공황장애 환자에서의 작업기억 장애
Impairment of Working Memory in Patients with Panic Disorder
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective : The purpose of this study was to investigate the impairment of working memory in patients with panic disorder through neuropsychological examination. Methods : A total of 38 patients who met the DSM-5 criteria for panic disorder and 40 healthy controls were recruited in this study. Controls and patients were matched for age, sex, and education. The Hamilton Anxiety Rating Scale (HAMA), the Hamilton Depression Rating Scale (HAMD), and the Panic Disorder Severity Scale (PDSS) were used to evaluate the severities of anxiety, depression, and panic disorder. Further, the digit span task was performed to assess working memory. In addition, a sub-analysis was performed after excluding participants with clinical depressive symptoms. Finally, a sub-analysis by the education level was performed. Results : The HAMA, HAMD, and PDSS scores were significantly higher for patients with panic disorder compared to controls. The scores of digit span forward, digit span backward, digit span sequencing, and total digit span were significantly lower for patients with panic disorder compared to controls. In the sub-analyses excluding patients with depression and by education level, the score of total digit span was significantly lower for patients with panic disorder compared to controls. Conclusion : In this study, patients with panic disorder had deficits in working memory compared to healthy controls. (Anxiety and Mood 2021;17(1):41-47)
Abstract
Objective : The purpose of this study was to investigate the impairment of working memory in patients with panic disorder through neuropsychological examination. Methods : A total of 38 patients who met the DSM-5 criteria for panic disorder and 40 healthy controls were recruited in this study. Controls and patients were matched for age, sex, and education. The Hamilton Anxiety Rating Scale (HAMA), the Hamilton Depression Rating Scale (HAMD), and the Panic Disorder Severity Scale (PDSS) were used to evaluate the severities of anxiety, depression, and panic disorder. Further, the digit span task was performed to assess working memory. In addition, a sub-analysis was performed after excluding participants with clinical depressive symptoms. Finally, a sub-analysis by the education level was performed. Results : The HAMA, HAMD, and PDSS scores were significantly higher for patients with panic disorder compared to controls. The scores of digit span forward, digit span backward, digit span sequencing, and total digit span were significantly lower for patients with panic disorder compared to controls. In the sub-analyses excluding patients with depression and by education level, the score of total digit span was significantly lower for patients with panic disorder compared to controls. Conclusion : In this study, patients with panic disorder had deficits in working memory compared to healthy controls. (Anxiety and Mood 2021;17(1):41-47)
참고문헌 (50)
- American Psychiatric Association, "Diagnostic and statistical manual of mental disorders", American Psychiatric Association, ~ (2017)
- Grant BF, "The epidemiology of dsm-iv panic disorder and agoraphobia in the united states : Results from the national epidemiologic survey on alcohol and related conditions", J Clin Psychiatry, 67, pp.363~374 (2006)
- 서호석, "공황장애의 한국형 최신 치료지침", 대한의사협회지, 61(8), pp.493~499 (2018), 대한의사협회[DOI]
- Roy-Byrne PP, "Course and outcome in panic disorder : a review of recent follow-up studies", Anxiety, 1, pp.151~160 (1994)
- Pollack MH, "Long-term course and outcome of panic disorder", J Clin Psychiatry, 58(Suppl 2), pp.57~60 (1997)
- Leon AC, "The social costs of anxiety dis-orders", Br J Psychiatry Suppl, pp.19~22 (1995)
- Ferreri F, "Current research on cognitive as-pects of anxiety disorders", Current Opinion in Psychiatry, 24, pp.49~54 (2011)
- O’Sullivan K, "Neuropsychological impairments in panic disorder : a systematic review", J Affect Disord, 167, pp.268~284 (2014)
- Airaksinen E, "Neuropsychological functions in anxiety disorders in population-based samples : Evidence of epi-sodic memory dysfunction", J Psychiatr Res, 39, pp.207~214 (2005)
- Castaneda AE, "A review on cognitive impairments in depressive and anxiety disorders with a focus on young adults", Journal of Affective Disorders, 106, pp.1~27 (2008)
- Di Giorgio LM, "Evoked potential in panic disorder patients : a systematic review", CNS Neurol Disord Drug Targets, 14, pp.863~871 (2015)
- Asmundson GJ, "Neurocognitive function in panic disorder and social phobia patients", Anxiety, 1, pp.201~207 (1994)
- Alves MR, "Cognitive functions in patients with panic disorder : a literature re-view", Braz J Psychiatry, 35, pp.193~200 (2013)
- Lautenbacher S, "Divided and selective attention in panic disorder. A comparative study of patients with panic disor-der, major depression and healthy controls", Eur Arch Psychiatry Clin Neurosci, 252, pp.210~213 (2002)
- Kaplan JS, "Differential performance on tasks of affective processing and decision-making in patients with panic disorder and panic disorder with comorbid major depressive disorder", J Affect Disord, 95, pp.165~171 (2006)
- Harber L, "Meta-analysis of neuropsychological studies in panic disor-der patients : Evidence of impaired performance during the emotional stroop task", Neuropsychobiology, 78, pp.7~13 (2019)
- Simone AN, "Low working memory rather than adhd symptoms predicts poor academic achieve-ment in school-aged children", Journal of Abnormal Child Psychology, 46, pp.277~290 (2018)
- Friso-van den Bos I, "Classroom versus in-dividual working memory assessment : Predicting academic achieve-ment and the role of attention and response inhibition", Memory, 28, pp.70~82 (2020)
- Alloway TP, "Working memory, but not iq, predicts subsequent learn-ing in children with learning difficulties", European Journal of Psy-chological Assessment, 25, pp.92~98 (2009)
- Fitri FI, "Association between working memo-ry impairment and activities of daily living in post-stroke patients", Med Glas(Zenica), 17, pp.433~438 (2020)
- Memel M, "Working memo-ry predicts subsequent episodic memory decline during healthy cog-nitive aging : Evidence from a cross-lagged panel design", Aging, Neu-ropsychology, and Cognition, 26, pp.711~730 (2019)
- Sheehan DV, "The mini-international neuropsychiatric interview (m.I.N.I.):The development and validation of a structured diagnostic psychiat-ric interview for dsm-iv and icd-10", J Clin Psychiatry, 59(Suppl 20), pp.22~57 (1998)
- HAMILTON M, "The assessment of anxiety states by rating", Br J Med Psychol, 32, pp.50~55 (1959)
- Hamilton M, "A rating scale for depression", J Neurol Neurosurg Psy-chiatry, 23, pp.56~62 (1960)
- Zimmerman M, "Severity classification on the hamilton depression rating scale", J Af-fect Disord, 150, pp.384~388 (2013)
- Katherine Shear M, "Multicenter collaborative panic disorder severi-ty scale", American Journal of Psychiatry, 154, pp.1571~1575 (1997)
- Lee EH, "Reliability and validity of the self-report version of the panic disorder severity scale in korea", Depress Anxi-ety, 26, pp.E120~123 (2009)
- GrÉGoire J, "Effect of age on forward and backward digit spans", Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, 4, pp.140~149 (1997)
- Dobbs AR, "Adult age differences in working memory", Psychol Aging, 4, pp.500~503 (1989)
- Hilbert S, "The digit span backwards task", Eur J Psychol Assess, 31, pp.174~180 (2015)
- Roy-Byrne PP, "Panic disorder in the primary care setting : Comorbidity, dis-ability, service utilization, and treatment", J Clin Psychiatry, 60, pp.492~500 (1999)
- Mineka S, "Comorbidity of anxiety and unipolar mood disorders", Annu Rev Psychol, 49, pp.377~412 (1998)
- Breier A, "Major depression in patients with agoraphobia and panic disorder", Arch Gen Psychiatry, 41, pp.1129~1135 (1984)
- Tsourtos G, "Evidence of an early informa-tion processing speed deficit in unipolar major depression", Psychol Med, 32, pp.259~265 (2002)
- Channon S, "Effects of structure and clus-tering on recall and recognition memory in clinical depression", J Abnorm Psychol, 102, pp.323~326 (1993)
- Dratcu L, "Panic patients in the non-panic state : physiologi-cal and cognitive dysfunction", Eur Psychiatry, 13, pp.18~25 (1998)
- Zhou Z, "Impairment of working memory, decision-making, and executive function in the first-degree relatives of people with panic disorder : a pilot study", Front Psychiatry, 8, pp.219~ (2017)
- Galderisi S, "Alexithymia and cognitive dysfunctions in patients with panic disor-der", Psychother Psychosom, 77, pp.182~188 (2008)
- Gelernter J, "Population studies of polymorphisms of the serotonin transporter protein gene", Am J Med Genet, 88, pp.61~66 (1999)
- Roy-Byrne PP, "Paroxetine response and tolerability among ethnic minority patients with mood or anxiety disorders : a pooled analysis", J Clin Psychiatry, 66, pp.1228~1233 (2005)
- Volpe U, "The contribution of brain imaging to the study of panic disorder", Epidemiol Psichiatr Soc, 13, pp.237~248 (2004)
- Nordahl TE, "Cerebral glucose metabolic differences in patients with panic disorder", Neuropsychopharmacology, 3, pp.261~272 (1990)
- Fischer H, "Brain correlates of an unexpected panic attack : a human positron emission tomo-graphic study", Neurosci Lett, 251, pp.137~140 (1998)
- Kent JM, "Prediction of panic response to a respiratory stimulant by reduced orbitofrontal cerebral blood flow in panic disorder", Am J Psychiatry, 162, pp.1379~1381 (2005)
- Chang C, "Temporal dynamics of basal ganglia response and connectivity during verbal working memory", Neuroimage, 34, pp.1253~1269 (2007)
- McNab F, "Prefrontal cortex and basal ganglia control access to working memory", Nat Neurosci, 11, pp.103~107 (2008)
- Luerding R, "Working memory performance is correlated with local brain morphology in the medial frontal and anterior cingulate cortex in fibromyalgia patients : Structural correlates of pain–cognition interaction", Brain, 131, pp.3222~3231 (2008)
- Luna B, "Neocortical system abnormalities in autism : an fmri study of spatial working memory", Neurology, 59, pp.834~840 (2002)
- Deckersbach T, "Memory dysfunction in panic disorder : an investigation of the role of chronic benzodiazepine use", Depress Anxiety, 28, pp.999~1007 (2011)
- Gladsjo JA, "A neuropsychological study of panic disorder : negative find-ings", J Affect Disord, 49, pp.123~131 (1998)
