에탐부톨에 의한 급성 신질환 1예
Case of Acute Kidney Injury in a Patient with Pulmonary Tuberculosis Receiving Ethambutol Therapy
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초록
Ethambutol is commonly used as a first-line drug for the treatment of tuberculosis. The most serious adverse effect of ethambutoltherapy is optic neuropathy. However, ethambutol-induced acute kidney injury is extremely rare. We report herein a case of acutekidney injury secondary to ethambutol-associated acute interstitial nephritis. A 65-year-old man with pulmonary tuberculosispresented with a > 7-day history of nausea and vomiting. He had begun antituberculosis medications including ethambutol 3 weekspreviously. His laboratory findings showed elevated blood urea nitrogen and serum creatinine levels (32.6 and 3.6 mg/dL,respectively). Examination of percutaneous renal biopsy specimens showed diffuse interstitial mononuclear cell infiltration withmild interstitial edema. The patient was treated by cessation of ethambutol and supportive care. His renal function completely recovered(creatinine, 1.1 mg/dL) and his clinical symptoms improved.
Abstract
Ethambutol is commonly used as a first-line drug for the treatment of tuberculosis. The most serious adverse effect of ethambutoltherapy is optic neuropathy. However, ethambutol-induced acute kidney injury is extremely rare. We report herein a case of acutekidney injury secondary to ethambutol-associated acute interstitial nephritis. A 65-year-old man with pulmonary tuberculosispresented with a > 7-day history of nausea and vomiting. He had begun antituberculosis medications including ethambutol 3 weekspreviously. His laboratory findings showed elevated blood urea nitrogen and serum creatinine levels (32.6 and 3.6 mg/dL,respectively). Examination of percutaneous renal biopsy specimens showed diffuse interstitial mononuclear cell infiltration withmild interstitial edema. The patient was treated by cessation of ethambutol and supportive care. His renal function completely recovered(creatinine, 1.1 mg/dL) and his clinical symptoms improved.
참고문헌 (10)
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