당뇨병성 신증 연구의 최신지견
Diabetic Nephropathy: New insights into the pathogenesis
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Diabetic nephropathy is the most serious complication of diabetes mellitus and the most common cause of end-stage renal disease. It can be possible to dissect the exact mechanism of development and progression of diabetic nephropathy because the new biomedical tools for studying disease have been developed. This review explores the new insights into the pathogenesis of diabetic nephropathy, focusing the newly recognized pathways which include growth factors and inflammatory cytokines.
Abstract
Diabetic nephropathy is the most serious complication of diabetes mellitus and the most common cause of end-stage renal disease. It can be possible to dissect the exact mechanism of development and progression of diabetic nephropathy because the new biomedical tools for studying disease have been developed. This review explores the new insights into the pathogenesis of diabetic nephropathy, focusing the newly recognized pathways which include growth factors and inflammatory cytokines.
참고문헌 (28)
- Breyer MD, "Mouse models of diabetic nephropathy", J Am Soc Nephrol, 16, pp.27~45 (2005)
- Wang A, "Interference with TGF-β signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria", Am J Physiol Renal Physiol, 293, pp.1657~1665 (2007)
- Wu F, "Conditional targeting in the kidney", Nephron Physiol, 107, pp.10~16 (2007)
- Utomo AR, "Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice", Nat Biotechnol, 17, pp.1091~1096 (1999)
- "Wang J.Cre/lox Mouse Breeding.Science Creative Q"[URL]
- Lee GS, "Mesangial cell culture: its role in the understanding of the pathogenesis of glomerular disease", Ann Acad Med Singapore, 24, pp.851~855 (1995)
- Jefferson JA, "Proteinuria in diabetic kidney disease: a mechanistic viewpoint", Kidney Int, 74, pp.22~36 (2008)
- 이은영, "당뇨병성 신증에서 사구체 족세포(podocyte)의 손상 기전", 당뇨병, 27(4), pp.343~351 (2003), 대한당뇨병학회
- 이은영, "신사구체 고혈압에 의한 신손상기전: 족세포 신장 (stretch)에 의한 혈관내피성장인자의 조절", 대한고혈압학회지, 12, pp.25~32 (2006)
- 이은영, "당뇨병성 신증에서 angiopoietins 유전자의 변화", The Korean Journal of Nephrology, 26(3), pp.311~319 (2007), 대한신장학회
- Satchell SC, "What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?", Diabetologia, 51, pp.714~725 (2008)
- Nitta K, "Glomerular endothelial cell culture and its application", Nippon Rinsho, 52, pp.1389~1395 (1994)
- Savage CO, "The biology of the glomerulus: endothelial cells", Kidney Int, 45, pp.314~319 (1994)
- Lee EY, "Antioxidants ameliorate the expression of vascular endothelial growth factor mediated by protein kinase C in diabetic podocytes", Nephrol Dial Transplant, 21, pp.1496~1503 (2006)
- Kreisberg JI, "Renal cell culture", J Electron Microsc Tech, 9, pp.235~263 (1988)
- Flyvbjerg A, "Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody", Diabetes, 51, pp.3090~3094 (2002)
- 이은영, "Angiotensin II receptor blocker attenuates overexpression of vascular endothelial growth factor in diabetic podocytes", Experimental and Molecular Medicine, 36(1), pp.65~70 (2004), 생화학분자생물학회
- de Vriese AS, "Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes", J Am Soc Nephrol, 12, pp.993~1000 (2001)
- 고장현, "당뇨병성 신증에서 퍼록시솜 증식 활성화 수용체 감마 촉진제, 안지오텐신Ⅱ 수용체 억제제 및 알파-리포산이 신장 혈관 내피세포 성장인자의 발현에 미치는 영향", 당뇨병, 28(5), pp.367~376 (2004), 대한당뇨병학회
- 이미영, "Beneficial Effects of Thiazolidinediones on Diabetic Nephropathy in OLETF Rats", Yonsei Medical Journal, 48(2), pp.301~307 (2007), 연세대학교의과대학
- Gröne HJ, "Expression of vascular endothelial growth factor in renal vascular disease and renal allografts", J Pathol, 177, pp.259~267 (1995)
- Shulman K, "Expression of vascular permeability factor (VPF", VEGF) is altered in many glomerular diseases, 1996, pp.7, 661~666
- Chow, FY, "Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice", Kidney Int, 69, pp.73~80 (2006)
- Gu L, "Pravastatin inhibits carboxymethyllysine-induced monocyte chemoattractant protein 1 expression in podocytes via prevention of signaling events", Nephron Exp Nephrol, 106, pp.1~10 (2007)
- Lee EY, "Podocyte-derived MCP-1 is stimulatedby TGF-β and might contribute to diabetic nephropathy", J Am Soc Nephrol, 18, pp.655~656 (2007)
- Fornoni A, "Role of inflammation in diabetic nephropathy", Curr Diabetes Rev, 4, pp.10~17 (2008)
- Navarro-González JF, "The role of inflammatory cytokines in diabetic nephropathy", J Am Soc Nephrol, 19, pp.433~442 (2008)
- 이은영, "Blockade of Oxidative Stress by Vitamin C Ameliorates Albuminuria and Renal Sclerosis in Experimental Diabetic Rats", Yonsei Medical Journal, 48(5), pp.847~855 (2007), 연세대학교의과대학
