전신 질환 및 경구 철분 제재와 연관된 십이지장 가성흑색증 2예
Two Cases of Pseudomelanosis Duodeni Associated with Systemic Diseases and Oral Iron Supplementation
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초록
십이지장 가성흑색증은 십이지장 점막에 미만성의 작은 흑갈색 반점을 특징으로 병리조직학 검사에서 십이지장 점막 고유판에 헤모시데린 색소 침착으로 발현되는 드문 양성 질환이다. 이 질환은 대부분 무증상으로 내시경 검사에서 우연히 발견되며 가역적으로 색소 침착이 소실될 수도 있다. 다양한 전신 질환 및 약제들과 연관성이 알려져 있지만, 색소 침착의 원인과 자연경과에 대해서는 아직 명백하게 설명되지 못하고 있다. 저자들은 당뇨병, 고혈압, 만성 신부전으로 항고혈압 제재와 경구 철분 제재를 복용 중인 환자들에서 발생한 십이지장 가성흑색증 두 증례를 경험하여 문헌고찰과 함께 국내에 보고된 증례들의 특징을 분석해 보고한다.
Abstract
Pseudomelanosis duodeni is a rare benign condition that manifests endoscopically as diffuse, small brownish-black spots in the duodenal mucosa, and the histochemical findings show an accumulation of hemosiderin pigment in the duodenal villi’s lamina propria. This condition produces no specific symptoms, and it may be reversible. The cause and natural history of the pigmentation have not been clarified, although it is associated with a variety of systemic illnesses and medications. We describe two cases of pseudomelanosis duodeni and the patients had histories of diabetes mellitus, hypertension, chronic renal insufficiency and specific medications. We also review the relevant medical literature on this rare condition.
참고문헌 (17)
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