平胃散 藥鍼液의 활성산소 및 활성질소 소거능
Scavenging Property of Pyungwi-san Herbal-acupuncture Solution on ROS and RNS
2
조회
0
다운로드
7
인용
0
참고문헌
초록
Abstract
Pyungwi-san(PWS) have been using as a basic prescription of digestive disorder in Korean traditional medicine. This study was performed to examine the in vitro antioxidant activity of the extract using different antioxidant tests including by 1,1-diphenyl-2-picryl-hydrazil (DPPH) radical scavenging, superoxide anion radical scavenging, metal chelating hydrogen peroxide scavenging, lipid peroxydation protective effect and scavenging effect of nitric oxide and peroxynitrite. Herbal-acupuncture solution of PWS(PWS-HS) exhibited a concentration-dependent inhibition of DPPH radical adduct formation and it showed dose-dependent free radical scavenging activity onto superoxide anions. In addition, the result of metal chelating hydrogen peroxide scavenging and ammonium thiocyanate experiments showed that PWS-HS was an active scavenger of hydroxyl radicals. Furthermore, it was also found to be effective in scavenging nitric oxide and peroxynitrite, well-known cytotoxic species that can oxidize several cellular components such as proteins, lipids and DNA.
참고문헌 (20)
- "Cardiovascular Disease and Natural Antioxidants", 5, pp.19~35 (2001)
- "Antioxidant Consuption and Risk of Coronary Heart Disease: Emphasis on Vitamin C, Vitamin E, and β-carotene", 99, pp.591~595 (1999)
- "Protagonist of Antioxidant", pp.81~85 (2000)
- "Protective dffect of Lingusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide", 75, pp.1775~1786 (2004)
- "A Study on the Effects of Pyungwee-san and Compounding of Medicine in Pyungwee-san on the Movement of Gastrointestinal Smooth Muscles, Anticatharsis and Central Nervous System", 6, pp.184~196 (2000)
- "Effects of Pyeongwoe-San Aqua - Acupuncture at Chok-Samni ( ST 36 ) points on Gastric in Rabbits", 13, pp.321~334 (1996)
- "對譯證脈方藥合編", pp.142~143 (2000), 南山堂, 서울
- "Free-radical scavenging action of medicinal herbs from Ghana", 32, pp.661~667 (1999)
- "E. Rates of interactions of superoxide with vitamin E vitamin C and related compounds as measured by chemiluminescence. Biochim. Biophys. Acta. 1115", pp.201~207 (1992)
- "assay for determination of rate constants for reaction of hydroxyl radicals. Anal. Biochem. 165", pp.215~219 (1987)
- "M. A novel type of antioxidant isolated from leaf wax of Eucalyptus leaves. Agric. Biolog. Chem. 45", pp.735~740 (1981)
- "Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species", 1, pp.145~157 (1997)
- "A fluorescence-based method for measuring nitric oxide in extracts of skeletal muscle", 5, pp.475~481 (2001)
- "Oxidative injury in the nervous system", 98, pp.145~153 (1998)
- "Nitric oxide, oxidative stress and apoptosis", 84, pp.22~24 (2003)
- "The use of the stable free radical diphenylricrylhydrazyl (DPPH) for estimating antioxidant. Songklanakarin J", 26, pp.211~219 (2004)
- "Effect of plant extracts on the oxidative stability of sunflower oil and emulsion", 64, pp.323~329 (1999)
- "SOD よ活性酸素調節濟よの 藥理作用 よ 臨床應用", pp.~9 (1989)
- "S. Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit. Br J Pharmacol 97", pp.1119~1124 (1989)
- "Antioxidants and cardiovascular disease", 6, pp.895~900 (2005)