양춘사 추출물이 HepG2 세포에서 콜레스테롤 합성에 미치는 효과
Effects of Amomum Villosum Extracts on Cholesterol Synthesis in HepG2 Cells
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초록
Dried fruits of Amomum villosum Lour. have been used an korean medicine to treat digestive diseases for a long time. It has been reported that Amomum villosum extracts(AVE) have effects for diabetes and steatosis in experimental models. But we did not find the report about the cholesterol synthesis inhibition effects of AVE. The objective of this study is to clarify the inhibitory effect of AVE against oleic acid and glucose-induced hypercholesterolemia in HepG2 cells. The results show that AVE had a significant inhibitory effect against oleic acid and glucose-induced cholesterol accumulation. Those effects seem to be caused by inhibition of AVE on oleic acid and glucose-induced decrease of HMG CoA reductase, which is the rate-limiting enzyme for cholesterol biosynthesis in liver. It is believed that the results of this study can provide basic data for the drug and functional food development of hypercholesterolemia treatments.
Abstract
Dried fruits of Amomum villosum Lour. have been used an korean medicine to treat digestive diseases for a long time. It has been reported that Amomum villosum extracts(AVE) have effects for diabetes and steatosis in experimental models. But we did not find the report about the cholesterol synthesis inhibition effects of AVE. The objective of this study is to clarify the inhibitory effect of AVE against oleic acid and glucose-induced hypercholesterolemia in HepG2 cells. The results show that AVE had a significant inhibitory effect against oleic acid and glucose-induced cholesterol accumulation. Those effects seem to be caused by inhibition of AVE on oleic acid and glucose-induced decrease of HMG CoA reductase, which is the rate-limiting enzyme for cholesterol biosynthesis in liver. It is believed that the results of this study can provide basic data for the drug and functional food development of hypercholesterolemia treatments.
참고문헌 (26)
- Jameson JL, "Harrison's Principles of Internal Medicine", pp.2889~2891 (2018), McGraw-Hill Education
- Goldman Lee, "Goldman-Cecil Medicine", pp.1389~1397 (2016), Elsevier Saunders
- Korea Health Statistics 2018: Korea National Health and Nutrition Examination Survey (KNHANES Ⅶ-3), "Korea Centers for Disease Control and Prevention", 26~27 (2019)
- Seon IC, "Drug research and development tend to hyperlipidemia", Journal of Hawhwa Medicine, 18(2), pp.1~12 (2009)
- Hong YK, "Review of Korean Medical Treatment in Hyperlipidemia - Focusing on Treatment of Korean Herbal Medicine", Korean J. Oriental Physiology & Pathology, 24(1), pp.9~14 (2010)
- Herbology Editorial Committee of Korean Medicine., "Herbology", pp.331~332 (2020), Younglinsa
- Pharmacology Editorial Committee of Korean Medicine, "Korean Pharmacology", pp.749~750 (2015), Shinil Books
- Sizhuo Suo, "Phytochemicals, pharmacology, clinical application, patents, and products of Amomi fructus", Food and Chemical Toxicology, 119, pp.31~36 (2018)
- Choi BY, "Effects of Amomum villosum (AMV) Extract on the Alzheimer's Disease Model", Korean J. Oriental Physiology & Pathology, 20(1), pp.43~51 (2006)
- Lee JH, "Study on the Antidiabetic Effect of Amomum xanthioides Extract", Korean J. Oriental Physiology & Pathology, 21(2), pp.468~473 (2007)
- Rho HW, "Therapeutic Effect of Amomum xanthoides Extract on Experimental Diabetes Induced by Alloxan", Diabetes and Metabolism journal, 26(2), pp.126~133 (2002)
- Park BH, "The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NF-κB activation", Experimental and Molecular Medicine, 33(2), pp.64~68 (2001)
- Kim HR, "Inhibitory effect of Amomum villosum water extracts on α-glucosidase activity", Physiological and Molecular Plant Pathology, 117, pp.101779~ (2022)
- Shanhong Lu, "Volatile Oil of Amomum villosum Inhibits Nonalcoholic Fatty Liver Disease via the Gut-Liver Axis", BioMed Research International, 3589874, pp.16~ (2018)
- Wang JH, "An herbal fruit, Amomum xanthoides, ameliorates thioacetamide-induced hepatic fibrosis in rat via antioxidative system", Journal of Ethnopharmacology, 135(2), pp.344~394 (2011)
- Lee SH, "Amomum villosum induces longitudinal bone growth in adolescent female rats", Journal of Traditional Chinese Medicine, 32(3), pp.453~458 (2012)
- Kim HR, "Amomum villosum Lour. fruit extract ameliorates high-fat diet-induced body mass gain and adipogenic pathways in C57BL", 6 mice, 2021, pp.33, 101473~
- Champe PC, "Lippincott's Illustrated Reviews: Biochemistry", pp.219~237 (2008), LWW
- Harvey RA, "Lippincott's Illustrated Review:Pharmacology", pp.265~275 (2012), Shinil books
- Edmunds MW, "Introduction to Clinical Pharmacology", pp.213~218 (2018), Hyunmoonsa
- Kim YS, "Amomum villosum Lour. Fruit extract mitigates hyperlipidemia through SREBP-2", LDLR, Journal of King Saud University – Science, pp.2022, 24[DOI]
- Choi HJ, "Management of Risk of Statin Therapy", Korean Journal of Family Medicine, 25(10), pp.713~720 (2004)
- Ahmadizar F, "Associations of statin use with glycaemic traits and incident type 2 diabetes", Br J Clin Pharmacol, 85, pp.993~1002 (2019)
- Choi SH, "Study for Trends of Antihyperlipidemic Studies using Herbal Plants", Korea j. Orient. Int. Med, 31(3), pp.448~456 (2010)
- Lee SK, "Effect of CRATAEGII FRUCTUS on Sarum Lipid in High Cholesterol Diet Induced Hyperlipide Rats", Journal of Society of Preventive Korean Medicine, 7(2), pp.13~22 (2003)
- Kim HC, "Effects of Salviae miltiorrhizae Radix(SMR) on Serum Lipid Level in Hyperlipidemic Rats", Kor. J. Herbology, 22(4), pp.239~245 (2007)