라벤더 에탄올 추출물이 α-MSH 유도 멜라닌 생성에 미치는 효과
Effect of the Ethanol Extract from Lavandula vera on α-MSH Induced Melanogenesis
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Down-regulation of melanin synthesis is required for recovery of pigmentary disorders and it is well known that α-MSH induced melanin synthesis and dendrite outgrowth on melanocytes. This study was conducted to evaluate the depigmenting properties of ethanol extract from a Lavandula vera. The ethanol extract from Lavandula vera inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the ethanol extract of Lavandula vera effectively suppressed the α-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the α-MSH-induced mRNA expression of tyrosinase was significantly attenuated by Lavandula vera treatment. These results suggest that Lavandula vera exerts its depigmenting effects through the suppression of tyrosinase and cytoplasmic dendricity. And it may be a potent depigmetation agent in hyperpigmentation condition.
Abstract
Down-regulation of melanin synthesis is required for recovery of pigmentary disorders and it is well known that α-MSH induced melanin synthesis and dendrite outgrowth on melanocytes. This study was conducted to evaluate the depigmenting properties of ethanol extract from a Lavandula vera. The ethanol extract from Lavandula vera inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the ethanol extract of Lavandula vera effectively suppressed the α-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the α-MSH-induced mRNA expression of tyrosinase was significantly attenuated by Lavandula vera treatment. These results suggest that Lavandula vera exerts its depigmenting effects through the suppression of tyrosinase and cytoplasmic dendricity. And it may be a potent depigmetation agent in hyperpigmentation condition.
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