한국임상암학회 전이성 전립선암 치료 지침
Korean Treatment Guidelines for Metastatic Prostate Cancer Developed by the Korean Association for Clinical Oncology
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참고문헌
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초록
한국임상암학회의 전이성 전립선암의 치료지침 개발의목적은 1) 치료지침 개발 과정을 통해 전문가 간의 관련 의학지식 및 경험을 공유하는 기회가 되고, 2) 실제 진료를 담당하는 의료진에게는 종양학적 원칙에 입각한 실제적인 표준 치료 정보를 제공하여, 3) 환자에게 최선의 결과를 가져올수 있는 다학제 진료가 진행성 전립선암에서 잘 정착되도록도모하며, 4) 환자와 일반인에게는 실제적이고 표준적인 의학 정보를 제공하여 담당 의료진과 충분히 상의 후 최적의치료 방법을 결정하는 데 도움을 주고자 한다. 본 지침의 활용 및 보급의 통해 국내 전이성 전립선암의 치료 수준을 향상시키고 이를 통하여 환자의 생명을 연장하고 삶의 질을 개선하여 국민 보건 향상에 이바지하고자 한다. 본 치료지침은 실제 환자를 보는 의료진이 쉽게 이해할수 있도록 하기 위하여 교과서적 기술보다는 분야별 구체적인 핵심질문을 통한 근거 중심의 표준 권고안을 작성하고 근거의 질과 권고의 강도를 제시한 포괄적인 치료지침이다.
Abstract
The management of advanced prostate cancer has evolved rapidly. Androgen deprivation therapy, via surgical or medical castration, is the first-line therapy for hormone-naïve metastatic prostate cancer. For approximately a decade, docetaxel-based chemotherapy was the only approved agent to show a survival benefit for castration-resistant prostate cancer. However, over the last 5 years, significant advances in the field have led to the approval of several new agents with different mechanisms of action, such as the new androgen pathway inhibitors abiraterone and enzalutamide, a new cytotoxic agent, cabazitaxel, and new bone-seeking agents such as radium-223, which have all been associated with improved quality of life and pain palliation and an increase in survival. However, there has been no Korean treatment guideline for metastatic prostate cancer which is developed based on thorough search for relevant articles, including recently developed agents, and adequate review and assessment of evidences, and thus, a guideline adequate for domestic circumstance is eagerly needed. Experts from the Genitourinary Oncology Committee of the Korea Cancer Study Group developed clinical recommendations for the treatment of metastatic prostate cancer based on 19 key questions. The Korean Association for Clinical Oncology, the Korean Prostate Society, the Korean Urological Oncology Society, and the Korean Society of Pathologists reviewed and endorsed the guidelines. These are the first Korean treatment guidelines developed specifically for metastatic prostate cancer.
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