야생종 담배 추출물(Nicotiana debneyi)의 멜라닌생성 억제효과
Inhibitory Effect of Nicotiana debneyi against the Melanogenesis
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초록
본 연구에서는 N. debneyi 지상부 50% 에탄올 추출물(ND50E)의 미백화장품 소재로의 활용가능성을 파악하기 위해 N. debneyi 지상부 50% 에탄올 추출물(ND50E)의 melanin 생성억제활성을 평가하였다. N. debneyi 지상부 50% 에탄올 추출물(ND50E)은 tyrosinase의 단백질 수준을 감소시켜 extracellular melanin과 intracellar melanin의 생성을 억제하는것으로 판단된다. N. debneyi 지상부 50% 에탄올 추출물(ND50E)은 효과적인 멜라닌 생성 억제제로서 미백화장품 소재로의 활용 가능성이 높음을 제안한다.
Abstract
This study aimed to evaluate the potential use of 50% ethanol extract from the aerial parts of N. debneyi (ND50E) as a whitening cosmetic ingredient by assessing its inhibitory activity on melanin production. The results demonstrated that ND50E significantly suppressed both extracellular and intracellular melanin production. Additionally, ND50E had no effect on the expression of tyrosinase mRNA, but it significantly reduced the protein level of tyrosinase. These findings suggest that ND50E inhibits melanin production by decreasing the protein level of tyrosinase. Therefore, ND50E holds significant potential as an effective melanin production inhibitor for use in whitening cosmetic formulations.
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