백질려 추출물이 Streptococcus mutans에 대한 항치아우식에 미치는 영향
Anticariogenic Properties of the Ethanol Extract of Tribuli fructus against Streptococcus mutans
1
조회
0
다운로드
7
인용
0
참고문헌
초록
Abstract
Streptococcus mutans is considered one of the primary etiologic agents of dental caries. we studied the effect of the ethanol extracts of Tribuli fructus (T. fructus) on the growth, biofilm formation, acid production, adhesion and insoluble glucan synthesis of S. mutans. The ethanol extracts of T. fructus showed concentration dependent inhibitory activity against the growth and acid production of S. mutans, and produced significant inhibition at the concentration of 0.025, 0.05, 0.1, 0.2, 0.3, 0.5 mg/ml compared to the control group. In the biofilm assay, the ethanol extracts of T. fructus inhibited formation of biofilm synthesized by S. mutans at the concentration of 0.05 mg/ml. The extracts markedly inhibited S. mutans adherence to HA treated with saliva, and cell adherence was repressed by more than 50% at the concentration 0.05 mg/ml. On the activity of glucosyltransferase which synthesizes water insoluble glucan form sucrose, ethanol extract of T. fructus showed more than 10% inhibition over the concentration of 0.025 mg/ml. Hence, we conclude that T. fructus might be a candidate of anticaries agent. Further studies are necessary to clarify the active constituents of T. fructus responsible for such biomolecular activities.
참고문헌 (26)
- "S. Bacteriology of dental infections. Eur Hear J 14", pp.430~450 (1993)
- "구강미생물학", pp.261~262 (1998), 고문사
- "Biofilms of the oral cavity. Formation, development and involvement in the onset of diseases related to bacterial plaque increase", 51, pp.187~192 (2002)
- "Saliva-promoted adhesion of Streptococcus mutans MT8148 associates with dental plaque and caries experience", 41, pp.212~218 (2007)
- "J.A. Insoluble glucan synthesis by mutansucrase as determinant of the cariogenicity of Streptococcus mutans. J Gen Microbiol 127", pp.407~415 (1981)
- "S. Synthesis adherent insoluble glucan by the concerted action of the two glucosyltransferase components of Streptococcus mutans. FEBS Lett 143", pp.101~104 (1982)
- "A. Effect of a glucosyltransferase inhibitor on glucan synthesis and cellular adherence of Streptococcus mutans. Infect Immun. 38", pp.882~885 (1982)
- "P.B. Effect of rotary electric toothbrush versus manual toothbrush on periodontal status during orthodontic treatment. Am J Orthod Dentofac Orthop 96", pp.342~347 (1989)
- "NaF, CPC 및 UDCA를 함유한 구강양치액의 치면세균막 제거효과 및 치은염 완화 효과 평가에 관한 임상적 실험연구", 22, pp.121~133 (1998)
- "김종배. 잇솔질 및 혓솔질의 구취감소효과에 관한 연구. 대한구강보건학회지 17", pp.268~277 (1993)
- "H. Dental caries prevention by traditional chinese medicines. Plant Med 44", tsune, pp.100~106 (1982)
- "Rolla G. Streptococcus mutans in plaque and saliva after mouthrinsing with SnF2. Scand J Dent Res 90", pp.292~298 (1982)
- "G. Effect of SnF2 administered as mouthrinse or topically applied on Streptococcus mutans Streptococcus sanguis and lactobacilli in dental plaque and saliva. Scand J Dent Res 9", pp.123~129 (1983)
- "Enamel fluoride retention after application of fluoride-containing rubber cups", 15, pp.11~14 (2002)
- "NaF 0.05%양치액 사용시 고정성 교정장치 정착 환자에서의 Streptococcus mutans변화에 관한 연구", 27, pp.539~548 (1997)
- "R.F. Plaque distribution on bonded brackets", pp.667~677 (1979)
- "Clinical effectiveness of fluoride-releasing elastomers. I, Salivary Streptococcus mutans numbers", 107, pp.293~297 (1995)
- "한약재를 이용한 기능성식품의 개발동향" (2003)
- "생약학연구회. 현대 생약학. 학창사" (1988)
- "양승각. 상백피의 Sanggenon C에 의한 Streptococcus mutans의 생육 및 균부착 저해 효과. 약학회지 34", pp.434~439 (1990)
- "H. Periodontal disease in pregnacy. Acta Odontaol Scan 22", pp.121~126 (1964)
- "해외 건강 기능성 소재 - 백질려" (2004)
- "Initiation of biofilm formation in Pseudomonas fluorescens WCS365 proceeds via multiple, convergent signalling pathways: a genetic analysis", 28, pp.449~461 (2004)
- "A.D. The bacterial etiology of destructive periodontal disease", pp.322~331 (1992)
- "자일리톨이 함유된 Curcuma xanthorrhiza추출물이 Streptococcus mutans 바이오필름에 미치는 효과", 30, pp.497~505 (2006)
- "Comparative evaluation of in-vitro effects of Brazilian green propolis and Baccharis dracunculifolia extracts on cariogenic factors of Streptococcus mutans", 27, pp.1834~1839 (2004)