半夏瀉心湯과 씨메티딘의 倂用投與가 흰쥐의 위궤양에 미치는 영향
Effect of the Concurrent Administration of Banhasasim-tang with Cimetidine on Gastric Ulcer in Rats
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Banhasasim-tang(半夏瀉心湯), oriental medicine, has been used for the treatment of the gastric diseases and cimetidine, H2-receptor blocker, has been also used as the gastric ulcer remedy but has some side action. Therefore the concurrent administration of these two drugs may increase antiulcer activities and also decrease cimetidine's side action more than administrating one by one. In order to investigate antiulcer activities, some experiments were conducted. The concurrent administration of Banhasasim-tang extract(BS) and cimetidine(CM) given intraperitoneally (CM 50mg/kg+BS 300mg/kg and CM 50mg/kg+BS 500 mg/kg), significantly inhibited Shay, aspirin and indomethacin ulcers in rats.
Abstract
Banhasasim-tang(半夏瀉心湯), oriental medicine, has been used for the treatment of the gastric diseases and cimetidine, H2-receptor blocker, has been also used as the gastric ulcer remedy but has some side action. Therefore the concurrent administration of these two drugs may increase antiulcer activities and also decrease cimetidine's side action more than administrating one by one. In order to investigate antiulcer activities, some experiments were conducted. The concurrent administration of Banhasasim-tang extract(BS) and cimetidine(CM) given intraperitoneally (CM 50mg/kg+BS 300mg/kg and CM 50mg/kg+BS 500 mg/kg), significantly inhibited Shay, aspirin and indomethacin ulcers in rats.