Spontaneous Spinal Epidural Hematoma in a Patient on Cilostazol
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Cilostazol is a phosphodiesterase inhibitor that has been shown to have similar efficacy in stroke prevention but fewer hemorrhagic events compared with aspirin. We report a case of spontaneous spinal epidural hematoma (SSEH) in a 67-year-old woman who has been treated with cilostazol for cerebral infarction. The patient was presented with sudden neck pain and right hemiparesis. Thirteen days after the onset, she recovered completely. Even cilostazol, which is a relatively safer drug in terms of bleeding risk compared to other antiplatelet agents, may cause SSEH. Therefore, physicians should keep in mind rare, but potentially fatal, bleeding complications such as SSEH when prescribing antiplatelet agents.
Abstract
Cilostazol is a phosphodiesterase inhibitor that has been shown to have similar efficacy in stroke prevention but fewer hemorrhagic events compared with aspirin. We report a case of spontaneous spinal epidural hematoma (SSEH) in a 67-year-old woman who has been treated with cilostazol for cerebral infarction. The patient was presented with sudden neck pain and right hemiparesis. Thirteen days after the onset, she recovered completely. Even cilostazol, which is a relatively safer drug in terms of bleeding risk compared to other antiplatelet agents, may cause SSEH. Therefore, physicians should keep in mind rare, but potentially fatal, bleeding complications such as SSEH when prescribing antiplatelet agents.
참고문헌 (16)
- Duffill J, "Can spontaneous spinal epidural hematoma be managed safely without operation? A report of four cases", J Neurol Neurosurg Psychiatry, 69, pp.816~819 (2000)
- Wang CC, "Misdiagnosis of spontaneous cervical epidural hemorrhage", Eur Spine J, 18(2), pp.210~212 (2008)
- Anderson TJ, "Spontaneous resolution of cervical spinal epidural hematoma", Postgrad Med J, 65, pp.488~490 (1989)
- Jae Hoon Sung, "Clopidogrel-induced Spontaneous Spinal Epidural Hematoma", Journal of Korean Medical Science, 22(3), pp.577~579 (2007), 대한의학회
- Dimou J, "Spontaneous spinal epidural hematoma in a geriatric patient on aspirin", J Clin Neurosci, 17, pp.142~144 (2010)
- Moon HJ, "Spontaneous spinal epidural hematoma: An urgent complication of adding clopidogrel to aspirin therapy", J Neurol Sci, 285, pp.254~256 (2009)
- Kato S, "Acute cervical spinal epidural hematoma with spontaneous resolution case report", Neurol Med Chir (Tokyo), 34, pp.23~26 (1994)
- Groen RJ, "Non-operative treatment of spontaneous spinal epidural hematomas: a review of the literature and a comparison with operative cases", Acta Neurochir, 146, pp.103~110 (2004)
- Brawn LA, "Spontaneous spinal epidural hematoma with spontaneous resolution", Postgrad Med J, 62, pp.885~887 (1986)
- Adamson DC, "Spontaneous cervical epidural hematoma: case report and literature review", Surg Neurol, 62, pp.156~159 (2004)
- Yang HD, "Spontaneous resolution of spinal epidural hematoma", J Korean Neurol Assoc, 18, pp.518~520 (2000)
- Beatty RM, "Spontaneous cervical epidural hematoma. A consideration of etiology", J Neurosurg, 61, pp.143~148 (1984)
- Kim CW, "Evaluation of anti-platelet and anti-thrombotic effects of cilostazol with PFA-100® and Multiplate® whole blood aggregometer in vitro, ex vivo and FeCl3-induced thrombosis models in vivo", Thromb Res, 127, pp.565~570 (2011)
- Gotoh F, "Cilostazol stroke prevention study: a placebo-controlled doubleblind trial for secondary prevention of cerebral infarction", J Stroke Cerebrovasc Dis, 9, pp.147~157 (2000)
- Kamal AK, "Cilostazol versus aspirin for secondary prevention of vascular events after stroke of arterial origin", Stroke, 42, pp.382~384 (2011)
- Goto S, "Cilostazol: potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding", Atheroscler Suppl, 6, pp.3~11 (2005)