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Resveratrol promotes mitochondrial energy metabolism in exercise-induced fatigued rats

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BACKGROUND/OBJECTIVES: To investigate the effect and regulator y mechanism of resveratrol supplementation on the mitochondrial energy metabolism of rats with exercise- induced fatigue. MATERIALS/METHODS: Forty-eight Sprague-Dawley male rats were divided randomly into a blank control group (C), resveratrol group (R), exercise group (E), and exercise and resveratrol group (ER), with 12 rats in each group. Group ER and group E performed 6-wk swimming training with 5% wt-bearing, 60 min each time, 6 days a wk. Group ER was given resveratrol 50 mg/kg by gavage one hour after exercise; group R was only given resveratrol 50 mg/kg by gavage; group C and group E were fed normally. The same volume of solvent was given by gavage ever y day. RESULTS: Resveratrol supplementation could reduce the plasma blood urea nitrogen content, creatine kinase activity, and malondialdehyde content in the skeletal muscle, increase the total superoxide dismutase activity in the skeletal muscle, and improve the fatigue state. Resveratrol supplementation could improve the activities of Ca2+-Mg2+-ATPase, Na+-K+- ATPase, succinate dehydrogenase, and citrate synthase in the skeletal muscle. Furthermore, resveratrol supplementation could up-regulate the sirtuin 1 (SIRT1)-proliferator-activated receptor gamma coactivator-1α ( P G C -1 α)-nuclear respirator y factor 1 pathway. CONCLUSIONS: Resveratrol supplementation could promote mitochondrial biosynthesis via the SIRT1/PGC-1α pathway, increase the activity of the mitochondrial energy metabolism- related enzymes, improve the antioxidant capacity of the body, and promote recover y from exercise-induced fatigue.

Abstract

BACKGROUND/OBJECTIVES: To investigate the effect and regulator y mechanism of resveratrol supplementation on the mitochondrial energy metabolism of rats with exercise- induced fatigue. MATERIALS/METHODS: Forty-eight Sprague-Dawley male rats were divided randomly into a blank control group (C), resveratrol group (R), exercise group (E), and exercise and resveratrol group (ER), with 12 rats in each group. Group ER and group E performed 6-wk swimming training with 5% wt-bearing, 60 min each time, 6 days a wk. Group ER was given resveratrol 50 mg/kg by gavage one hour after exercise; group R was only given resveratrol 50 mg/kg by gavage; group C and group E were fed normally. The same volume of solvent was given by gavage ever y day. RESULTS: Resveratrol supplementation could reduce the plasma blood urea nitrogen content, creatine kinase activity, and malondialdehyde content in the skeletal muscle, increase the total superoxide dismutase activity in the skeletal muscle, and improve the fatigue state. Resveratrol supplementation could improve the activities of Ca2+-Mg2+-ATPase, Na+-K+- ATPase, succinate dehydrogenase, and citrate synthase in the skeletal muscle. Furthermore, resveratrol supplementation could up-regulate the sirtuin 1 (SIRT1)-proliferator-activated receptor gamma coactivator-1α ( P G C -1 α)-nuclear respirator y factor 1 pathway. CONCLUSIONS: Resveratrol supplementation could promote mitochondrial biosynthesis via the SIRT1/PGC-1α pathway, increase the activity of the mitochondrial energy metabolism- related enzymes, improve the antioxidant capacity of the body, and promote recover y from exercise-induced fatigue.

참고문헌 (32)

  1. Li M, "The mechanism and prevention of mitochondrial injury after exercise", J Physiol Biochem, 77, pp.215~225 (2021)
  2. Ismaeel A, "Resistance training, antioxidant status, and antioxidant supplementation", Int J Sport Nutr Exerc Metab, 29, pp.539~547 (2019)
  3. Corr LD, "The effects of cocoa flavanols on indices of muscle recovery and exercise performance : a narrative review", BMC Sports Sci Med Rehabil, 13, pp.90~ (2021)
  4. Solheim SA, "Use of nutritional supplements by Danish elite athletes and fitness customers", Scand J Med Sci Sports, 27, pp.801~808 (2017)
  5. Galiniak S, "Health benefits of resveratrol administration", Acta Biochim Pol, 66, pp.13~21 (2019)
  6. Hou CY, "The effects of resveratrol in the treatment of metabolic syndrome", Int J Mol Sci, 20, pp.535~ (2019)
  7. Ma N, "Antifatigue effect of functional cookies fortified with mushroom powder(Tricholoma matsutake)in mice", J Food Sci, 85, pp.4389~4395 (2020)
  8. Fernandes T, "Aerobic exercise training-induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin(1-7)", Hypertension, 58, pp.182~189 (2011)
  9. Alway SE, "Resveratrol enhances exercise-induced cellular and functional adaptations of skeletal muscle in older men and women", J Gerontol A Biol Sci Med Sci, 72, pp.1595~1606 (2017)
  10. Polley KR, "Influence of exercise training with resveratrol supplementation on skeletal muscle mitochondrial capacity", Appl Physiol Nutr Metab, 41, pp.26~32 (2016)
  11. Gocmez SS, "Protective effects of resveratrol on aginginduced cognitive impairment in rats", Neurobiol Learn Mem, 131, pp.131~136 (2016)
  12. Wang X, "Antifatigue potential activity of Sarcodon imbricatus in acute excise-treated and chronic fatigue syndrome in mice via regulation of Nrf2-mediated oxidative stress", Oxid Med Cell Longev, 2018, pp.9140896~ (2018)
  13. Wang L, "The decapeptide CMS001 enhances swimming endurance in mice", Peptides, 29, pp.1176~1182 (2008)
  14. Osman WN, "Standardized Morinda citrifolia L. and Morinda elliptica L. leaf extracts alleviated fatigue by improving glycogen storage and lipid", carbohydrate metabolism, 2018, pp.32, 2078~2085
  15. Zhang G, "Modulated expression and enzymatic activities of Darkbarbel catfish, Pelteobagrus vachelli for oxidative stress induced by acute hypoxia and reoxygenation", Chemosphere, 151, pp.271~279 (2016)
  16. Pirkmajer S, "The role of AMPK in regulation of Na+, K+-ATPase in skeletal muscle : does the gauge always plug the sink?", J Muscle Res Cell Motil, 42, pp.77~97 (2021)
  17. Wyckelsma VL, "Inactivity and exercise training differentially regulate abundance of Na+-K+-ATPase in human skeletal muscle", J Appl Physiol, 127, pp.905~920 (2019)
  18. Fernández ÁF, "Interaction between the autophagy protein Beclin 1 and Na+, K+-ATPase during starvation, exercise, and ischemia", JCI Insight, 5, pp.e133282~ (2020)
  19. Rasheed MR, "Succinate dehydrogenase complex : an updated review", Arch Pathol Lab Med, 142, pp.1564~1570 (2018)
  20. Jacques M, "Mitochondrial respiration variability and simulations in human skeletal muscle : the Gene SMART study", FASEB J, 34, pp.2978~2986 (2020)
  21. Alhindi Y, "Low citrate synthase activity is associated with glucose intolerance and lipotoxicity", J Nutr Metab, 2019, pp.8594825~ (2019)
  22. Reid SN, "In vitro and in vivo effects of fermented oyster-derived lactate on exercise endurance indicators in mice", Int J Environ Res Public Health, 17, pp.8811~ (2020)
  23. Jingyu Sun, "Early potential effects of resveratrol supplementation on skeletal muscle adaptation involved in exercise-induced weight loss in obese mice", BMB Reports, 51(4), pp.200~205 (2018), 생화학분자생물학회
  24. Vincenzi KL, "Effects of resveratrol on alterations in cerebrum energy metabolism caused by metabolites accumulated in type I citrullinemia in rats", Naunyn Schmiedebergs Arch Pharmacol, 394, pp.873~884 (2021)
  25. Villareal MO, "L-citrulline supplementation-increased skeletal muscle PGC-1αexpression is associated with exercise performance and increased skeletal muscle weight", Mol Nutr Food Res, 62, pp.e1701043~ (2018)
  26. Vargas-Ortiz K, "Exercise and sirtuins : a way to mitochondrial health in skeletal muscle", Int J Mol Sci, 20, pp.2717~ (2019)
  27. Ma S, "SIRT1 activation by resveratrol alleviates cardiac dysfunction via mitochondrial regulation in diabetic cardiomyopathy mice", Oxid Med Cell Longev, 2017, pp.4602715~ (2017)
  28. Huang WC, "Association of physical performance and biochemical profile of mice with intrinsic endurance swimming", Int J Med Sci, 13, pp.892~901 (2016)
  29. Menzies KJ, "Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis", J Biol Chem, 288, pp.6968~6979 (2013)
  30. Chuang YC, "Resveratrol promotes mitochondrial biogenesis and protects against seizure-induced neuronal cell damage in the hippocampus following status epilepticus by activation of the PGC-1α signaling pathway", Int J Mol Sci, 20, pp.1422~1476 (2019)
  31. Wang D, "Resveratrol improves muscle atrophy by modulating mitochondrial quality control in STZ-induced diabetic mice", Mol Nutr Food Res, 62, pp.e1700941~ (2018)
  32. Muhammad MH, "Resveratrol and", or exercise training counteract aging-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function, 2018, pp.68, 681~688

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