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자가면역성 담관염 4예

Four cases of autoimmune cholangitis

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초록

저자들은 전신쇠약감 등 비특이적인 증상과 간기능 이상이 있는 환자를 대상으로 임상양상, 혈청학적, 면역학적 조직학적인 검사를 통해 AMA 음성인 자가면역성 담관염으로 진단된 네 개의 증례를 경험하여 보고하는 바이다.

Abstract

Autoimmune cholangitis is a disease with clinicopathologic features of primary biliary cirrhosis without antimitochondrial antibodies and, frequently, with high antinuclear antibody titers. Alternative terms have been suggested, including antimitochondrial antibody-negative primary biliary cirrhosis, immunocholangitis, autoimmune cholangiopathy, and autoimmune hepatobiliary overlap syndrome type 1. The question of whether autoimmune cholangitis is distinct from primary biliary cirrhosis and autoimmune hepatitis or is an antimitochondrial antibody-negative variant of primary biliary cirrhosis and autoimmune hepatitis is controversial. This case report describes the clinical, immunohistochemical, and pathological findings in four patients with autoimmune cholangitis and reviews the literature.

참고문헌 (11)

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  4. Liu B, "Antimitochondrial antibody-negative primary biliary cirrhosis: a subset of primary biliary cirrhosis", Liver Int, 28, pp.233~239 (2008)
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  6. Heathcote EJ, "Management of primary biliary cirrhosis: the American Association for the Study of Liver Diseases practice guidelines", Hepatology, 31, pp.1005~1013 (2000)
  7. Invernizzi P, "Comparison of the clinical features and clinical course of antimitochondrial antibody-positive and-negative primary biliary cirrhosis", Hepatology, 25, pp.1090~1095 (1997)
  8. Kim WR, "Does antimitochondrial antibody status affect response to treatment in patients with primary biliary cirrhosis?: outcomes of ursodeoxycholic acid therapy and liver transplantation", Hepatology, 26, pp.22~26 (1997)
  9. Michieletti P, "Antimitochondrial antibody negative primary biliary cirrhosis: a distinct syndrome of autoimmune cholangitis", Gut, 35, pp.260~265 (1994)
  10. Manns MP, "Immunogenetics of chronic liver diseases", Gastroenterology, 106, pp.1676~1697 (1994)
  11. Czaja AJ, "Patterns of nuclear immunofluorescence and reactivities to recombinant nuclear antigens in autoimmune hepatitis", Gastroenterology, 107, pp.200~207 (1994)

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