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澤君六味地黃湯이 산화질소의존형 고혈압백서의 혈압과 신장기능에 미치는 영향

Effects of Taekunyukmijiwhang-tang on Blood Pressure and Renal function in NO-dependent Hypertensive Rats

강대길|윤용갑|문미경|이호섭|손은진|노숙연|이안숙|尹明浩
한의병리학회 (The Society of Pathology in Korean Medicine)|2004.02|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제18권 제1호|pp. 84-92

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참고문헌

주제분류한의학

초록

Abstract

The persent study examined the effects of Taekunyukmijiwhang-tang (TY) on blood pressure and renal function in nitric oxide (NO)-dependent hypertensive rats. A phamacological inhibition of nitric oxide synthase (NOS) for 4-6 weeks produces renal vasoconstriction, renal dysfunction, and progressive severe hypertension. Treatment of rats with NG-Nitro-L-arginie methylester (L-NAME) (100 mg/L, 6 weeks), which is a nonspecific NOS inhibitor, cause a sustained increase in systolic blood pressure (SBP), along with the decrease in expression of ecNOS in the kidney and thoracic aorta. The expression of Na, K-ATPase α1 subunit in the kidney was also reduced in the L-NAME induced hypertensive rats group. The renal functional parameters including urine osmolality (Uosm), creatinine clearance (Ccr), which is an index of glomerular filtration (GFR) were decreased in rat with L-NAME induced hypertension. while solute-free water reabsoption (TcH2O) was unchanged in all experimenstal group. However, the group combined treated with TY and L-NAME did not develop hypertension and expression of ecNOS in the aorta was restored. The expression of Na+, K+-ATPase α1 subunit in the kidney was markedly restored in L-NAME-induced hypertension rats by administration of TY along with the restoration of urinary volume (UV) and sodium excretion (UNaV), whlie Na+, K+-ATPase β1 subunit was not altered. These results suggest that TY attenuates an increase in SBP in the L-NAME induced hypertension and restores partially renal function, which seems to be caused by up-regulation of expression of Na+, K+-ATPase α1 subunit in the kidney and ecNOS in thoracic aorta.

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