Seasonal Impacts on the Incidence of Esophageal Variceal Hemorrhage: A Nationwide Analysis across a Decade
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background/Aims: Seasonal variation has previously been reported in relation to the incidence of non-variceal upper gastrointestinalbleeding; however, the impact of seasonal variation on variceal bleeding is not known. Methods: We conducted a cross-sectional study using the Nationwide Inpatient Sample database from 2005 to 2014. InternationalClassification of Diseases, Clinical Modification- 9th Revision codes were used to identify patients hospitalized with a primary orsecondary diagnosis of esophageal variceal hemorrhage. The data were analyzed based on the month of hospitalization. Our primaryaim was to assess seasonal variations in variceal bleeding-related hospitalizations. The secondary aims were to assess the impact ofseasonal variation on outcomes in variceal bleeding including in-hospital mortality and healthcare resource utilization. Results: A total of 348,958 patients hospitalized with esophageal variceal bleeding were included. The highest number of hospitalizationswas reported in December (99.3/day) and the lowest was reported in June (90.8/day). In-hospital mortality was highest in January (11.5%)and lowest in June (9.8%). There was no significant difference in hospital length of stay or total hospitalization costs across all months inall years combined. Conclusions: There appears to be a seasonal variation in the incidence and mortality of variceal hemorrhage in the United States. December was the month with the highest number of daily hospitalizations while the nadir occurred in June.
Abstract
Background/Aims: Seasonal variation has previously been reported in relation to the incidence of non-variceal upper gastrointestinalbleeding; however, the impact of seasonal variation on variceal bleeding is not known. Methods: We conducted a cross-sectional study using the Nationwide Inpatient Sample database from 2005 to 2014. InternationalClassification of Diseases, Clinical Modification- 9th Revision codes were used to identify patients hospitalized with a primary orsecondary diagnosis of esophageal variceal hemorrhage. The data were analyzed based on the month of hospitalization. Our primaryaim was to assess seasonal variations in variceal bleeding-related hospitalizations. The secondary aims were to assess the impact ofseasonal variation on outcomes in variceal bleeding including in-hospital mortality and healthcare resource utilization. Results: A total of 348,958 patients hospitalized with esophageal variceal bleeding were included. The highest number of hospitalizationswas reported in December (99.3/day) and the lowest was reported in June (90.8/day). In-hospital mortality was highest in January (11.5%)and lowest in June (9.8%). There was no significant difference in hospital length of stay or total hospitalization costs across all months inall years combined. Conclusions: There appears to be a seasonal variation in the incidence and mortality of variceal hemorrhage in the United States. December was the month with the highest number of daily hospitalizations while the nadir occurred in June.
참고문헌 (25)
- Jansen PL, "Life expectancy in liver cirrhosis after the first variceal hemorrhage : how can survival be improved?", Scand J Gastroenterol Suppl, 178, pp.106~110 (1990)
- Sempokuya T, "Temporal trends of cirrhosis associated conditions", World J Hepatol, 11, pp.74~85 (2019)
- Myers RP, "Relationship between hospital volume and outcomes of esophageal variceal bleeding in the United States", Clin Gastroenterol Hepatol, 6, pp.789~798 (2008)
- Le Moine O, "Relationship between portal pressure, esophageal varices, and variceal bleeding on the basis of the stage and cause of cirrhosis", Scand J Gastroenterol, 32, pp.731~735 (1997)
- Wang F, "Different scoring systems to predict 6-week mortality in cirrhosis patients with acute variceal bleeding : a retrospective analysis of 202 patients", Scand J Gastroenterol, 53, pp.885~890 (2018)
- Abougergi MS, "The in-hospital mortality rate for upper GI hemorrhage has decreased over 2 decades in the United States : a nationwide analysis", Gastrointest Endosc, 81, pp.882~888.e1 (2015)
- Fares A, "Global patterns of seasonal variation in gastrointestinal diseases", J Postgrad Med, 59, pp.203~207 (2013)
- Ostensen H, "Seasonal periodicity of peptic ulcer disease. A prospective radiologic study", Scand J Gastroenterol, 20, pp.1281~1284 (1985)
- Sezgin O, "Effects of seasonal variations on acute upper gastrointestinal bleeding and its etiology", Turk J Gastroenterol, 18, pp.172~176 (2007)
- Stermer E, "Seasonal fluctuations in acute gastrointestinal bleeding", J Clin Gastroenterol, 20, pp.277~279 (1995)
- Jamal MM, "Declining hospitalization rate of esophageal variceal bleeding in the United States", Clin Gastroenterol Hepatol, 6, pp.689~695 (2008)
- Quan H, "Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data", Med Care, 43, pp.1130~1139 (2005)
- Southern DA, "Comparison of the Elixhauser and Charlson", Deyo methods of comorbidity measurement in administrative data, 2004, pp.42, 355~360
- Yen FS, "Seasonal variation in the incidence of peptic ulcer and esophageal variceal bleeding in Taiwan", Zhonghua Yi Xue Za Zhi(Taipei), 57, pp.22~27 (1996)
- Boulay F, "Seasonal variations in variceal bleeding mortality and hospitalization in France", Am J Gastroenterol, 96, pp.1881~1887 (2001)
- Adler J, "Perforated peptic ulcer--a seasonal disease?", Aust N Z J Surg, 54, pp.59~61 (1984)
- Mejía Cordero F, "Seasonal variation in upper gastrointestinal bleeding associated with portal hypertension", Rev Gastroenterol Peru, 26, pp.278~282 (2006)
- Budzyński P, "Seasonal variation and influence of atmospheric pressure diurnal fluctuations on occurrence of acute complications in patients with stomach and duodenal ulcer", Przegl Lek, 57, pp.611~613 (2000)
- Langman MI, "The seasonal incidence of bleeding from the upper gastrointestinal tract", Gut, 5, pp.142~144 (1964)
- Kanotra R, "Seasonal variations and trends in hospitalization for peptic ulcer disease in the United States : a 12-year analysis of the nationwide inpatient sample", Cureus, 8, pp.e854~ (2016)
- Carbonell N, "Improved survival after variceal bleeding in patients with cirrhosis over the past two decades", Hepatology, 40, pp.652~659 (2004)
- Stokkeland K, "Improved prognosis for patients hospitalized with esophageal varices in Sweden 1969-2002", Hepatology, 43, pp.500~505 (2006)
- De Lédinghen V, "Anti-inflammatory drugs and variceal bleeding : a case-control study", Gut, 44, pp.270~273 (1999)
- Ventura-Cots M, "Colder weather and fewer sunlight hours increase alcohol consumption and alcoholic cirrhosis worldwide", Hepatology, 69, pp.1916~1930 (2019)
- Cooper GS, "The accuracy of diagnosis and procedural codes for patients with upper GI hemorrhage", Gastrointest Endosc, 51(4 Pt 1), pp.423~426 (2000)