四物湯이 알러지 염증반응에 미치는 영향
Effect of Samul-Tang on the Allergic Inflammatory Response
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Abstract
Samul-Tang (SMT) has been used for nourishing of the blood, hematopoiesis as a herbal medicine history. The purpose of this study is to find out anti-allergic inflammatory reaction of SMT. To clarify the mechanism, the effect of SMT on vascular permeability of rat cutaneous tissue and histamine and cytokines (IL-6, IL-8, TNF-α) release from mast cells were observed. The results are the pretreatment with SMT significantly decreased the compound 48/80-induced degranulation and histamine release from RPMC, SMT also inhibited the anti-DNP IgE-induced increment of vascular permeability of rat cutaneous tissue. SMT significantly reduced the PMA plus A23187-induced increment of expression of IL-6, IL-8, and TNF-α in HMC-1 Cell. The Present study provide evidence that SMT inhibits mast cell-derived inflammatory allergic reactions by blocking histamine release and pro-inflammatory cytokine expression, and suggest the mechanisms of action. Furthermore, in vivo and in vitro anti-allergic effect of SMT suggests a possible therapeutic application of this agent in inflammatory allergic diseases.
참고문헌 (31)
- "Immunology, 6th ed", pp.323~383 (2001), U.S.A., Mosby
- "Inhibitory effect of Gamibojungikaitang extract on mast cell-mediated allergicreaction in murine Model", 8(1), pp.94~101 (2005)
- "Mast cells and their mediators in cutaneous wound healing-active participants or innocent by standers", 8, pp.1~16 (1998)
- "비만세포의 두얼굴", 20, pp.684~690 (2000)
- "太平惠民和劑局方編. 太平惠民和劑局方. 북경", pp.310~311 (1985), 인민위생출판사
- "李相弦. 四物湯 構成藥物의 配合이 白鼠의 溶血性 貧血에 미치는 影響. 圓光大學校 大學院 1993."
- "姜昌洙. 四物湯 煎湯液이 家兎의 血壓降下에 미치는 影響. 圓光大學校 韓醫科大學 學位論文集 1", pp.381~398 (1981)
- "金世吉. 四物湯이 貧血家兎의 造血效果에 미치는 影響. 圓光大學校 韓醫科大學 學位論文集 pp 143-152" (1982)
- "Inhibition of immediate-type allergic reaction by Rosa davurica Pall. in a murine model", 67, pp.53~60 (1999)
- "우방자 추출물의 compound 48", 80 유도 비만세포 활성화와 혈관 투과성 억제효과, 2004, pp.17(1), 55~65
- "Cheongyeolsaseuptang inhibits production of TNF-α, IL-6 and IL-8 as well as NF-kB activation in human mast cells", 97(1), pp.83~88 (2005)
- "P. Beitrage zur kenntnis der Anilinfarbunger und ihrer Verwendung in drmikroskopischen Technik. Arch Mikrosk Anast 13", pp.263~277 (1877)
- "P.M. Some studies on the release of histamine from mast cells stimulated with polylysine. Br. J. Pharmacol 70", pp.329~334 (1980)
- "이무삼. 상백피가 흰쥐 복강 비만세포의 히스타민 유리와 Calcium uptake에 미치는 영향. 대한면역학회지 15", pp.91~99 (1993)
- "상백피의 colchicine 유도 비만세포 활성화 억제효과", 32, pp.735~747 (1999)
- "K. Effect of the tridecamer of compound 48", 80 on phospholipid metabolism during the early stage of histamine release from rat mast cells. Biochem Pharmacol 35, 1986., 3739~3744
- "C.W. Possible role of arachidonic acid and its metabolites in mediator release from rat mast cells. J Immunol 122", pp.431~436 (1979)
- "C.W. Modulation of cyclic AMP in purified rat mast cells. Ⅱ. Studies on the relationship between intracellular cyclic AMP concentrations and histamine release. J. Immunol 114", pp.1480~1485 (1975)
- "W.W. Antiallergic drug cromolyn may inhibit histamine secretion by regulating phosphorylation of a mast cell protein. Science 207", pp.80~82 (1980)
- "P. Phosphorylation of a single mast cell protein in response to drugs that inhibit secretion. Biochem Pharmacol 30", pp.2737~2738 (1981)
- "O. Differential calcium effects on prostaglandin D2 generation and histamine release from isolated rat peritoneal mast cells. Biochem Biophys Res Commun 143", pp.467~474 (1987)
- "면역과 알레르기", pp.159~173 (1998), 서울, 신일상사
- "Tongkyutang inhibits mast cell-dependent allergic reactions and inflammatory cytokine secretion", 319, pp.35~41 (2002)
- "이중달. 그림으로 설명한 병리학. 서울", pp.~29 (1991)
- "Age-associated increased interleukin-6 gene expression, late-life deseses, and frailty", 51, pp.245~270 (2000)
- "J. Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence. Mol Cell Biol 10", pp.3818~3823 (1990)
- "Cellular and cytokine immunoregulation in patients with chronic obstructive pulmonary disease and bronchial asthma", 11(5), pp.307~312 (2002)
- "rHRF로 유발로 활성화된 생쥐의 B 임파구와 비만세포에서 辛夷 추출물의 항알러지 작용에 관한 연구", 15(6), pp.917~926 (2001)
- "Anti-inflmmatory activity of Korean folk medicine ‘Sabeksan’", 78(3), pp.257~262 (2005)
- "Human mast cells release Interleukin-8 and induce neutrophil chemotaxis on contact with activated T cells", 60, pp.1316~1319 (2005)
- "Sargassum hemiphyllum Inhibits Atopic Allergic Reaction via the Regulation of Inflammatory Mediators", 97(2), pp.219~226 (2005)
