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병리 진단 과정 및 결과 해석 - 면역조직화학염색을 중심으로

The Pathological Diagnosis and Interpretation of Pathological Results: Emphasis on Immunohistochemical Staining

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초록

Hematoxylin and eosin staining is simple and one of the most important techniques in pathological diagnosis. However, it cannot provide complete information about the disease of a patient. Immunohistochemical staining (IHC) is an important method for demonstrating the distribution of a certain molecule or antigen in tissues using specific antigen-antibody reactions. It is used in routine diagnostic work and research to explore biomarkers. In this review, I aim to provide an adequate interpretation of the results of IHC and pathological diagnosis for clinicians.

Abstract

Hematoxylin and eosin staining is simple and one of the most important techniques in pathological diagnosis. However, it cannot provide complete information about the disease of a patient. Immunohistochemical staining (IHC) is an important method for demonstrating the distribution of a certain molecule or antigen in tissues using specific antigen-antibody reactions. It is used in routine diagnostic work and research to explore biomarkers. In this review, I aim to provide an adequate interpretation of the results of IHC and pathological diagnosis for clinicians.

참고문헌 (9)

  1. The Korean Society of Pathologists, "Textbook of Pathology" (2010), Komoonsa
  2. Rosai M, "Rosai and Ackerman’s surgical pathology" (2011), Elsevier
  3. Korea Institute of Clinical Pathology Professor, "Histotechnology" (2006), Korea Medical Book Publishing Company
  4. Kim JY, "Cytology for microscopic diagnosis" (2006), Shinkwang
  5. Kumar V, "Robbins and Cotran Pathologic Basis of Disease" (2015), Elsevier
  6. 박찬식, "Immunohistochemistry for Pathologists: Protocols, Pitfalls, and Tips", Journal of Pathology and Translational Medicine, 50(6), pp.411~418 (2016), 대한병리학회[DOI]
  7. Pekmezci M, "The effect of cold ischemia time and", or formalin fixation on estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 results in breast carcinoma, 2012, pp.2012, 947041~
  8. Phillips T, "Development of standard estrogen and progesterone receptor immunohistochemical assays for selection of patients for antihormonal therapy", Appl Immunohistochem Mol Morphol, 15, pp.325~331 (2007)
  9. Shackelford C, "Qualitative and quantitative analysis of nonneoplastic lesions in toxicology studies", Toxicol Pathol, 30, pp.93~96 (2002)

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