급성기 뇌경색환자의 내원시 Troponin-I 수치와 예후와의 연관성

Abstract

Background : Ischemic stroke and coronary artery disease share the similar pathologic mechanisms. Troponin-I is a specific marker for ischemic heart injury. Previous studies suggested that Troponin-I could predict the clinical outcome of ischemic stroke. In this study, we investigated the clinical significance and prognostic value of plasma level of Troponin-I in patients with acute ischemic stroke. Methods : Eighty-five patients with acute ischemic stroke were included in this study. Plasma Troponin-I level was measured within 24 hrs after stroke onset. We evaluated the clinical characteristics and outcome of the patients wiin acute ischemic stroke with the increased plasma concentration of Troponin-I. Results : Fourteen patient had Troponin-I values at 0.5mg/L or higher, indicating the presence of myocardial injury. Among the 14 patients, 7 patients had large artery atherosclerotic infarction (50%), 2 patients cardioembolism (14%), 4 patients undetermined type (29%) and 1 patient had small vessel disease (7%). Patients with detectable Troponin-I level more often had abnormal values of C-reactive protein and lower functional and neurological scores at admission than those without. Also, patients with increased Troponin-I level had a tendency for poor clinical outcome. Conclusions : These results suggest that the increased level of Troponin-I in patients with acute ischemic stroke may predict the poor outcome.