당뇨신병증의 최신 치료
Recent Therapies for Diabetic Nephropathy
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
전 세계적으로 당뇨는 점차 늘고 있어서 20년 후에는 약6억명의 당뇨 인구가 예측되고 있다[1]. 당뇨로 인한 합병증중에서 당뇨신병증(diabetic nephropathy)은 신대체 치료(renal replacement therapy)를 받고 있는 만성 신 질환 환자의 절반에 이르는 원인 질환이다. 최근 혈당조절과 신대체 치료가편리해지면서 당뇨와 신병증 자체만으로 인한 급성 합병증으로 사망하는 환자 수는 줄고, 심혈관 질환 등의 만성 합병증은 오히려 늘고 있는 추세이다. 그 결과 당뇨와 신병증의유병 기간은 점차 늘고 있고 이는 개인적으로는 삶의 질을떨어뜨리고 국가적으로는 의료경제비용을 재난에 가까울 정도로 상승시키고 있다.
Abstract
Diabetes mellitus (DM) is a worldwide public issue that has increased the risks for cardiovascular morbidity and mortality. It is the most common cause of chronic kidney diseases, which necessitates renal replacement therapy. Diabetic nephropathy is one of the long-term complications of DM. Renal replacement therapy has reduced the acute complications of renal dysfunction and prolonged patient survival. However, quality of life should be considered from the patient’s viewpoint. Although new treatments have been developed via experimental studies, many trials failed to show beneficial effects in clinical practice in terms of long-term complications. Since there are many limitations to large clinical studies, we hope that improved approaches for individual patients will lead to new methods to increase the effectiveness of agents though big-data analysis in the future.
참고문헌 (5)
- Fernandez-Fernandez B, "Therapeutic approaches to diabetic nephropathy-beyond the RAS", Nat Rev Nephrol, 10, pp.325~346 (2014)
- Roscioni SS, "The effects of RAAS blockade on the progression of diabetic nephropathy", Nat Rev Nephrol, 10, pp.77~87 (2014)
- Fineberg D, "Diabetic nephropathy : diagnosis and treatment", Nat Rev Endocrinol, 9, pp.713~723 (2013)
- Tuttle KR, "Diabetic kidney disease : a report from an ADA Consensus Conference", Am J Kidney Dis, 64, pp.510~533 (2014)
- Gentile G, "Novel effective drugs for diabetic kidney disease? or not?", Expert Opin Emerg Drugs, 19, pp.571~601 (2014)