엉겅퀴 잎 수용성 추출물의 콜라겐 유도 관절염 억제효과
Suppressive Effect of Water Extract from Leaf of Cirsium japonicum var. ussuriense on Collagen-induced Arthritis
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Cirsium japonicum var. ussuriense is often used in treatment of human disease such as hemorrhage, blood congestion and inflammation. The present study has been undertaken to investigate the effect of the leaf extract from C. japonicum var. ussuriense (CLE) on the development of collagen-induced arthritis (CIA) in DBA1/J mice. CLE administration suppressed markedly the arthritis incidence and arthritis score in CIA mice. Also, CLE significantly suppressed the release of PGE2, TNF-α, IL-4 and IL-6 in CIA mice. However, CLE significantly increased the production of IL-10, but not IL-4. These results suggest that CLE suppress inflammatory mediators and regulates Th1 and Th2 cytokines. These properties may contribute to the anti-arthritis action of CLE.
Abstract
Cirsium japonicum var. ussuriense is often used in treatment of human disease such as hemorrhage, blood congestion and inflammation. The present study has been undertaken to investigate the effect of the leaf extract from C. japonicum var. ussuriense (CLE) on the development of collagen-induced arthritis (CIA) in DBA1/J mice. CLE administration suppressed markedly the arthritis incidence and arthritis score in CIA mice. Also, CLE significantly suppressed the release of PGE2, TNF-α, IL-4 and IL-6 in CIA mice. However, CLE significantly increased the production of IL-10, but not IL-4. These results suggest that CLE suppress inflammatory mediators and regulates Th1 and Th2 cytokines. These properties may contribute to the anti-arthritis action of CLE.
참고문헌 (29)
- Habashy, R. R., "Anti-inflammatory effects of jojoba liquid wax in experimental models", Pharmacol Res, 51, pp.95~105 (2005)
- Murakami, M., "Prostaglandin E synthase: a novel drug target for inflammation and cancer", Curr Pharm Des, 12(8), pp.943~954 (2006)
- Kosmaczewska, A., "The role of Th1, Th17, and Treg cells in the pathogenesis of rheumatoid arthritis including anti-inflammatory action of Th1 cytokines", Postepy Hig Med Dosw (Online), 65, pp.397~403 (2011)
- Lubberts, E., "Th17 cytokines and arthritis", Semin Immunopathol, 32(1), pp.43~53 (2010)
- van Roon, J. A., "Suppression of inflammation and joint destruction in rheumatoid arthritis may require a concerted action of Th2 cytokines", Curr Opin Investig Drugs, 3(7), pp.1011~1016 (2002)
- Ishida, H., "Clinical implication of IL-10 in patients with immune and inflammatory diseases", Rinsho Byori, 42(8), pp.843~852 (1994)
- The Korean Orthopaedic Association, "orthopedics", pp.109~176 (2000), Cholsin medicine publisher
- The Korean Society of Pathologists, "Pathology", pp.85~1672 (1997), Komoonsa
- Oriental medicine rehabilitation medical science, "The whole country a college of Oriental medicine rehabilitation medical science classroom", pp.95~96 (1995), Seowondang
- Internal medicine, "Shanghai China medicine Book", pp.234~238 (1983), Shanghai science technology publisher
- Chung, S.H., "The study on classification and treatment of arthalgia syndrome", Korean Acad Rehabil Med, 2, pp.56~66 (1991)
- Lee, S.J., "Korean folk medicine", pp.145~146 (1996), Seoul National University Press
- Ishida, H., "Studies on antihemmorhagic substance in herbs classified hemostatics in Chinese medicine. VII. On the antihemorhagic principle in Cirisium japonicum DC", Chem Pharm Bull, 35, pp.861~864 (1987)
- 윤택기, "CD 동의보감" (1994), 여강문화사, (주)솔빛조선미디어
- 정찬조, "쓰임새 많은 자원식물 엉겅퀴", pp.372~ (1993), 한국자생식물보존회 자생식물
- 정미숙, "플라보노이드 함유 엉겅퀴를 이용한 기능성 다류 개발", 한국식생활문화학회지, 22(2), pp.261~265 (2007), 한국식생활문화학회
- Liu, S., "Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC", Int Immunopharmacol, 6, pp.1389~1393 (2006)
- 이희경, "엉겅퀴 추출물의 항상화성, 항돌연변이원성 및 항암활성 효과", 한국약용작물학회지, 11(1), pp.58~61 (2003), 한국약용작물학회
- Su Jeong Kim, "Identification for Flavones in Different Parts of Cirsium japonicum", Preventive Nutrition and Food Science, 8(4), pp.330~335 (2003), 한국식품영양과학회
- Lee, M. K., "Screening of immune enhancing activities in medicinal herbs, Compositae", Korean J Medicinal Crop Sci, 10, pp.51~57 (2002)
- Park, J. C., "Effects of methanol extract of Cirsium japonicum var. ussuriense and its principle, hispidulin-7-O-neohesperidoside on hepatic alcohol-metabolizing enzymes and lipid peroxidation in ethanol-treated rats", Phytother, 18, pp.19~24 (2004)
- 목지예, "엉겅퀴(Cirsium japonicum var. ussuriense) 부위별 추출물의 항산화 및 항염증 효과", 대한본초학회지, 26(4), pp.39~47 (2011), 대한본초학회
- 강현주, "엉겅퀴(Cirsium japonicum var. ussuriense) 잎 및 꽃 추출물이 정상인 적혈구와 혈장의 산화적 손상에 대한 보호효과", 생약학회지, 43(1), pp.66~71 (2012), 한국생약학회
- Lipsky, P.E., "Rheumatoid arthritis, In Harrisons's principles of internal medicine", pp.1968~1977 (2005), Mc Graw Hill
- Lee, J.S., "Updated on rheumatoid arthritis", Kor J Medicine, 6(3), pp.296~299 (2009)
- Iwashina, T., "Foliar flavonoid composition in Japanese Cirsium species(Compositae), and their chemotaxonomic significance", J. Japanese Bot, 70, pp.280~290 (1995)
- Kaneta, M., "Identification of flavones in sixteen Compositae species", Agric Biol Chem, 42(2), pp.475~477 (1978)
- Myers, L. K., "Characterization of recombinant type Ⅱ collagen: arthritogenicity and tolerogenicity in DBA", 1 mice, 1998, pp.95, 631~639
- Blanco, J. C., "Interferon regulatory factor (IRF)-1 and IRF-2 regulate interferon gamma-dependent cyclooxygenase 2 expression", J. Exp. Med, 191(12), pp.2131~2144 (2000)