건강 검진 시 혈청 CA 19-9 증가로 발견된 갑상선유두암 1예
A Case Report of Papillary Thyroid Carcinoma Presenting as Elevated Serum CA 19-9
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초록
본 증례는 수술 전 증가되었던 혈청 CA 19-9 농도가 갑상선전절제술 후 정상화되었고, 갑상선내 다른 병리 소견이 없어서 갑상선유두암 조직이 CA 19-9 분비의 원인이었음을 알 수 있는 증례이다. 이는 혈청 CA 19-9 증가의 원인으로서 밝혀진 갑상선유두암의 국내 첫 증례 보고이며, 췌장 담도 질환이 동반되지 않은 환자에서 혈청 CA 19-9 증가가 있다면 갑상선암의 가능성도 고려해야 함을 시사한다.
Abstract
A 47-year-old man had elevated serum CA 19-9 after a routine health check-up. He had normal CA 19-9 levels during the preceding 8 years on annual heath checks. Imaging studies for pancreatic or biliary tract diseases revealed no abnormalities. A huge hypermetablic lesion was found in the right lobe of the thyroid on 18F-fluorodeoxyglucose positron emission tomography/computed tomography. We performed a fine needle aspiration of the thyroid nodule. He was diagnosed with papillary thyroid carcinoma and underwent a total thyroidectomy with a modified radical neck dissection. Serum CA 19-9 level decreased to the normal range after surgery. Although there have been few reports of patients with elevated serum CA 19-9 levels due to papillary thyroid carcinoma, this is the first report showing such an association in Korea. Thyroid cancer should be considered when the causes of elevated serum CA 19-9 are unclear.
참고문헌 (9)
- 박주경, "수술 불가능한 췌장암 환자에서 생존율 및 예후 인자 분석", 대한내과학회지, 72(2), pp.151~161 (2007), 대한내과학회
- Goonetilleke KS, "Systematic review of carbohydrate antigen(CA 19-9)as a biochemical marker in the diagnosis of pancreatic cancer", Eur J Surg Oncol, 33, pp.266~270 (2007)
- Atkinson BF, "Gastrointestinal cancer-associated antigen in immunoperoxidase assay", Cancer Res, 42, pp.4820~4823 (1982)
- Matsuura B, "Serum levels and thyroid tissue expression of CA50 and CA 19-9 in patients with thyroid tumor", Endocrinol Jpn, 38, pp.565~571 (1991)
- Ogawa M, "Anaplastic transformation from papillary thyroid carcinoma with increased serum CA19-9", Pediatr Blood Cancer, 45, pp.64~67 (2005)
- Vierbuchen M, "CA 50 and CA 19-9 antigen expression in normal, hyperplastic, and neoplastic thyroid tissue", Lab Invest, 60, pp.726~732 (1989)
- Kim JE, "Clinical usefulness of carbohydrate antigen 19-9 as a screening test for pancreatic cancer in an asymptomatic population", J Gastroenterol Hepatol, 19, pp.182~186 (2004)
- Safi F, "Tumor markers in pancreatic cancer : sensitivity and specificity of CA 19-9", Hepatogastroenterology, 36, pp.419~423 (1989)
- Larena A, "Blood group antigen expression in malignant tumors of the thyroid : a parallel between medullary and nonmedullary carcinomas", Langenbecks Arch Chir, 380, pp.269~272 (1995)