extract’s toxicological and anti-tumor activities in HPV16-transgenic mice", Food Funct, 9, pp.4419~4428 (2018)
- Vidal F, "Influence of chronic alcohol abuse and liver disease on hepatic aldehyde dehydrogenase activity", Alcohol, 15, pp.3~8 (1998)
- Mackus M, "The association between ethanol elimination rate and hangover severity", Int J Environ Res Public Health, 17, pp.4324~ (2020)
- Contreras-Zentella ML, "Ethanol metabolism in the liver, the induction of oxidant stress, and the antioxidant defense system", Antioxidants(Basel), 11, pp.1258~ (2022)
- Yang Z, "The mitigative effect of lotus root(Nelumbo nucifera Gaertn)extract on acute alcoholism through activation of alcohol catabolic enzyme, reduction of oxidative stress, and protection of liver function", Front Nutr, 9, pp.1111283~ (2023)
- Kang HW, "Isolation and characterization of alkyl peroxy radical scavenging compound from leaves of Laurus nobilis", Biol Pharm Bull, 25, pp.102~108 (2002)
- Lee HY, "Turmeric extract (Curcuma longa L.) regulates hepatic toxicity in a single ethanol binge rat model", Heliyon, 8, pp.e10737~ (2022)
- Lee S, "Relative protective activities of quercetin, quercetin-3-glucoside, and rutin in alcohol-induced liver injury", J Food Biochem, 43, pp.e13002~ (2019)
- 이희정, "In vivo protective effect against ethanol metabolism and liver injury of oyster (Crassostrea Gigas) extracts obtained via subcritical water processing", Food Science and Biotechnology, 30(8), pp.1063~1074 (2021), 한국식품과학회[DOI]
- Kitakaze T, "Aged garlic extract prevents alcohol-induced cytotoxicity through induction of aldehyde dehydrogenase 2 in the liver of mice", Mol Nutr Food Res, 67, pp.e2200627~ (2023)
- Wu D, "Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-κB DNA binding activity", Mol Pharmacol, 66, pp.749~760 (2004)
- Ali H, "Lipid peroxidation derived reactive aldehydes in alcoholic liver disease", Curr Opin Toxicol, 13, pp.110~117 (2019)
- Cederbaum AI, "Role of oxidative stress in alcohol-induced liver injury", Arch Toxicol, 83, pp.519~548 (2009)
- Ezhilarasan D, "Oxidative stress is bane in chronic liver diseases : clinical and experimental perspective", Arab J Gastroenterol, 19, pp.56~64 (2018)
- De Minicis S, "Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex", J Gastroenterol Hepatol, 23(Suppl 1), pp.S98~S103 (2008)
- Cederbaum AI, "Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells", J Gastroenterol Hepatol, 21(Suppl 3), pp.S22~S25 (2006)
- Wang F, "Effects of beverages on alcohol metabolism : Potential health benefits and harmful impacts", Int J Mol Sci, 17, pp.354~ (2016)
- 이정윤, "In Vitro 및 In Vivo 알코올 유도 간 손상에 대한 신선초 추출물의 효과", 한국식품영양과학회지, 45(10), pp.1391~1397 (2016), 한국식품영양과학회
- Li BY, "Effects of different green tea extracts on chronic alcohol induced-fatty liver disease by ameliorating oxidative stress and inflammation in mice", Oxid Med Cell Longev, 2021, pp.5188205~ (2021)
- Li HY, "Plant-based foods and their bioactive compounds on fatty liver disease : effects, mechanisms, and clinical application", Oxid Med Cell Longev, 2021, pp.6621644~ (2021)
- Li S, "Effects of herbal infusions, tea and carbonated beverages on alcohol dehydrogenase and aldehyde dehydrogenase activity", Food Funct, 5, pp.42~49 (2014)
- Manir MM, "Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase", Bioorg Med Chem, 20, pp.2376~2381 (2012)
- Yamashita H, "Ecklonia cava polyphenol has a protective effect against ethanol-induced liver injury in a cyclic AMP-dependent manner", Mar Drugs, 13, pp.3877~3891 (2015)
