Endoscopic Submucosal Dissection Followed by Concurrent Chemoradiotherapy in Patients with Early Esophageal Cancer with a High Risk of Lymph Node Metastasis
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Endoscopic submucosal dissection is recommended as an alternative therapy for early esophageal cancer. However, achieving curativeresection in this procedure remains controversial since precise prediction of lymph node metastasis can be diffcult. Here, we presentthe preliminary results of endoscopic submucosal dissection followed by concurrent chemoradiotherapy for early esophageal cancerwith a high risk of lymph node metastasis. From May 2006 to January 2014, six patients underwent concurrent chemoradiotherapyafter endoscopic submucosal dissection with a median follow-up period of 63 months. No complications were encountered duringconcurrent chemoradiotherapy. Although local recurrence did not occur in all patients, two patients were diagnosed with metachronouscancer. Overall, the survival rate was 100%. Thus, endoscopic submucosal dissection followed by concurrent chemoradiotherapy maybe a feasible treatment for early esophageal cancer in patients with a high risk of lymph node metastasis. Future prospective large-scalestudies are warranted to confirm our results.
Abstract
Endoscopic submucosal dissection is recommended as an alternative therapy for early esophageal cancer. However, achieving curativeresection in this procedure remains controversial since precise prediction of lymph node metastasis can be diffcult. Here, we presentthe preliminary results of endoscopic submucosal dissection followed by concurrent chemoradiotherapy for early esophageal cancerwith a high risk of lymph node metastasis. From May 2006 to January 2014, six patients underwent concurrent chemoradiotherapyafter endoscopic submucosal dissection with a median follow-up period of 63 months. No complications were encountered duringconcurrent chemoradiotherapy. Although local recurrence did not occur in all patients, two patients were diagnosed with metachronouscancer. Overall, the survival rate was 100%. Thus, endoscopic submucosal dissection followed by concurrent chemoradiotherapy maybe a feasible treatment for early esophageal cancer in patients with a high risk of lymph node metastasis. Future prospective large-scalestudies are warranted to confirm our results.
참고문헌 (9)
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