본문 바로가기
KERD
논문KCI 등재

CIA 생쥐의 關節炎 유발에 대한 淸熱瀉濕湯加味方의 억제 효과

Inhibitory Effect of Ceongryulsaseuptang-kami on Arthritis occurrence in Collagen Induced Arthritis Mouse

박종오|이용구|신현규|김동희|조종철
한의병리학회 (The Society of Pathology in Korean Medicine)|2004.02|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제18권 제1호|pp. 112-136

2

조회

0

다운로드

1

인용

0

참고문헌

주제분류한의학

초록

Abstract

To evaluate effect of CRSST on inhibiting the occurrence of arthritis, we performed the experiments including production of inflammatory cytokine and immunoglobin in collagen induced arthritis model. The results were obtained as follows. CRSST extract shows any cytotoxicity effect on mouse lung fibroblast cells at dose of 400 ㎍/㎖. CRSST group shows inhibitory effect on arthritis incidence than control group for six weeks. Arthritis index of CRSST group reduces from 4 weeks (75±17.4%) to 6 weeks (33.3±10.0%) compared with control group. In CRSST group, production of cytokines which shows suppressive effect on inflammation (IL-4, IL-10 ) are increased and which promotes inflammation (TNF-α, INF-γ) are decreased in blood. In CRSST group, production of immunogloblin (IgG2b, IgG3 and IgM) is reduced compared with control group, and rate of CD4+ and CD3+ T cell is lower in joint and higher in lymph node compared with control group. From above results it could be accepted that CRSST shows anti-arthritis effect via immune system especially through the controlling the inflammatory cytokines and immunoglobins. CRSST could be usefully applied for the prevention and treatment of RA. And also is expected to be clinically helpful on the treatment of RA through modification.

참고문헌 (42)

  1. "Integration of the NF-B and mitogen-activated protein kinase", AP-1 pathways at the Collagenase-1 promoter Divergence of IL-1 and TNF-dependent signal transduction in rabbit primary synovial fibroblasts, 2000, pp.12(10), 1469~1479
  2. "HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice implications in human rheumatoid arthritis", 100, pp.2227~2234 (1997), HLA-DQB1 polymorphism determines incidence
  3. "The influence of Chinese traditional medicine on the production and activity of interleukin 1 Chinese Journal Of Microbiology And Immunology", pp.15~1 24 (1993)
  4. "IL-17 Is Produced by Nickel-Specific T Lymphocytes and Regulates ICAM-1 Expression and Chemokine Production in Human Keratinocytes Synergistic or Antagonist Effects with IFN- and TNF-", 162(l), pp.494~502 (1999)
  5. "Analysis of two T-cell receptor BV gene segment polymorphisms in caucasoid Brazilian patients with rheumatoid arthritis" (2003)
  6. "Immunization against heterologous type II collagen induces arthritis in mice", pp.666~668 (1980)
  7. "The Effect of a T Cell-Specific NF- B Inhibitor on In Vitro Cytokine Production and Collagen-Induced Arthritis", 165, pp.1652~1658 (2000)
  8. "Adverse reactions to TNF-alpha inhibitors in rheumatoid arthritis", 359(9306), pp.540~541 (2002)
  9. "Magnetic resonance imaging;opportunities for rheumatoid arthritis disease assessment and monitoring long-term treatment outcomes", 4, pp.6~10 (2002)
  10. "Type I Collagen-induced MMP-2 Activation Coincides with Up-regulation of Membrane Type 1-Matrix Metalloproteinase and TIMP-2 in Cardiac Fibroblasts", 278(47), pp.46699~46708 (2003)
  11. "Sera of Patients with Rheumatoid Arthritis Contain Antibodies to Recombinant Human T-Lymphotrophic Virus Type I", II Envelope Glycoprotein p21, 182-1881996, pp.79(2), 182~188
  12. "Tripterygium wilfordii Hook F Extract Suppresses Proinflammatory Cytokine- Induced Expression of Matrix Metalloproteinase Genes in Articular Chondro -cytes by Inhibiting Activating Protein-1 and Nuclear Factor-B Activities", 59, pp.1196~1205 (2001)
  13. "NF- B Regulation by I B Kinase in Primary Fibroblast-Like Synoviocytes", 163, pp.427~433 (1999)
  14. "Suppressive effects of Tripterygium wilfordii Hook f on collagen arthritis in mice, on collagen arthritis in mice", 39(2), pp.117~126 (1998)
  15. "Resistance of Rheumatoid Synovial Dendritic Cells to the Immunosuppressive Effects of IL-10", 163(l), pp.5599~5607 (1999)
  16. "The genetic and immunopathological processes underlying collagen-induced arthritis.", 103, pp.407~416 (2001)
  17. "Role of cytokines in Reumatoid Arthritis", 14, pp.398~399 (1996)
  18. "Enhancing Effect of IL-17 on IL-1-Induced IL-6 and Leukemia Inhibitory Factor Production by Rheumatoid Arthritis Synoviocytes and Its Regulation by Th2 Cytokines", 161(l), pp.409~414 (1998)
  19. "Animal models of chronic inflammatory arthritis", pp.38~45
  20. "The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-a or IL-1 -stimulated rheumatoid synovial fibroblasts", 465, pp.23~27 (1999)
  21. "Differential in vitro effects of IL-4 and IL-13 on proinflammatory cytokine production and fibroblast proliferation in rheumatoid synovium", 20(2), pp.49~54 (2001)
  22. "HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis a novel model for human polyarthritis", 183, pp.27~37 (1996)
  23. "Inhibition of ADAMTS4 by tissue inhibitors of metalloproteinases(TIMP-1, 2, 3 and 4)", 494(3), pp.192~195
  24. "Regulation of Cytokine and Acute-Phase Protein Following Anti-TNF- Therapy in Rheumatoid Arthritis", 165, pp.1203~1209 (2000)
  25. "Antibody therapy for rheumatoid arthritis", 3(3), pp.323~328 (2003)
  26. "Traditional Chinese medicines as immunosuppressive agents", 29(1), pp.11~16 (2000)
  27. "Autoantibodies to GPI in rheumatoid arthritis linkage between an animal model and human disease", 2, pp.746~753 (2001)
  28. "IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis", 103, pp.1345~1352 (1999)
  29. "Macrophage Migration Inhibitory Factor Up-regulates Expression of Matrix Metalloproteinases in Synovial Fibroblasts of Rheumatoid Arthritis", 275, pp.444~450 (2000)
  30. "Daeganghwal -tang inhibits the stem cell factor-induced migration and inflammatory cytokines secretion in mast cells Journal of Ethnopharmacology", 85(1), pp.157~161 (2003)
  31. "Studies on the Contribution of c-fos", AP-1 to Arthritic Joint Destruction, 1997, 1210~1216
  32. "Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways", 165, pp.5227~5237 (2000)
  33. "A phase I study of ethyl acetate extract of the chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis", 28(10), pp.2160~2167 (2001)
  34. "Collagen arthritis as a relevant model for rheumatoid arthritis", pp.911~916
  35. "The molecular mechanism of osteoclastogenesis in rheumatoid arthritis", 4(5), pp.281~289 (2002)
  36. "c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis", 108, pp.73~81 (2001)
  37. "苔巖隨聞驗方錄", pp.454~ (2000), 醫聖堂
  38. "류마티스樣 關節炎에 應用되는 防己의 效能에 관한 實驗的 硏究" (1987)
  39. "基本免疫學", pp.52~54 (1996), 大學書林
  40. "消炎逐水湯이 류마토이드 關節炎의 cytokine에 미치는 影響" (2001)
  41. "舒筋立案散이 류마토이드 關節炎의 cytokine에 미치는 影響" (2001)
  42. "必須臨床免疫學", pp.165~167 (1998), 靑丘文化社

관련 논문AI추천

加味活血湯이 Rheumatoid Arthritis(RA) 病態 모델에 미치는 影響신상문, 유동열, 이보라, 정진홍, ？김동희대한한방부인과학회 · 대한한방부인과학회지2003 · 제16권 제2호Collagen II로 유도된 CIA 관절염 생쥐의 대한 加味海桐皮散의 억제 효과김남욱, 김동희한의병리학회 · 동의생리병리학회지2007 · 제21권 제5호疏風活血湯加味方이 collagen으로 誘發된 생쥐의 關節炎 억제에 관한 연구곽중문, 김동희, 박종오, 오민석한의병리학회 · 동의생리병리학회지2002 · 제16권 제4호祛風除濕湯의 류마토이드 관절염 치료효과에 대한 실험적 연구오민석, 윤일지, 홍순성한의병리학회 · 동의생리병리학회지2006 · 제20권 제5호Inhibitory Effect of Coicis Semen Composition on Inflammatory Responses in the Collagen-induced Arthritis Mouse ModelJung Won Moon, Min Suck Oh한의병리학회 · 동의생리병리학회지2006 · 제20권 제5호Adjuvant에 의해 유발된 關節炎 白鼠모델에 있어서 大防風湯의 진통효과김남권, 김미선, 김재주, 박영일, 성병곤한의병리학회 · 동의생리병리학회지2002 · 제16권 제1호

이 간행물의 다른 논문 (20건)

素問 陰陽離合論의 陰陽離合에 관한 연구하근호, 김광중pp. 8-15中醫 辨證論治와 東醫寶鑑의 辨證論治에 대한 연구고흥pp. 16-21全身形態 진단과 辨證施治의 連繫를 위한 葉桂의 形態體質論 연구김경철, 신순식, 이용태pp. 22-27訓民正音의 制字背景과 易學的 原理손유석, 강정수pp. 28-38가미신선불로단이 알츠하이머병 진단지표인 아밀로이드 단백독성과 APPr에 미치는 영향엄현섭pp. 53-57
원문 보기