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인삼 다당체 경구 투여 전ㆍ후 혈장의 proteome 분석- 무작위배정, 이중 맹검, 위약비교시험

Analysis of Plasma Proteome before and after Oral Administration of Acidic Polysacharide from Panax Ginseng, Double-blind, Placebo-controlled, Randomised Trial

조종관|유화승|양하영|유병철|이선구|조영호|강태규
한의병리학회 (The Society of Pathology in Korean Medicine)|2007.10|동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)|제21권 제5호|pp. 1185-1193

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참고문헌

주제분류한의학

초록

Abstract

Ginsing polysaccharide, known to have an immune regulating effect, was administered to 23 randomly selected healthy male subjects with a mean age of 23 years in accordance with an IRB approval. Then, these subjects underwent physico-chemical tests and serum proteome was analyzed from the blood sample taken from these subjects. Analyses of proteome involved image analysis, protein sections and protein identification in sequence after two-dimensional electrophoresis was carried out. During the physico-chemical test, 4 subjects were excluded from the study. In the proteome analysis, identified were 5 spots such as SP40, 40, Cytokeratin 9, hypothetical protein LOC544932, Apolipoprotein E ,similar to Human albumin, which showed differences in the amount of protein expression. In conclusion, changes of 5 proteins were remarkable before and after administration of ginsing polysaccharides. In certain cases, hepatic and renal slight injury occurred. Thus, further clinical study on dosage regimen would be necessary for securing the basis for concentration-dependent effectiveness and safety.

참고문헌 (32)

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