Fecal Microbiota Transplantation: Is It Safe?
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally considered safe and well-tolerated - even in high-risk patients. Most short-term risks are mild and known to beassociated with delivery methods. Long-term side effects have not been established, and no signs of harm have been found to date. However, causality for several microbiome-associated diseases has to be established. Even though FMT is generally considered safewith strict donor screening, serious adverse events have been recently associated with the FMT product from the stool bank, wherescreening for multi-drug resistant organisms is not included in protocols. Here, we discuss the adverse events associated with FMTand safety issues.
Abstract
Fecal microbiota transplantation (FMT) is an accepted procedure for the management of recurrent Clostridioides difficile infections. FMT is generally considered safe and well-tolerated - even in high-risk patients. Most short-term risks are mild and known to beassociated with delivery methods. Long-term side effects have not been established, and no signs of harm have been found to date. However, causality for several microbiome-associated diseases has to be established. Even though FMT is generally considered safewith strict donor screening, serious adverse events have been recently associated with the FMT product from the stool bank, wherescreening for multi-drug resistant organisms is not included in protocols. Here, we discuss the adverse events associated with FMTand safety issues.
참고문헌 (22)
- Wang S, "Systematic review : adverse events of fecal microbiota transplantation", PLoS One, 11, pp.e0161174~ (2016)
- DeFilipp Z, "Drug-resistant E. coli bacteremia transmitted by fecal microbiota transplant", N Engl J Med, 381, pp.2043~2050 (2019)
- Merrick B, "Regulation, risk and safety of faecal microbiota transplant", Infection Prevention in Practice, 2, pp.100069~ (2020)
- Kelly CR, "Fecal microbiota transplantation is highly effective in real-world practice : initial results from the fmt national registry", Gastroenterology, 160, pp.183~192 (2021)
- Bonovas S, "Systematic review with meta-analysis : use of 5-aminosalicylates and risk of colorectal neoplasia in patients with inflammatory bowel disease", Aliment Pharmacol Ther, 45, pp.1179~1192 (2017)
- Baxter M, "Fatal aspiration pneumonia as a complication of fecal microbiota transplant", Clin Infect Dis, 61, pp.136~137 (2015)
- Furuya-Kanamori L, "Upper versus lower gastrointestinal delivery for transplantation of fecal microbiota in recurrent or refractory Clostridium difficile infection : a collaborative analysis of individual patient data from 14 studies", J Clin Gastroenterol, 51, pp.145~150 (2017)
- Gulati M, "Delivery routes for faecal microbiota transplants : available, anticipated and aspired", Pharmacol Res, 159, pp.104954~ (2020)
- Smillie CS, "Strain tracking reveals the determinants of bacterial engraftment in the human gut following fecal microbiota transplantation", Cell Host Microbe, 23, pp.229~240 (2018)
- Moayyedi P, "Fecal microbiota transplantation induces remission in patients with active ulcerative colitis in a randomized controlled trial", Gastroenterology, 149, pp.102~109 (2015)
- Paramsothy S, "Multidonor intensive faecal microbiota transplantation for active ulcerative colitis : a randomised placebo-controlled trial", Lancet, 389, pp.1218~1228 (2017)
- Brandt LJ, "Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection", Am J Gastroenterol, 107, pp.1079~1087 (2012)
- Shogbesan O, "A systematic review of the efficacy and safety of fecal microbiota transplant for Clostridium difficile infection in immunocompromised patients", Can J Gastroenterol Hepatol, 2018, pp.1394379~ (2018)
- Alrabaa S, "Fecal microbiota transplantation outcomes in immunocompetent and immunocompromised patients : a single-center experience", Transpl Infect Dis, 19 (2017)
- Lin SC, "Fecal microbiota transplantation for recurrent Clostridium difficile infection in patients with solid organ transplants : an institutional experience and review of the literature", Transpl Infect Dis, 20, pp.e12967~ (2018)
- Mullish BH, "The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications : joint British Society of Gastroenterology(BSG)and Healthcare Infection Society(HIS)guidelines", Gut, 67, pp.1920~1941 (2018)
- Luo Y, "Fecal microbiota transplantation for Clostridioides difficile in high-risk older adults is associated with early recurrence", Dig Dis Sci, 65, pp.3647~3651 (2020)
- Imdad A, "Fecal transplantation for treatment of inflammatory bowel disease", Cochrane Database Syst Rev, 11, pp.CD012774~ (2018)
- Cheng Y-W, "Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients : a multicenter experience", Am J Transplant, 19, pp.501~511 (2019)
- Caldeira L de F, "Fecal microbiota transplantation in inflammatory bowel disease patients : a systematic review and meta-analysis", PLoS One, 15, pp.e0238910~ (2020)
- Ianiro G, "Reorganisation of faecal microbiota transplant services during the COVID-19 pandemic", Gut, 69, pp.1555~1563 (2020)
- Ianiro G, "Maintaining standard volumes, efficacy and safety, of fecal microbiota transplantation for C. difficile infection during the COVID-19 pandemic : a prospective cohort study", Dig Liver Dis, 52, pp.1390~1395 (2020)