마크로글로불린혈증을 동반한 림프절 변연부 B세포 림프종 1예
A case of nodal marginal zone B-cell lymphoma with macroglobulinemia
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초록
저자들은 임상적, 조직학적, 면역학적으로 확인된 단클론성 감마글로불린혈증(IgM, Kappa)이 아직까지 별로 알려지지 않은 림프절 변연부 B세포 림프종에서도 동반된 예를 경험하였으며, 앞으로 더 많은 예에서 다른 이상이 발견될 것으로 기대된다.
Abstract
Macroglobulinemia is the result of an uncontrolled proliferation of lymphocytes and plasma cells in which a large IgM M protein is produced. IgM monoclonal gammopathy is recognized in a variety of lymphoproliferative diseases and Waldenström's macroglobulinemia (WM) is the most frequent disease in this group. We report a case of nodal marginal zone B-cell lymphoma (Nodal MZBCL) accompanied by monoclonal macroglobulinemia. A 58-year-old man was admitted to the hospital with chronic fatigue and dyspnea. Physical examination revealed cervical, subaxillary, and inguinal lymphadenopathy. Histopathologically, monocytoid B cells with abundant pale cytoplasm and small nuclei infiltrated the cervical lymph node. The neoplastic cells were positive for CD 20, bcl-2, and IgM. The serum and urine electrophoresis showed monoclonal spike in the globulin region and immunoelectrophoresis demonstrated immunoglobulin of IgM, kappa type. Immunohistochemically, this monoclonal gammaglobulinemia (IgM, Kappa) was produced and secreted from the nodal MZBCL. This is the first report of nodal MZBCL accompanying macroglobulinemia in Korea.
참고문헌 (12)
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