Gynecomastia in adolescent males: current understanding of its etiology, pathophysiology, diagnosis, and treatment
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초록
Gynecomastia (GM) is a common and continuously evolving condition that commonly occurs during adolescence. It is the source of significant embarrassment and psychological stress in adolescent males. GM is characterized by enlargement of the male breast due to the proliferation of glandular ducts and stromal components. The main cause of GM during adolescence is physiological or pubertal GM, which is primarily attributed to an imbalance between estrogen and androgen activity. Physiological GM is typically transient and resolves within several months, although it may take several years to resolve. GM may also be caused by other pathological conditions and could be indicative of an endocrine disease. It is crucial to understand the pathogenesis of GM to distinguish it from normal developmental variants due to pathological causes. The aim of this review is to highlight the significance of GM during adolescence in terms of potential etiologies, clinical and laboratory diagnoses, and current management.
Abstract
Gynecomastia (GM) is a common and continuously evolving condition that commonly occurs during adolescence. It is the source of significant embarrassment and psychological stress in adolescent males. GM is characterized by enlargement of the male breast due to the proliferation of glandular ducts and stromal components. The main cause of GM during adolescence is physiological or pubertal GM, which is primarily attributed to an imbalance between estrogen and androgen activity. Physiological GM is typically transient and resolves within several months, although it may take several years to resolve. GM may also be caused by other pathological conditions and could be indicative of an endocrine disease. It is crucial to understand the pathogenesis of GM to distinguish it from normal developmental variants due to pathological causes. The aim of this review is to highlight the significance of GM during adolescence in terms of potential etiologies, clinical and laboratory diagnoses, and current management.
참고문헌 (48)
- Deepinder F, "Gynecomastia : incidence, causes and treatment", Expert Rev Endocrinol Metab, 6, pp.723~730 (2011)
- Rahmani S, "Overview of gynecomastia in the modern era and the Leeds Gynaecomastia Investigation algorithm", Breast J, 17, pp.246~255 (2011)
- Todorova ZP, "Causes and psychological impact of gynecomastia in boys and adolescents", Endokrynol Pol, 72, pp.670~671 (2021)
- Braunstein GD, "Gynecomastia", N Engl J Med, 328, pp.490~495 (1993)
- Bembo SA, "Gynecomastia : its features, and when and how to treat it", Cleve Clin J Med, 71, pp.511~ (2004)
- Ma NS, "Gynecomastia in prepubertal and pubertal men", Curr Opin Pediatr, 20, pp.465~467 (2008)
- Mathur R, "Gynecomastia : pathomechanisms and treatment strategies", Horm Res, 48, pp.95~10 (1997)
- Soliman AT, "Management of adolescent gynecomastia : an update", Acta Biomed, 88, pp.204~213 (2017)
- Bidlingmaier F, "Plasma testosterone and estrogens in pubertal gynecomastia", Z Kinderheilkd, 115, pp.89~89 (1973)
- Ruan W, "Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development", Endocrinology, 140, pp.5075~5081 (1999)
- Yazici M, "Evaluation of breast enlargement in young males and factors associated with gynecomastia and pseudogynecomastia", Ir J Med Sci, 179, pp.575~583 (2010)
- Sansone A, "Gynecomastia and hormones", Endocrine, 55, pp.37~44 (2017)
- Simon BE, "Classification and surgical correction of gynecomastia", Plast Reconstr Surg, 51, pp.48~52 (1973)
- Kanakis GA, "EAA clinical practice guidelinesgynecomastia evaluation and management", Andrology, 7, pp.778~793 (2019)
- Lorek M, "Clinical and biochemical phenotype of adolescent males with gynecomastia", J Clin Res Pediatr Endocrinol, 11, pp.388~394 (2019)
- Shozu M, "Understanding the pathological manifestations of aromatase excess syndrome : lessons for clinical diagnosis", Expert Rev Endocrinol Metab, 9, pp.397~409 (2014)
- Fukami M, "Aromatase excess syndrome : a rare autosomal dominant disorder leading to pre-or peri-pubertal onset gynecomastia", Pediatr Endocrinol Rev, 11, pp.298~305 (2014)
- Nuttall FQ, "Gynecomastia and drugs : a critical evaluation of the literature", Eur J Clin Pharmacol, 71, pp.569~578 (2015)
- Henley DV, "Prepubertal gynecomastia linked to lavender and tea tree oils", N Engl J Med, 356, pp.479~485 (2007)
- Goh SY, "Gynaecomastia and the herbal tonic"Dong Quai"", Singapore Med J, 42, pp.115~116 (2001)
- Braunstein GD, "Environmental gynecomastia", Endocr Pract, 14, pp.409~411 (2008)
- Cuhaci N, "Gynecomastia : clinical evaluation and management", Indian J Endocrinol Metab, 18, pp.150~158 (2014)
- Singer-Granick CJ, "Gynecomastia and Klinefelter syndrome", Eplasty, 15, pp.ic61~ (2015)
- Butler G, "Incidence of gynaecomastia in Klinefelter syndrome adolescents and outcome of testosterone treatment", Eur J Pediatr, 180, pp.3201~3207 (2021)
- Wasniewska M, "11-Hydroxylase deficiency as a cause of prepubertal gynecomastia", J Endocrinol Invest, 32, pp.387~388 (2009)
- Kadair RG, ""Masked"21-hydroxylase deficiency of the adrenal presenting with gynecomastia and bilateral testicular masses", Am J Med, 62, pp.278~282 (1977)
- Mohammadnia N, "Gynecomastia as a presenting symptom of Graves' disease in a 49-year-old man", Endocrinol Diabetes Metab Case Rep, 2021, pp.20~0181 (2021)
- Kannan S, "A curious case of gynaecomastia!", Thyroid Res Pract, 11, pp.116~117 (2014)
- Fideleff HL, "Prolactinoma in children and adolescents", Horm Res Paediatr, 72, pp.197~205 (2009)
- Johnson RE, "Gynecomastia : pathophysiology, evaluation, and management", Mayo Clin Proc, 84, pp.1010~1015 (2009)
- Lee SW, "Partial androgen insensitivity syndrome presenting with gynecomastia", Endocrinol Metab(Seoul), 30, pp.226~230 (2015)
- Kirby RX, "Diabetic mastopathy : an uncommon complication of diabetes mellitus", Case Rep Surg, 2013, pp.198502~ (2013)
- Ely KA, "Diabetic mastopathy : a clinicopathologic review", Am J Clin Pathol, 113, pp.541~545 (2000)
- Derkacz M, "Gynecomastia—a difficult diagnostic problem", Endokrynol Polska, 62, pp.190~202 (2011)
- Nordt CA, "Gynecomastia in adolescents", Curr Opin Pediatr, 20, pp.375~382 (2008)
- Chentli F, "Feminizing adrenocortical tumors : Literature review", Indian J Endocrinol Metab, 19, pp.332~339 (2015)
- Farida C, "Feminizing adrenal tumors : Our experience about three cases", Indian J Endocrinol Metab, 17, pp.509~513 (2013)
- Flaherty DC, "Breast cancer in male adolescents and young adults", Ann Surg Oncol, 24, pp.84~90 (2017)
- Brinton LA, "Breast cancer risk among patients with Klinefelter syndrome", Acta Paediatrica, 100, pp.814~818 (2011)
- Ibrahim M, "Male BRCA mutation carriers : clinical characteristics and cancer spectrum", BMC Cancer, 18, pp.179~ (2018)
- Al Qassabi SS, "Mixed gynecomastia", Saudi Med J, 36, pp.1115~1117 (2015)
- Berger O, "Gynecomastia : a systematic review of pharmacological treatments", Front Pediatr, 10, pp.978311~ (2022)
- Lawrence SE, "Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia", J Pediatr, 145, pp.71~76 (2004)
- Akgül S, "The histopathological effects of tamoxifen in the treatment of pubertal gynecomastia", J Pediatr Endocrinol Metab, 25, pp.753~755 (2012)
- Atabek ME, "Gynecomastia in puberty is usually asymptomatic and regresses spontaneously", J Pediatr Endocrinol Metab, 26, pp.605~ (2013)
- Swerdloff RS, "Endotext" (2000), MDText.com, Inc
- Barros AC, "Gynecomastia : physiopathology, evaluation and treatment", Sao Paulo Med J, 130, pp.187~197 (2012)
- Varlet F, "Pediatric endoscopic subcutaneous mastectomy(pesma)with liposuction in adolescents with gynecomastia", Surg Endosc, 37, pp.766~773 (2023)
