조혈모세포이식 후에 만성 이식편대 숙주반응과 동반된 종격동 기종 1예
A case of pneumomediastinum combined with chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation
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초록
조혈 모세포이식을 시행한 이후에 호흡기계 부작용은 다수에서 발생한다고 보고되고 있으며, 그 중에서도 만성 GVHD와 병발하는 비감염성 호흡기계 부작용에는 폐색성모세기관지염, 기질화 폐렴을 동반한 폐색성모세기관지염 등이 있다. 그 중에서 폐색성모세기관지염은 만성 GVHD와 관련이 깊고, 이들이 동시에 발생하는 경우 종격동기종과 피하기종 등의 치명적인 부작용들이 나타날 수 있다. 저자들은 조혈모세포이식 이후에 만성 GVHD와 병발하여 발생한 비감염성 호흡기계 부작용 중의 하나인 종격동기종과 피하기종의 드문 1예를 경험하였기에 보고하는 바이다.
Abstract
Pulmonary complications are very common after allogeneic stem cell transplantation and are sometimes serious. Late-onset noninfectious pulmonary complications of chronic graft-versus-host disease (GVHD) after allogeneic stem cell transplantation include bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia. Especially, bronchiolitis obliterans is correlated with GVHD. If they occur simultaneously, serious pulmonary and subcutaneous complications such as pneumomediastinum, subcutaneous emphysema, and pneumothorax can occur. We present the case of a 19-year-old man who had pneumomediastinum, subcutaneous emphysema, and pneumothorax with GVHD after allogeneic stem cell transplantation.
참고문헌 (11)
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