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Pitfalls in the Interpretation of Publications about Endoscopic Submucosal Dissection of Early Gastric Cancer with Undifferentiated-Type Histology

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초록

Endoscopic submucosal dissection (ESD) is a standard treatment for patients with gastrointestinal neoplasms with a negligible risk oflymph node metastasis. ESD enables en bloc resection of gastrointestinal neoplasms and organ preservation, thereby, avoiding surgicaltreatment. Although small (<2 cm) intramucosal early gastric cancer with undifferentiated-type histology (EGC-UH) without ulcerationis included in the expanded criteria for ESD, controversies remain due to different biology and characteristics compared to EGC withdifferentiated-type histology. The authors previously presented studies about the technical feasibility of ESD for these lesions using ameta-analysis and retrospective multicenter analysis. However, many pitfalls were identified in the interpretation of studies analyzinghistologic discrepancy, mixed-type histology, criteria-based analysis of therapeutic outcomes, interpretation of curative resection, andlong-term clinical outcomes. In this review, the authors discuss pitfalls in the interpretation of publications on ESD for EGC-UH.

Abstract

Endoscopic submucosal dissection (ESD) is a standard treatment for patients with gastrointestinal neoplasms with a negligible risk oflymph node metastasis. ESD enables en bloc resection of gastrointestinal neoplasms and organ preservation, thereby, avoiding surgicaltreatment. Although small (<2 cm) intramucosal early gastric cancer with undifferentiated-type histology (EGC-UH) without ulcerationis included in the expanded criteria for ESD, controversies remain due to different biology and characteristics compared to EGC withdifferentiated-type histology. The authors previously presented studies about the technical feasibility of ESD for these lesions using ameta-analysis and retrospective multicenter analysis. However, many pitfalls were identified in the interpretation of studies analyzinghistologic discrepancy, mixed-type histology, criteria-based analysis of therapeutic outcomes, interpretation of curative resection, andlong-term clinical outcomes. In this review, the authors discuss pitfalls in the interpretation of publications on ESD for EGC-UH.

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관련 논문AI추천

Strategy for Curative Endoscopic Resection of Undifferentiated-Type Early Gastric CancerJie-Hyun Kim대한소화기내시경학회 · Clinical Endoscopy2019 · 제52권 제1호Endoscopic Submucosal Dissection versus Surgery for Undifferentiated-Type Early Gastric Cancer: A Systematic Review and Meta-AnalysisByung-Wook Kim, Cheal-Wung Huh, Dae Won Ma, Joon Sung Kim, Seung Jae Lee대한소화기내시경학회 · Clinical Endoscopy2021 · 제54권 제2호Outcomes of Endoscopic Submucosal Dissection for Early Gastric Cancer with Undifferentiated-Type Histology: A Clinical Simulation Using a Non- Selected Surgical CohortByung-Hoon Min, Dong Shin Kwak, Hyuk Lee, Jae J. Kim, Jun Haeng Lee, Kyoung-Mee Kim, Seung Hyeon Jang, Soo Hoon Kang, Sung Kim, Tae Sung Sohn, Yang Won Min거트앤리버 소화기연관학회협의회 · Gut and Liver2018 · 제12권 제3호Therapeutic Outcomes of Endoscopic Resection of Early Gastric Cancer with Undifferentiated-Type Histology: A Korean ESD Registry Database Analysis박재명, 박종재, 방창석, 백광호, 성재규, 장재영, 전성우, 조광범, 주문경, 최석채대한소화기내시경학회 · Clinical Endoscopy2017 · 제50권 제6호Clinical Outcomes of Endoscopic Submucosal Dissection for Undifferentiated or Submucosal Invasive Early Gastric Cancer이병석, 정현용, Eaum Seok Lee, Eui-Sik Kim, Hee Seok Moon, Hye Jin Kim, Hyuk Soo Eun, Jae Kyu Sung, Min Jung Kim, Pyung Gohn Goh, Seok Hyun Kim, Soo Youn Lee, Yun Jeung Kim대한소화기내시경학회 · Clinical Endoscopy2011 · 제44권 제2호Long-Term Outcome of Extended Endoscopic Submucosal Dissection for Early Gastric Cancer with Differentiated Histology안지영, 정훤영대한소화기내시경학회 · Clinical Endoscopy2013 · 제46권 제5호

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