항암화학요법으로 인한 말초신경병증 환자의 한방치험 1례
Case Report of Chemotherapy Induced Peripheral Neuropathy Treated with Korean Medicine
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초록
The purpose of this study is to report a clinical case of a patient with CIPN (Chemotherapy Induced Peripheral Neuropathy) successfully treated with Korean medicine interventions including acupuncture, herbal medicine and moxibustion. The patient is a female with CIPN who was diagnosed with ascending colon cancer and suffering from paresthesia of extremities after chemotherapy of platinum compounds. The patient was treated mainly with electroacupuncture (Ex-LE 10), indirect moxibustion and herbal medicine (Ucha-Shinki-hwan granule). The clinical outcomes were measured by NCI CTCAE grade, EORTC QLQ-C30 (CIPN20) scale and patient’s assessment of symptoms. In this case, the NCI CTCAE grade was improved from II to I. The scores of global health status and functional scale in QLQ-C30 were increased and symptom scale was decreased. Especially, this case shows a noticeable decrease in sensory scale in QLQ-CIPN20. In patient’s general assessment, the scale was changed from 10 to 5. Korean medical interventions including acupuncture, herbal medicine and moxibustion could potentially be an effective treatment for CIPN if further researches are conducted.
Abstract
The purpose of this study is to report a clinical case of a patient with CIPN (Chemotherapy Induced Peripheral Neuropathy) successfully treated with Korean medicine interventions including acupuncture, herbal medicine and moxibustion. The patient is a female with CIPN who was diagnosed with ascending colon cancer and suffering from paresthesia of extremities after chemotherapy of platinum compounds. The patient was treated mainly with electroacupuncture (Ex-LE 10), indirect moxibustion and herbal medicine (Ucha-Shinki-hwan granule). The clinical outcomes were measured by NCI CTCAE grade, EORTC QLQ-C30 (CIPN20) scale and patient’s assessment of symptoms. In this case, the NCI CTCAE grade was improved from II to I. The scores of global health status and functional scale in QLQ-C30 were increased and symptom scale was decreased. Especially, this case shows a noticeable decrease in sensory scale in QLQ-CIPN20. In patient’s general assessment, the scale was changed from 10 to 5. Korean medical interventions including acupuncture, herbal medicine and moxibustion could potentially be an effective treatment for CIPN if further researches are conducted.
참고문헌 (33)
- Wolf, S., "Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies", European journal of cancer, 44(11), pp.1507~1515 (2008)
- Visovsky, C., "Putting evidence into practice: evidence-based interventions for chemotherapy-induced peripheral neuropathy", Clinical journal of oncology nursing, 11(6), pp.901~913 (2007)
- Albers, J. W., "Interventions for preventing neuropathy caused by cisplatin and related compounds", The Cochrane database of systematic reviews, 2011(2), pp.Cd005228~ (2011)
- Wong, R., "Acupuncture treatment for chemotherapy-induced peripheral neuropathy--a case series", Acupuncture in medicine : journal of the British Medical Acupuncture Society, 24(2), pp.87~91 (2006)
- Bao, T., "Acupuncture treatment for bortezomib-induced peripheral neuropathy: a case report", Pain research and treatment, 2011, pp.920807~ (2011)
- Donald, G. K., "Evaluation of acupuncture in the management of chemotherapy-induced peripheral neuropathy", Acupuncture in medicine : journal of the British Medical Acupuncture Society, 29(3), pp.230~233 (2011)
- Schroeder, S., "Acupuncture for chemotherapy-induced peripheral neuropathy (CIPN): a pilot study using neurography", Acupuncture in medicine : journal of the British Medical Acupuncture Society, 30(1), pp.4~7 (2012)
- Rostock, M., "Chemotherapy-induced peripheral neuropathy in cancer patients: a four-arm randomized trial on the effectiveness of electroacupuncture", Evidence-based complementary and alternative medicine, 2013, pp.349653~ (2013)
- Muthuraman, A., "Attenuating effect of hydroalcoholic extract of Acorus calamus in vincristine-induced painful neuropathy in rats", Journal of natural medicines, 65(3), pp.480~487 (2011)
- Abad, A., "Effect of Matricaria chamomilla hydroalcoholic extract on Cisplatin-induced neuropathy in mice", Chinese Journal of Natural Medicine, 9(2), pp.126~131 (2011)
- Ozturk, G., "The effect of Ginkgo extract EGb761 in cisplatin-induced peripheral neuropathy in mice", Toxicology and applied pharmacology, 196(1), pp.169~175 (2004)
- Xu, F., "Antinociceptive efficacy of verticinone in murine models of inflammatory pain and paclitaxel induced neuropathic pain", Biological & pharmaceutical bulletin, 34(9), pp.1377~1382 (2011)
- Schroder, S., "Can medical herbs stimulate regeneration or neuroprotection and treat neuropathic pain in chemotherapy-induced peripheral neuropathy?", Evidence-based complementary and alternative medicine, 2013, pp.423713~ (2013)
- Nishioka, M., "The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimen", International journal of clinical oncology, 16(4), pp.322~327 (2011)
- Kono, T., "Efficacy of goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer", Evidence-based complementary and alternative medicine, 2011, pp.418481~ (2011)
- Kaku, H., "Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel", carboplatin therapy: A multicenter collaborative study, 2012, pp.3(1), 60~65
- 박병록, "항암화학요법에 의한 말초신경병증의 봉독크림 치료 : 연속증례", 한의학연구소 논문집, 22(2), pp.111~117 (2014), 한의학연구소
- 윤정원, "Sweet Bee Venom Pharmacopuncture for Chemotherapy-Induced Peripheral Neuropathy", Journal of Acupuncture & Meridian Studies, 5(4), pp.156~165 (2012), 사단법인약침학회[DOI]
- "Common terminology criteria for adverse events (CTCAE)"[URL]
- Postma, T. J., "The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy: the QLQ-CIPN20", European journal of cancer, 41(8), pp.1135~1139 (2005)
- Ocean, A. J., "Chemotherapy-induced peripheral neuropathy: pathogenesis and emerging therapies", Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 12(9), pp.619~625 (2004)
- Velasco, R., "Chemotherapy-induced peripheral neuropathy: an unresolved issue", Neurologia (Barcelona, Spain), 25(2), pp.116~131 (2010)
- Ajani, J. A., "Comprehensive criteria for assessing therapy-induced toxicity", Cancer investigation, 8(2), pp.147~159 (1990)
- Lavoie Smith, E. M., "Assessing patient-reported peripheral neuropathy: the reliability and validity of the European Organization for Research and Treatment of Cancer QLQ-CIPN20 Questionnaire", Qual Life Res, 30 (2013)
- 김정혜, "항암화학요법으로 인한 말초신경병증을 경험하는 대장암 환자의 삶의 질", Asian Oncology Nursing, 11(3), pp.254~262 (2011), 대한종양간호학회
- Argyriou, A. A., "Chemotherapy-induced peripheral neurotoxicity (CIPN): an update", Critical reviews in oncology, 2012, pp.82(1), 51~77
- Yun, Y. H. P. Y., "Validation of the Korean version of the EORTC QLQ-C30", Qual Life Res, 13, pp.863~868 (2004)
- Wickham, R., "Chemotherapy-induced peripheral neuropathy : a review and implications for oncology nursing practice", Clinical journal of oncology nursing, 11(3), pp.361~376 (2007)
- Wang, Y., "Effects of synchronous or asynchronous electroacupuncture stimulation with low versus high frequency on spinal opioid release and tail flick nociception", Exp Neurol, 192(1), pp.156~162 (2005)
- Meng, X., "The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia", hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy, 2011, pp.1414, 58~65
- Kim, J. H., "Relieving effects of electroacupuncture on mechanical allodynia in neuropathic pain model of inferior caudal trunk injury in rat: mediation by spinal opioid receptors", Brain research, 998(2), pp.230~236 (2004)
- 최창원, "말초신경병증으로 추정되는 痺證 치험 1례", 대한한방내과학회지, 30(3), pp.648~655 (2009), 대한한방내과학회
- Yoo S. Y., "Traditional Korean Medical Treatment for Chemotherapy-induced Peripheral Neuropathy - a Case Report", J of Kor. Oriental Oncology, 12(1), pp.83~89 (2007)
