Early Life Body Size in Relation to First Intracerebral or Subarachnoid Hemorrhage
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Purpose As risk of hemorrhagic stroke may have early life origins, we investigated associations of birth weight and childhood body mass index (BMI) with adult intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH). Methods We included 240,234 Danish schoolchildren, born 1936 to 1989, with information on birth weight and measured weights and heights from 7 to 13 years. We calculated hazard ratios (HRs) and confidence intervals (CIs) for the associations between early life anthropometrics and ICH or SAH, identified through linkage with national registers. Results During the study period, 1,947 individuals (39% women) experienced an ICH and 797 individuals (64% women) experienced a SAH. Per 500 g increase in birth weight, women had a 10% decreased risk of SAH (HR, 0.90; 95% CI, 0.83 to 0.97) and men had a 10% decreased risk of ICH (HR, 0.90; 95% CI, 0.85 to 0.95). Birth weight was not associated with risks of ICH in women or SAH in men. In men, a childhood BMI below average (BMI z-score <0) was associated with increased risks of ICH. The association was stronger at older childhood ages, and at 13 years a BMI z-score of –1 was associated with a HR of 1.17 (95% CI, 1.06 to 1.28), and a BMI z-score of –2 with a HR of 1.46 (95% CI, 1.17 to 1.82) for ICH. Childhood BMI was not associated with risks of ICH in women or with risks of SAH in both sexes. Conclusions Early life body size is associated with ICH and SAH, and the associations differ by sex.
Abstract
Background and Purpose As risk of hemorrhagic stroke may have early life origins, we investigated associations of birth weight and childhood body mass index (BMI) with adult intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH). Methods We included 240,234 Danish schoolchildren, born 1936 to 1989, with information on birth weight and measured weights and heights from 7 to 13 years. We calculated hazard ratios (HRs) and confidence intervals (CIs) for the associations between early life anthropometrics and ICH or SAH, identified through linkage with national registers. Results During the study period, 1,947 individuals (39% women) experienced an ICH and 797 individuals (64% women) experienced a SAH. Per 500 g increase in birth weight, women had a 10% decreased risk of SAH (HR, 0.90; 95% CI, 0.83 to 0.97) and men had a 10% decreased risk of ICH (HR, 0.90; 95% CI, 0.85 to 0.95). Birth weight was not associated with risks of ICH in women or SAH in men. In men, a childhood BMI below average (BMI z-score <0) was associated with increased risks of ICH. The association was stronger at older childhood ages, and at 13 years a BMI z-score of –1 was associated with a HR of 1.17 (95% CI, 1.06 to 1.28), and a BMI z-score of –2 with a HR of 1.46 (95% CI, 1.17 to 1.82) for ICH. Childhood BMI was not associated with risks of ICH in women or with risks of SAH in both sexes. Conclusions Early life body size is associated with ICH and SAH, and the associations differ by sex.
참고문헌 (30)
- Krishnamurthi RV, "Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010", Lancet Glob Health, 1, pp.e259~e281 (2013)
- Feigin VL, "Global burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013", Lancet Neurol, 15, pp.913~924 (2016)
- Donnan GA, "Stroke", Lancet, 371, pp.1612~1623 (2008)
- Qureshi AI, "Intracerebral haemorrhage", Lancet, 373, pp.1632~1644 (2009)
- Meschia JF, "Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association", American Stroke Association, 2014, pp.45, 3754~3832
- Lawlor DA, "Association of body mass index measured in childhood, adolescence, and young adulthood with risk of ischemic heart disease and stroke: findings from 3 historical cohort studies", Am J Clin Nutr, 83, pp.767~773 (2006)
- Lawlor DA, "Association of body mass index and obesity measured in early childhood with risk of coronary heart disease and stroke in middle age: findings from the aberdeen children of the 1950s prospective cohort study", Circulation, 111, pp.1891~1896 (2005)
- Eriksson JG, "Early growth, adult income, and risk of stroke", Stroke, 31, pp.869~874 (2000)
- Osmond C, "Infant growth and stroke in adult life: the Helsinki birth cohort study", Stroke, 38, pp.264~270 (2007)
- Ohlsson C, "BMI increase through puberty and adolescence is associated with risk of adult stroke", Neurology, 89, pp.363~369 (2017)
- Gjærde LK, "Association of childhood body mass index and change in body mass index with first adult ischemic stroke", JAMA Neurol, 74, pp.1312~1318 (2017)
- Baker JL, "Cohort profile: the Copenhagen School Health Records Register", Int J Epidemiol, 38, pp.656~662 (2009)
- Andersen TF, "The Danish National Hospital Register: a valuable source of data for modern health sciences", Dan Med Bull, 46, pp.263~268 (1999)
- Juel K, "The Danish registers of causes of death", Dan Med Bull, 46, pp.354~357 (1999)
- Cole TJ, "Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity", Pediatr Obes, 7, pp.284~294 (2012)
- Rich-Edwards JW, "Longitudinal study of birth weight and adult body mass index in predicting risk of coronary heart disease and stroke in women", BMJ, 330, pp.1115~ (2005)
- Hyppönen E, "Prenatal growth and risk of occlusive and haemorrhagic stroke in Swedish men and women born 1915-29: historical cohort study", BMJ, 323, pp.1033~1034 (2001)
- Lawlor DA, "Birth weight is inversely associated with incident coronary heart disease and stroke among individuals born in the 1950s: findings from the Aberdeen Children of the 1950s prospective cohort study", Circulation, 112, pp.1414~1418 (2005)
- Heshmati A, "Maternal pelvic size, fetal growth and risk of stroke in adult offspring in a large Swedish cohort", J Dev Orig Health Dis, 7, pp.108~113 (2016)
- Martyn CN, "Mothers’ pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK", Lancet, 348, pp.1264~1268 (1996)
- Gamborg M, "Birth weight and systolic blood pressure in adolescence and adulthood: meta-regression analysis of sex- and age-specific results from 20 Nordic studies", Am J Epidemiol, 166, pp.634~645 (2007)
- Yoon SS, "Trends in blood pressure among adults with hypertension: United States, 2003 to 2012", Hypertension, 65, pp.54~61 (2015)
- 김태종, "Trends in Blood Pressure and Prevalence of Hypertension in Korean Adults Based on the 1998–2014 KNHANES", Yonsei Medical Journal, 59(3), pp.356~365 (2018), 연세대학교의과대학[DOI]
- Gamborg M, "Life course path analysis of birth weight, childhood growth, and adult systolic blood pressure", Am J Epidemiol, 169, pp.1167~1178 (2009)
- Baker JL, "Childhood body-mass index and the risk of coronary heart disease in adulthood", N Engl J Med, 357, pp.2329~2337 (2007)
- Biffi A, "Body mass index and etiology of intracerebral hemorrhage", Stroke, 42, pp.2526~2530 (2011)
- Lindekleiv H, "Sex differences in risk factors for aneurysmal subarachnoid hemorrhage: a cohort study", Neurology, 76, pp.637~643 (2011)
- Gjærde LK, "Childhood stature and growth in relation to first ischemic stroke or intracerebral hemorrhage", Stroke, 49, pp.579~585 (2018)
- Jensen CB, "Comparison of birth weight between school health records and medical birth records in Denmark: determinants of discrepancies", BMJ Open, 5, pp.e008628~ (2015)
- Galobardes B, "Systematic review of the influence of childhood socioeconomic circumstances on risk for cardiovascular disease in adulthood", Ann Epidemiol, 16, pp.91~104 (2006)