독사조신 복용 후 발생한 여성형유방증 1예
A Case of Gynecomastia Induced by Use of Doxazosin
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초록
남성의 유방이 유선조직의 증식과 지방조직이 축적되어 커지는 것을 여성형유방증이라고 한다. 여성형유방증은 일반적으로 신생아와 청소년기에 흔하게 관찰된다. 하지만 성인 남성, 특히 노인에게서도 발견될 수 있고 최대 65%까지도 보고되고 있다. 여성형유방증의 10-25%는 약에 의해서 발생하고, 이는 프로락틴 분비를 증가시키거나 에스트로겐과 안드로겐 사이의 불균형을 통해 일어난다[1].
Abstract
Doxazosin is an adrenergic alpha-1 receptor antagonist used to treat lower urinary tract symptoms that are common in prostatic hyperplasia. To our knowledge, few cases of gynecomastia and mastodynia, as a complication of adrenergic alpha-1 receptor antagonist, have been reported to date; no cases have been reported in Korea. We describe a case involving a 78-year-old man treated for prostatic hyperplasia with 13 months of doxazosin. He complained about unilateral gynecomstia and mastodynia. Five months after the discontinuation of doxazosin, the gynecomastia was significantly improved. This is the first reported case of gynecomastia and mastodynia associated with doxazosin use in Korea.
참고문헌 (10)
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