월비가반하탕이 고지방식이로 유도된 비만 쥐에 미치는 영향
The Effects of Wolbiga-banha-tang on Obese Rats Fed a High-fat Diet
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This study investigated the effects of Wolbiga-banha-tang (WBBT) on high fat diet-induced rats. We divided the rats into 4 groups: normal (fed a general-fat diet), control (fed a high-fat diet and no treatment), WBBT×1 (fed a high-fat diet and 250 mg/kg of Wolbiga-banha-tang extracts), and WBBT×2 (fed a high-fat diet and 500 mg/kg of Wolbiga-banha-tang extracts). We measured the body weight, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, free fatty acids, total lipids, AST, ALT, and CBC in the serum of the obese rats for 7 weeks. There was a significant decrease in the control group, WBBT×1, and WBBT×2 in triglycerides and free fatty acids. The results suggest that WBBT is effective for lowering triglycerides and free fatty acids. Therefore, WBBT may be applied to the treatment of lipid metabolism in obesity and further clinical studies are needed.
Abstract
This study investigated the effects of Wolbiga-banha-tang (WBBT) on high fat diet-induced rats. We divided the rats into 4 groups: normal (fed a general-fat diet), control (fed a high-fat diet and no treatment), WBBT×1 (fed a high-fat diet and 250 mg/kg of Wolbiga-banha-tang extracts), and WBBT×2 (fed a high-fat diet and 500 mg/kg of Wolbiga-banha-tang extracts). We measured the body weight, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, free fatty acids, total lipids, AST, ALT, and CBC in the serum of the obese rats for 7 weeks. There was a significant decrease in the control group, WBBT×1, and WBBT×2 in triglycerides and free fatty acids. The results suggest that WBBT is effective for lowering triglycerides and free fatty acids. Therefore, WBBT may be applied to the treatment of lipid metabolism in obesity and further clinical studies are needed.
참고문헌 (31)
- Korean Medicine for Obesity Research, "Clinical bariatrics", pp.143~ (2008)
- 2013 National Health statistics National Health and Nutrition Study The 6th term First year(2013), "Yang BG. 2013 National Health statistics National Health and Nutrition Study The 6th term First year", The Ministry of Health and Welfare Division of Health Policy, 51~ (2014)
- Yang YG, "Yellow Emperor's Inner Canon Somun interpretation", pp.25~ (1991), Iljungsa
- Yang YG, "Yellow Emperor's Inner Canon Yeongchu interpretation", pp.416~ (1991), Iljungsa
- S Kim, "A Study on etiological factors, symptoms of a disease, and treatments of obesity based on dong-Yi Bo Gam", Journal of The Society of Korean Medicine, 19(2), pp.126~136 (1998)
- Traditional Medical Institute Dongryeol Gwak, "Jinkui Yaolue translation", pp.181~183 (2002), Seongbosa
- Lee JH, "Essential Formulae in Oriental Medicine with Illustrations", pp.578~ (2007), Uibang Publishing Company
- 송미영, "비만에 작용하는 주요 본초의 항비만 효과 분석", 한방비만학회지, 2(2), pp.51~57 (2013), 한방비만학회
- 박웅덕, "高콜레스테롤 食餌로 유도된 비만 흰쥐에 대한 越婢湯의 효과", 동의생리병리학회지, 19(2), pp.466~474 (2005), 한의병리학회
- The effect of herb prescription ‘Wol-Bi-Tang' in obesity, "Lee JH", Department of Oriental Pharmacy Graduate School of Wonkwang University, ~ (2007)
- 박지현, "越婢湯이 高脂肪食餌로 유도된 비만 생쥐에 미치는 영향", 한방재활의학과학회지, 21(2), pp.31~48 (2011), 한방재활의학과학회
- 안정란, "고지방식이 비만마우스에서 越婢加朮湯이 식이효율과 내장지방에 미치는 영향", 한방재활의학과학회지, 21(1), pp.1~22 (2011), 한방재활의학과학회
- Kim CM, "Chinese Medicine Unabridged Dictionary", pp.1508~ (1998), Jungdam
- Wadden TA, "The latest bariatrics", pp.9~13 (2005), Korean Medbook
- 왕성배, "건강검진 수검자들의 비만도와 고혈압, 고혈당 및 고콜레스테롤혈증과의 관련성", 한국산학기술학회논문지, 12(6), pp.2677~2684 (2011), 한국산학기술학회
- Heo J, "Dongui Bogam", pp.72~ (1994), Namsandang
- Korean Medicine for Obesity Research, "Obesity Treatment Guideline of Korean Society for the study 2012", pp.43~108 (2012), Cheongun
- Shin MG, "Yongyang Simdeuk Sipgang", pp.280~281 (2001), Uiseongdang
- Shin MG, "Clinical Herbalism", pp.323~ (2006), Yeongrim Company
- Song YK, "Clinical Application of Ma Huang in the Obesity Treatment", Journal of Korean Medicine for Obesity Research, 7(1), pp.1~7 (2007)
- Lee YJ, "The efficiency of Ephedrae herba on the obese zucker rats’ lipid of blood serum and fatty acid metabolism of skeletal muscles" (2005), Graduate School Dongguk University
- Kim YJ, "The Effects of Ephedra sinica on Lipid of Blood Serum and Epididymis Fat Cells in the Rats" (2006), Graduate School Dongguk University
- 기영범, "麻黃과 石膏 혼합물이 지방전구세포 분화와 흰쥐의 비만에 미치는 영향", 한방재활의학과학회지, 24(3), pp.11~27 (2014), 한방재활의학과학회
- Kim YJ, "Anti-obesity effect of pinellia tuber in adipose tissues of zucker rats : gene expressions of PPARα, PGC1α and UCP" (2006), Graduate School Seoul University
- 윤상구, "반하가 비만 쥐의 혈중지질 및 골격근 내의 지방산 대사에 미치는 영향", 대한한의학회지, 27(2), pp.211~224 (2006), 대한한의학회
- Fukui A, "Relationship between obesity, total plasma cholesterol and blood pressure in male adults", Japan Soc Occup Health, 42(4), pp.119~124 (2000)
- Sakai K, "Factors related to serum lipid levels in women of middle and old age -a community study-", Japanese J of Publ Hlth, 38(2), pp.112~117 (1991)
- 윤현숙, "건강검진자료에 의한 일반 성인의 비만지표와 혈청지질치의 관련성", 한국산학기술학회논문지, 16(2), pp.1145~1152 (2015), 한국산학기술학회[DOI]
- Lee GB, "Clinical Pathology Handbook", pp.116~ (1991), Gomunsa
- Clinical practice of inspection report, "Kim GH", Gomunsa, 164~177 (1980)