일 종합병원 정신건강의학과 외래환자에서 벤조디아제핀 사용
Prescription Patterns of Benzodiazepine for Outpatients in a Psychiatric Department in Korea
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective : This study examined benzodiazepine prescription patterns of outpatients visiting the psychiatry department in a single general hospital in Korea Methods : A retrospective descriptive analysis of benzodiazepine prescriptions was performed on a database from 2014 in a general hospital in Korea. We analyzed the following factors of adult outpatients: demographic factors such as sex and age, amount of benzodiazepine prescribed, treatment duration, and diagnosis based on the ICD-10. Results : In 2014, benzodiazepines were prescribed to 46.4% of the outpatients. Percentage of benzodiazepine prescription increased with age and was highest in the age group 40-59 years. Prescription was more prevalent in women and the prescription percentage increased by treatment duration. Patients with the F4 diagnosis (neurotic, stress-related and somatoform disorders) were the most highly prescribed group. For all diagnosis groups, prescription was more prevalent in females or similar for both sexes except for patients with F5 diagnosis (behavioral syndromes associated with physiological disturbances and physical factors), with males being more predominant. Conclusion : Despite the concern regarding the rate of benzodiazepine prescription and administration to geriatric patients, long-term prescription and usage among older patients is still prevalent. (Anxiety and Mood 2015;11(2):143-148)
Abstract
Objective : This study examined benzodiazepine prescription patterns of outpatients visiting the psychiatry department in a single general hospital in Korea Methods : A retrospective descriptive analysis of benzodiazepine prescriptions was performed on a database from 2014 in a general hospital in Korea. We analyzed the following factors of adult outpatients: demographic factors such as sex and age, amount of benzodiazepine prescribed, treatment duration, and diagnosis based on the ICD-10. Results : In 2014, benzodiazepines were prescribed to 46.4% of the outpatients. Percentage of benzodiazepine prescription increased with age and was highest in the age group 40-59 years. Prescription was more prevalent in women and the prescription percentage increased by treatment duration. Patients with the F4 diagnosis (neurotic, stress-related and somatoform disorders) were the most highly prescribed group. For all diagnosis groups, prescription was more prevalent in females or similar for both sexes except for patients with F5 diagnosis (behavioral syndromes associated with physiological disturbances and physical factors), with males being more predominant. Conclusion : Despite the concern regarding the rate of benzodiazepine prescription and administration to geriatric patients, long-term prescription and usage among older patients is still prevalent. (Anxiety and Mood 2015;11(2):143-148)
참고문헌 (27)
- Sonnenberg CM, "Ten-year trends in benzodiazepine use in the Dutch population", Soc Psychiatry Psychiatr Epidemiol, 47, pp.293~301 (2012)
- Luijendijk HJ, "Determinants of chronic benzodiazepine use in the elderly : a longitudinal study", Br J Clin Pharmacol, 65, pp.593~599 (2008)
- McLeod PJ, "Defining inappropriate practices in prescribing for elderly people : a national consensus panel", CMAJ, 156, pp.385~391 (1997)
- Gray SL, "Benzodiazepine use and physical disability in community-dwelling older adults", J Am Geriatr Soc, 54, pp.224~230 (2006)
- Madhusoodanan S, "Safety of benzodiazepines in the geriatric population", Expert Opin Drug Saf, 3, pp.485~493 (2004)
- Cook JM, "Patient perspectives on long-term anxiolytic benzodiazepine use and discontinuation : a qualitative study", J Gen Intern Med, 22, pp.1094~1100 (2007)
- Hogan DB, "Prevalence and potential consequences of benzodiazepine use in senior citizens: results from the Canadian Study of Health and Aging", Can J Clin Pharmacol, 10, pp.72~77 (2003)
- Cunningham CM, "Patternsin the use of benzodiazepines in British Columbia : examining the impact of increasing research andguideline cautions against long-term use", Health Policy, 97, pp.122~129 (2010)
- Olfson M, "Benzodiazepine use in the United States", JAMA Psychiatry, 72, pp.136~142 (2015)
- National Evidence-based Healthcare Collaborating Agency, "Prescription pattern and safety of benzodiazepines", ~ (2012)
- The ICD-10 Classification of Mental and Behavioural Disorders, Clinical Descriptions and Diagnostic Guidelines. an edition in Korean, "World Health Organization", Il Cho Kak, ~ (1992)
- Hogan DB, "Canadian Study of Health and Aging. Prevalenceand potential consequences of benzodiazepine usein senior citizens: results from the Canadian Studyof Health and Aging", Can J Clin Pharmacol, 10, pp.72~77 (2003)
- Petitjean S, "Benzodiazepine prescribing to the Swiss adult population : results from a national survey of community pharmacies", Int Clin Psychopharmacol, 22, pp.292~298 (2007)
- Simon GE, "Outcome of new benzodiazepine prescriptions to older adults in primary care", Gen Hosp Psychiatry, 28, pp.374~378 (2006)
- Manthey L, "Determinants of initiated and continued benzodiazepine use in the Netherlands study of depression and anxiety", J Clin Psychopharmacol, 31, pp.774~779 (2011)
- Ancoli-Israel S, "Sleep and its disorders in aging populations", Sleep Med, 10, pp.S7~S11 (2009)
- Wolitzky-Taylor KB, "Anxiety disorders in older adults : a comprehensive review", Depress Anxiety, 27, pp.190~211 (2010)
- Manthey L, "Determinants of initiated and continued benzodiazepine use in the Netherlands study of depression and anxiety", J Clin Psychopharmacol, 31, pp.774~779 (2011)
- Lagnaoui R, "Patterns and correlates of benzodiazepine use in the Frenchgeneral population", Eur J Clin Pharmacol, 60, pp.523~529 (2004)
- van Hulten R, "Initial 3-month usage characteristics predict longterm use of benzodiazepines : an 8-year follow-up", Eur J Clin Pharmacol, 58, pp.689~694 (2003)
- Van der Heyden JHA, "Gender differences in the use of anxiolytics and antidepressants : a population based study", Pharmacoepidemiol Drug Saf, 18, pp.1101~1110 (2009)
- Mendelson WB, "Clinical distinctions between long-acting and short-acting benzodiazepines", J Clin Psychiatry, 53, pp.4~7 (1992)
- Finkle WD, "Risk of fractures requiring hospitalization after an initial prescription for zolpidem, alprazolam, lorazepam, or diazepam in older adults", J Am Geriatr Soc, 59, pp.1883~1890 (2011)
- Lai MM, "Long-term use of zolpidem increases the risk of major injury : a population-based cohort study", Mayo Clin Proc, 89, pp.589~594 (2014)
- Cook JM, "Older patient perspectives on long-term anxiolytic benzodiazepine use and discontinuation : a qualitative study", J Gen Intern Med, 22, pp.1094~1100 (2007)
- Gould RL, "Interventions for reducing benzodiazepine use in older people : meta-analysis of randomised controlled trials", Br J Psychiatry, 204, pp.98~107 (2014)
- Mugunthan K, "Minimal interventions to decrease long-term use of benzodiazepines in primary care: a systematic review and meta-analysis", Br J Gen Pract, 61, pp.e573~e578 (2011)