원발성 식도 T 세포 악성림프종 1예
A case of primary esophageal T-cell malignant lymphoma
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초록
위장관에 발생하는 T세포 악성림프종은 발생 빈도가 낮고, 특히 식도에 발생하는 원발성 T세포 악성림프종은 극히 드문 것으로 보고되고 있다. 저자들은 60세 남자로 수 주 간의 연하곤란을 주소로 내원하여 상부위장관 내시경 검사 및 방사선학적 검사상 T세포 악성림프종으로 진단받은 후 복합항암요법을 통해 성공적으로 치료된 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Abstract
Gastrointestinal tract (GIT) lymphomas usually originate from B-lymphocytes but rarely from T-lymphocytes. The stomach is the most common site for extranodal GIT lymphoma but the esophagus is a rare site. In addition, a primary esophageal T-cell lymphoma is an uncommon disorder. We encountered a case of a primary esophageal T-cell lymphoma in a 60-year-old man, who had swallowing difficulties and multiple ulcers in the upper and lower esophageal mucosa on gastroscopy. Immunohistochemical staining for the biopsy material from the multiple esophageal ulcers tested positive for LCA and CD45RO (pan T-cell marker) and negative for cytokeratin and CD20 reactivity, respectively. No other abnormal lesions were observed on a computed tomography scan of the neck, chest, abdomen and pelvis. After six cycles of combination chemotherapy with cyclophosphamide, adriamycin, vincristin, prednisolone, etoposide and gemcitabine, the multiple esophageal ulcers had completely disappeared suggesting a complete clinical response. We report this case with a review of the relevant literature(Korean J Med 71:694-698, 2006)
참고문헌 (9)
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