춘천 지역의 위식도 역류질환과 역류성 식도염의 특징 -건강 검진자 연구
Prevalence and clinical characteristics of gastroesophageal reflux disease and reflux esophagitis in chuncheon city-Health care examination study
2
조회
0
다운로드
8
인용
0
참고문헌
키워드
초록
Background/Aims : The aims of this study were to estimate the frequency of symptoms of gastroesophageal reflux disease and reflux esophagitis, to evaluate the difference in characteristics among groups subdivided by symptoms, and to compare clinical features between a reflux esophagitis group and a non‐reflux esophagitis group in Chuncheon City. Methods : A total of 1,011 persons who underwent endoscopy for health check‐up were enrolled between July 1, 2005, and June 30, 2006. All persons were given a validated, self‐reported questionnaire, which inquired about the presence, frequency, and severity of typical symptoms (heartburn and acid regurgitation) and atypical symptoms. The questionnaire also inquired about smoking, alcohol intake, and Helicobacter pyroli eradication. The subjects were subdivided into typical symptomatic, atypical symptomatic, no discomfort, and asymptomatic groups. Results : The prevalence of heartburn and acid regurgitation occurring at least weekly was 7.5%. Reflux esophagitis, hiatal hernia, smoking, and alcohol intake were more common in males (p<0.05). Ninety‐eight cases (9.7%) were endoscopically diagnosed as reflux esophagitis, and sixty‐nine cases (6.8%) were endoscopically suspected esophageal metaplasia (ESEM). Subjects in the symptomatic group more frequently manifested reflux esophagitis than subjects in the asymptomatic group (p<0.05). Conclusions : The presence of reflux‐induced symptoms is related to reflux esophagitis, but the intensity and frequency of symptoms are poor predictors of the presence or severity of endoscopic mucosal breaks. (Korean J Med 74:385-390, 2008)
Abstract
Background/Aims : The aims of this study were to estimate the frequency of symptoms of gastroesophageal reflux disease and reflux esophagitis, to evaluate the difference in characteristics among groups subdivided by symptoms, and to compare clinical features between a reflux esophagitis group and a non‐reflux esophagitis group in Chuncheon City. Methods : A total of 1,011 persons who underwent endoscopy for health check‐up were enrolled between July 1, 2005, and June 30, 2006. All persons were given a validated, self‐reported questionnaire, which inquired about the presence, frequency, and severity of typical symptoms (heartburn and acid regurgitation) and atypical symptoms. The questionnaire also inquired about smoking, alcohol intake, and Helicobacter pyroli eradication. The subjects were subdivided into typical symptomatic, atypical symptomatic, no discomfort, and asymptomatic groups. Results : The prevalence of heartburn and acid regurgitation occurring at least weekly was 7.5%. Reflux esophagitis, hiatal hernia, smoking, and alcohol intake were more common in males (p<0.05). Ninety‐eight cases (9.7%) were endoscopically diagnosed as reflux esophagitis, and sixty‐nine cases (6.8%) were endoscopically suspected esophageal metaplasia (ESEM). Subjects in the symptomatic group more frequently manifested reflux esophagitis than subjects in the asymptomatic group (p<0.05). Conclusions : The presence of reflux‐induced symptoms is related to reflux esophagitis, but the intensity and frequency of symptoms are poor predictors of the presence or severity of endoscopic mucosal breaks. (Korean J Med 74:385-390, 2008)
참고문헌 (17)
- Howard PJ, "Symptomatic gastro-esophageal reflux, abnormal esophageal acid exposure, and mucosal acid sensitivity and three separate, through related, aspects gastroesophageal reflux disease", Gut, 32, pp.128~132 (1991)
- "An evidence-based appraisal of reflux disease management: the Genval Workshop report", Gut, 44, pp.1~16 (1999)
- Vakil N, "The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus", Am J Gastroenterol, 101, pp.1900~1920 (2006)
- Stanghellini V, "Relationship between upper gastrointestinal symptoms and lifestyle, psychosocial factors and comorbidity in the general population", Scand J Gastroenterol Suppl, 231, pp.29~37 (1999)
- Dent J, "Epidemiology of gastro-oesophageal reflux disease: a systematic reviewEpidemiology of gastro-oesophageal reflux disease: a systematic review", Gut, 54, pp.710~717 (2005)
- 전성국, "성인 건강 검진자에서 위식도역류증상의 빈도", 대한내과학회지, 58, pp.145~151 (2000)
- 윤영호, "최근 역류성 식도염의 유병률 변화: 건강 검진자군과 소화기 증상군을 대상으로", 대한소화기내시경학회지, 23, pp.144~148 (2001)
- "대한소화관운동학회지", 2001, 88~
- Talley NJ, "Identification of distinct upper and lower gastrointestinal symptom groupings in an urban population", Gut, 42, pp.690~695 (1998)
- 오정환, "역류성 식도염으로 진단된 건강 검진자의 임상상", Journal of Neurogastroenterology and Motility (JNM), 12(1), pp.12~18 (2006), 대한소화기 기능성질환∙운동학회
- Hirota WK, "Maydonovitch CL, Rholl V, Wong RK. Specialized intestinal metaplasia, dysplasia, and cancer of the esophagus and esophagogastric junction: prevalence and clinical data", Gastroenterology, 116, pp.277~285 (1999)
- Azuma N, "Prevalence of Barrett's esophagus and expression of mucin antigens detected by a panel of monoclonal antiboieds in Barrett's esophagus and esophageal adenocarcinoma in Japan", J Gastroenterol, 35, pp.583~592 (2000)
- Kim JY, "Prevalence of Barrett's esophagus in Korea", J Gastroenterol Hepatol, 20, pp.633~636 (2005)
- Ollyo JB, "The natural history, prevalence and incidence of reflux esophagitis", Gullet, 3, pp.3~11 (1993)
- Goh KL, "Gastro-oesophageal reflux disease in Asia", J Gastroenterol Hepatol, 15, pp.230~238 (2000)
- Lee SJ, "Prevalence of endoscopic reflux esophagitis among Koreans", J Gastroenterol Hepatol, 16, pp.373~376 (2001)
- 정성애, "1990년대 한국 성인에서 역류성 식도염의 유병률 변화", 대한소화관운동학회지, 7, pp.161~167 (2001)