본문 바로가기
KERD
논문KCI 등재

Myocardial Positron Emission Tomography for Evaluation of Cardiac Sarcoidosis: Specialized Protocols for Better Diagnosis

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류내과학

초록

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology with various clinical presentations depending on the organs involved. Since cardiac sarcoidosis (CS) portends a higher risk of morbidity and mortality, early diagnosis and aggressive medical treatment are essential to improve the prognosis. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) has emerged as an important tool with practical advantages in assessing disease activity and monitoring the treatment response in patients with CS. While it has high sensitivity, it also has great variability in specificity, probably due to normal physiologic myocardial FDG uptake, which interferes with the evaluation and follow-up of CS using FDG-PET. This review details the technical aspects of FDG-PET imaging for evaluating and diagnosing CS, assessing disease activity, and monitoring therapeutic response.

Abstract

Sarcoidosis is a multisystemic granulomatous disease of unknown etiology with various clinical presentations depending on the organs involved. Since cardiac sarcoidosis (CS) portends a higher risk of morbidity and mortality, early diagnosis and aggressive medical treatment are essential to improve the prognosis. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) has emerged as an important tool with practical advantages in assessing disease activity and monitoring the treatment response in patients with CS. While it has high sensitivity, it also has great variability in specificity, probably due to normal physiologic myocardial FDG uptake, which interferes with the evaluation and follow-up of CS using FDG-PET. This review details the technical aspects of FDG-PET imaging for evaluating and diagnosing CS, assessing disease activity, and monitoring therapeutic response.

참고문헌 (56)

  1. Porter GH, "Sarcoid heart disease", N Engl J Med, 263, pp.1350~1357 (1960)
  2. Birnie DH, "Cardiac Sarcoidosis", J Am Coll Cardiol, 68, pp.411~421 (2016)
  3. Silverman KJ, "Cardiac sarcoid : a clinicopathologic study of 84 unselected patients with systemic sarcoidosis", Circulation, 58, pp.1204~1211 (1978)
  4. Bennett MK, "Evaluation of the role of endomyocardial biopsy in 851 patients with unexplained heart failure from 2000-2009", Circ Heart Fail, 6, pp.676~684 (2013)
  5. Birnie DH, "HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis", Heart Rhythm, 11, pp.1305~1323 (2014)
  6. JCS Joint Working Group, "Guidelines for diagnosis and treatment of myocarditis(JCS 2009) : digest version", Circ J, 75, pp.734~743 (2011)
  7. Aggarwal NR, "Advances in imaging for diagnosis and management of cardiac sarcoidosis", Eur Heart J Cardiovasc Imaging, 16, pp.949~958 (2015)
  8. Blankstein R, "Evaluation of known or suspected cardiac sarcoidosis", Circ Cardiovasc Imaging, 9, pp.e000867~ (2016)
  9. Ohira H, "Clinical application of 18F-fluorodeoxyglucose PET and LGE CMR in cardiac sarcoidosis", Ann Nucl Cardiol, 3, pp.125~130 (2017)
  10. Okumura W, "Usefulness of fasting 18F-FDG PET in identification of cardiac sarcoidosis", J Nucl Med, 45, pp.1989~1998 (2004)
  11. Nishiyama Y, "Comparative evaluation of 18F-FDG PET and 67Ga scintigraphy in patients with sarcoidosis", J Nucl Med, 47, pp.1571~1576 (2006)
  12. Ishida Y, "Recommendations for(18)F-fluorodeoxyglucose positron emission tomography imaging for cardiac sarcoidosis : Japanese Society of Nuclear Cardiology recommendations", Ann Nucl Med, 28, pp.393~403 (2014)
  13. Wisneski JA, "Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans", J Clin Invest, 79, pp.359~366 (1987)
  14. Santalucía T, "Developmental regulation of GLUT-1 (erythroid", Hep G2) and GLUT-4 (muscle, Endocrinology, pp.1992, 130[DOI]
  15. Montessuit C, "Regulation and dysregulation of glucose transport in cardiomyocytes", Biochim Biophys Acta, 1833, pp.848~856 (2013)
  16. Randle PJ, "The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus", Lancet, 1, pp.785~789 (1963)
  17. Nuutila P, "Glucose-free fatty acid cycle operates in human heart and skeletal muscle in vivo", J Clin Invest, 89, pp.1767~1774 (1992)
  18. Kubota K, "Re-evaluation of myocardial FDG uptake in hyperglycemia", J Nucl Med, 37, pp.1713~1717 (1996)
  19. Yamada K, "Experimental studies on myocardial glucose metabolism of rats with 18F-2-fluoro-2-deoxy-D-glucose", Eur J Nucl Med, 10, pp.341~345 (1985)
  20. Miyagawa M, "Positron emission tomography-computed tomography for imaging of inflammatory cardiovascular diseases", Circ J, 78, pp.1302~1310 (2014)
  21. Wieman HL, "Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase", Akt regulation of Glut1 activity and trafficking, 2007, pp.18, 1437~1446
  22. Kominsky DJ, "Metabolic shifts in immunity and inflammation", J Immunol, 184, pp.4062~4068 (2010)
  23. Maratou E, "Glucose transporter expression on the plasma membrane of resting and activated white blood cells", Eur J Clin Invest, 37, pp.282~290 (2007)
  24. Simpson IA, "The facilitative glucose transporter GLUT3 : 20 years of distinction", Am J Physiol Endocrinol Metab, 295, pp.E242~E253 (2008)
  25. Youssef G, "The use of 18F-FDG PET in the diagnosis of cardiac sarcoidosis : a systematic review and metaanalysis including the Ontario experience", J Nucl Med, 53, pp.241~248 (2012)
  26. Yokoyama R, "Quantitative analysis of myocardial 18F-fluorodeoxyglucose uptake by PET", CT for detection of cardiac sarcoidosis, 2015, pp.195, 180~187
  27. Tahara N, "Heterogeneous myocardial FDG uptake and the disease activity in cardiac sarcoidosis", JACC Cardiovasc Imaging, 3, pp.1219~1228 (2010)
  28. Sperry BW, "Prognostic impact of extent, severity, and heterogeneity of abnormalities on (18)F-FDG PET scans for suspected cardiac sarcoidosis", JACC Cardiovasc Imaging, 11, pp.336~345 (2018)
  29. Ahmadian A, "Quantitative interpretation of FDG PET", CT with myocardial perfusion imaging increases diagnostic information in the evaluation of cardiac sarcoidosis, 2014, pp.21, 925~939
  30. Blankstein R, "Maximizing the prognostic value of cardiac PET in patients with suspected cardiac sarcoidosis : a simple semiquantitative score may help", JACC Cardiovasc Imaging, 11, pp.346~348 (2018)
  31. Boellaard R, "FDG PET", CT: EANM procedure guidelines for tumour imaging: version 2.0, 2015, pp.42, 328~354
  32. Lindholm P, "Influence of the blood glucose concentration on FDG uptake in cancer--a PET study", J Nucl Med, 34, pp.1~6 (1993)
  33. Chareonthaitawee P, "Joint SNMMI-ASNC expert consensus document on the role of(18)F-FDG PET", CT in cardiac sarcoid detection and therapy monitoring, 2017, pp.58, 1341~1353
  34. Morooka M, "Long fasting is effective in inhibiting physiological myocardial 18F-FDG uptake and for evaluating active lesions of cardiac sarcoidosis", EJNMMI Res, 4, pp.1~ (2014)
  35. Ishimaru S, "Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis", Eur Heart J, 26, pp.1538~1543 (2005)
  36. Ohira H, "Myocardial imaging with 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in sarcoidosis", Eur J Nucl Med Mol Imaging, 35, pp.933~941 (2008)
  37. Langah R, "Effectiveness of prolonged fasting 18f-FDG PET-CT in the detection of cardiac sarcoidosis", J Nucl Cardiol, 16, pp.801~810 (2009)
  38. Persson E, "Plasma lipolytic activity after subcutaneous administration of heparin and a low molecular weight heparin fragment", Thromb Res, 46, pp.697~704 (1987)
  39. Persson E, "Lipoprotein lipase, hepatic lipase and plasma lipolytic activity. Effects of heparin and a low molecular weight heparin fragment (Fragmin)", Acta Med Scand Suppl, 724, pp.1~56 (1988)
  40. fluoro-D-glucose uptake artifacts in positron emission tomography using dietary carbohydrate restriction, "Mol Imaging Biol", 2002, 232~237
  41. Cheng VY, "Impact of carbohydrate restriction with and without fatty acid loading on myocardial 18F-FDG uptake during PET : A randomized controlled trial", J Nucl Cardiol, 17, pp.286~291 (2010)
  42. Ohira H, "¹⁸F-Fluoro-2-deoxyglucose positron emission tomography in cardiac sarcoidosis", Eur J Nucl Med Mol Imaging, 38, pp.1773~1783 (2011)
  43. Wykrzykowska J, "Imaging of inflamed and vulnerable plaque in coronary arteries with 18F-FDG PET", CT in patients with suppression of myocardial uptake using a low-carbohydrate, high-fat preparation, 2009, pp.50, 563~568
  44. Williams G, "Suppression of myocardial 18F-FDG uptake by preparing patients with a high-fat, low-carbohydrate diet", AJR Am J Roentgenol, 190, pp.W151~W156 (2008)
  45. Harisankar CN, "Utility of high fat and low carbohydrate diet in suppressing myocardial FDG uptake", J Nucl Cardiol, 18, pp.926~936 (2011)
  46. Demeure F, "A randomized trial on the optimization of 18F-FDG myocardial uptake suppression : implications for vulnerable coronary plaque imaging", J Nucl Med, 55, pp.1629~1635 (2014)
  47. Dilsizian V, "ASNC imaging guidelines", SNMMI procedure standard for positron emission tomography(PET)nuclear cardiology procedures, 2016, pp.23, 1187~1226
  48. Hamzeh N, "Pathophysiology and clinical management of cardiac sarcoidosis", Nat Rev Cardiol, 12, pp.278~288 (2015)
  49. Blankstein R, "Cardiac positron emission tomography enhances prognostic assessments of patients with suspected cardiac sarcoidosis", J Am Coll Cardiol, 63, pp.329~336 (2014)
  50. Yamagishi H, "Identification of cardiac sarcoidosis with(13)N-NH(3)", (18)F-FDG PET, 2003, pp.44, 1030~1036
  51. Tadamura E, "Images in cardiovascular medicine. Multimodality imaging of cardiac sarcoidosis before and after steroid therapy", Circulation, 113, pp.e771~e773 (2006)
  52. Ahmadian A, "The response of FDG uptake to immunosuppressive treatment on FDG PET", CT imaging for cardiac sarcoidosis, 2017, pp.24, 413~424
  53. Lee PI, "The role of serial FDG PET for assessing therapeutic response in patients with cardiac sarcoidosis", J Nucl Cardiol, 24, pp.19~28 (2017)
  54. Osborne MT, "Reduction in ¹⁸F-fluorodeoxyglucose uptake on serial cardiac positron emission tomography is associated with improved left ventricular ejection fraction in patients with cardiac sarcoidosis", J Nucl Cardiol, 21, pp.166~174 (2014)
  55. Shelke AB, "Serial FDG-PET scans help to identify steroid resistance in cardiac sarcoidosis", Int J Cardiol, 228, pp.717~722 (2017)
  56. Dweck MR, "Hybrid magnetic resonance imaging and positron emission tomography with fluorodeoxyglucose to diagnose active cardiac sarcoidosis", JACC Cardiovasc Imaging, 11, pp.94~107 (2018)

관련 논문AI추천

이 간행물의 다른 논문 (12건)