본태성 혈소판증가증에서 동반된 양측 대뇌 피질성 뇌병증

Abstract

Background : Cerebral infarction is associated with a number of hypercoaguable hematologic disorders. Essential thrombocytosis is characterized by a markedly elevated platelet count with microvascular thromboses and can cause a variety of neurologic disorders including stroke. Case Report : We experienced a patient with neurologic symptom of bilateral weakness in upper limbs. Brain MRI showed unique feature of ischemic changes in the cerebral cortex of bilateral hemisphere. There were no identifiable stroke etiologies except severe thrombocytosis. Peripheral blood smear and bone marrow biopsy revealed essential thrombocytosis. Neurologic symptoms and signal changes in brain MRI were improved without recurrent thrombotic event after treatment with aspirin and hydroxyurea. Conclusion : Bilateral cerebral infarction may develop in a patient with essential thrombocytosis. Neurologic symptoms and MRI findings may improve with aspirin and hydroxyurea. Korean Journal of Stroke 2001;3(1): 106~110