Effectiveness of Autologous Platelet-Rich Plasma for the Healing of Ulcers after Endoscopic Submucosal Dissection
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Background/Aims: Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was toevaluate the clinical effcacy and safety of local PRP injections after endoscopic submucosal dissection (ESD). Methods: Patients were non-randomly divided into the following two groups: (1) control group in which patients were administeredonly an intravenous proton pump inhibitor (PPI), and (2) a study group in which patients were administered an intravenous PPI and atopical PRP injection. We assessed the reduction in the ulcer area and stage of the ulcer after the procedure (24 hours, 48 hours, and 28days after endoscopic surgery). Results: We enrolled 7 study and 7 control patients. In the study group, the rate of ulcer reduction was 59% compared to 52% inthe control group (p=0.372), 28 days after ESD. There were 5 patients in the S stage and 2 patients in the H stage in the study groupcompared to no patient in the S stage and 7 patients in the H stage in the control group (p=0.05), 28 days after ESD. There were noserious complications in either group. Conclusions: The local injection of PRP is a safe and effective procedure for ulcer healing after ESD.
Abstract
Background/Aims: Platelet-rich plasma (PRP) has been used for wound healing in various medical fields. The aim of this study was toevaluate the clinical effcacy and safety of local PRP injections after endoscopic submucosal dissection (ESD). Methods: Patients were non-randomly divided into the following two groups: (1) control group in which patients were administeredonly an intravenous proton pump inhibitor (PPI), and (2) a study group in which patients were administered an intravenous PPI and atopical PRP injection. We assessed the reduction in the ulcer area and stage of the ulcer after the procedure (24 hours, 48 hours, and 28days after endoscopic surgery). Results: We enrolled 7 study and 7 control patients. In the study group, the rate of ulcer reduction was 59% compared to 52% inthe control group (p=0.372), 28 days after ESD. There were 5 patients in the S stage and 2 patients in the H stage in the study groupcompared to no patient in the S stage and 7 patients in the H stage in the control group (p=0.05), 28 days after ESD. There were noserious complications in either group. Conclusions: The local injection of PRP is a safe and effective procedure for ulcer healing after ESD.
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