본문 바로가기
KERD
논문KCI 등재

골수증식 종양의 2017년 WHO 진단기준 주요 변경 사항의 이해

Major Changes to the 2017 Revision of the World Health Organization Classification of Myeloproliferative Neoplasms

1

조회

0

다운로드

2

인용

0

참고문헌

키워드

주제분류내과학

초록

The World Health Organization (WHO) Classification of Tumors of Haematopoietic and Lymphoid Tissues was recently published in a revised fourth edition. The categories of myeloproliferative neoplasms (MPNs) have not significantly changed since the 2008 fourth edition of the classification; however, newly discovered mutations including CALR and CSF3R and improved characterizations and standardizations of morphological features of some entities, particularly BCR-ABL1-negative MPNs, have impacted the diagnostic criteria of disease entities, increasing the reliability and reproducibility of diagnoses. The 2017 revised edition attempts to incorporate new clinical, prognostic, morphologic, and genetic data that have emerged since the last edition. This article reviews the major changes in the classification and their rationale for MPN classification within the revised 2017 WHO system.

Abstract

The World Health Organization (WHO) Classification of Tumors of Haematopoietic and Lymphoid Tissues was recently published in a revised fourth edition. The categories of myeloproliferative neoplasms (MPNs) have not significantly changed since the 2008 fourth edition of the classification; however, newly discovered mutations including CALR and CSF3R and improved characterizations and standardizations of morphological features of some entities, particularly BCR-ABL1-negative MPNs, have impacted the diagnostic criteria of disease entities, increasing the reliability and reproducibility of diagnoses. The 2017 revised edition attempts to incorporate new clinical, prognostic, morphologic, and genetic data that have emerged since the last edition. This article reviews the major changes in the classification and their rationale for MPN classification within the revised 2017 WHO system.

참고문헌 (36)

  1. Swerdlow SH, "WHO classification of tumours of haematopoietic and lymphoid tissues" (2017), IARC Press
  2. Tefferi A, "Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myelofibrosis", Blood, 124, pp.2507~2513 (2014)[DOI]
  3. Tefferi A, "An overview on CALR and CSF3R mutations and a proposal for revision of WHO diagnostic criteria for myeloproliferative neoplasms", Leukemia, 28, pp.1407~1413 (2014)[DOI]
  4. Barbui T, "Myeloproliferative neoplasms: morphology and clinical practice", Am J Hematol, 91, pp.430~433 (2016)[DOI]
  5. Gianelli U, "Reproducibility of the WHO histological criteria for the diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms", Mod Pathol, 27, pp.814~822 (2014)[DOI]
  6. Gisslinger H, "Anagrelide compared with hydroxyurea in WHO-classified essential thrombocythemia: the ANAHYDRET study, a randomized controlled trial", Blood, 121, pp.1720~1728 (2013)[DOI]
  7. Madelung AB, "World Health Organization-defined classification of myeloproliferative neoplasms: morphological reproducibility and clinical correlations--the Danish experience", Am J Hematol, 88, pp.1012~1016 (2013)[DOI]
  8. Thiele J, "Essential thrombocythemia versus early primary myelofibrosis: a multicenter study to validate the WHO classification", Blood, 117, pp.5710~5718 (2011)[DOI]
  9. Barbui T, "Masked polycythemia vera (mPV): results of an international study", Am J Hematol, 89, pp.52~54 (2014)[DOI]
  10. Barosi G, "Evidence that prefibrotic myelofibrosis is aligned along a clinical and biological continuum featuring primary myelofibrosis", PLoS One, 7, pp.e35631~ (2012)[DOI]
  11. Gianelli U, "Cooperation between pathologists and clinicians allows a better diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms", Expert Rev Hematol, 7, pp.255~264 (2014)[DOI]
  12. Gisslinger H, "Clinical impact of bone marrow morphology for the diagnosis of essential thrombocythemia: comparison between the BCSH and the WHO criteria", Leukemia, 30, pp.1126~1132 (2016)[DOI]
  13. Byun JM, "Real world epidemiology of myeloproliferative neoplasms: a population based study in Korea 2004-2013", Ann Hematol, 96, pp.373~381 (2017)[DOI]
  14. 최철원, "Guidelines for the management of myeloproliferative neoplasms", The Korean Journal of Internal Medicine, 30(6), pp.771~788 (2015), 대한내과학회[DOI]
  15. Hanfstein B, "Response-related predictors of survival in CML", Ann Hematol, 94(Suppl 2), pp.S227~S239 (2015)[DOI]
  16. Rea D, "First-line imatinib mesylate in patients with newly diagnosed accelerated phase-chronic myeloid leukemia", Leukemia, 26, pp.2254~2259 (2012)[DOI]
  17. Fabarius A, "Impact of additional cytogenetic aberrations at diagnosis on prognosis of CML: long-term observation of 1151 patients from the randomized CML Study IV", Blood, 118, pp.6760~6768 (2011)[DOI]
  18. Maxson JE, "Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML", N Engl J Med, 368, pp.1781~1790 (2013)[DOI]
  19. Pardanani A, "CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia", Leukemia, 27, pp.1870~1873 (2013)[DOI]
  20. Dong F, "The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia", acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation, 2001, pp.167, 6447~6452
  21. Cui Y, "CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia", J Hematol Oncol, 7, pp.77~ (2014)[DOI]
  22. Elliott MA, "Chronic neutrophilic leukemia 2016: update on diagnosis, molecular genetics, prognosis, and management", Am J Hematol, 91, pp.341~349 (2016)[DOI]
  23. Lasho TL, "Chronic neutrophilic leukemia with concurrent CSF3R and SETBP1 mutations: single colony clonality studies, in vitro sensitivity to JAK inhibitors and lack of treatment response to ruxolitinib", Leukemia, 28, pp.1363~1365 (2014)[DOI]
  24. Elliott MA, "ASXL1 mutations are frequent and prognostically detrimental in CSF3R-mutated chronic neutrophilic leukemia", Am J Hematol, 90, pp.653~656 (2015)[DOI]
  25. Alvarez-Larran A, "Masked polycythaemia vera: presenting features, response to treatment and clinical outcomes", Eur J Haematol, 96, pp.83~89 (2016)[DOI]
  26. Barbui T, "Masked polycythemia vera diagnosed according to WHO and BCSH classification", Am J Hematol, 89, pp.199~202 (2014)[DOI]
  27. Barbui T, "Discriminating between essential thrombocythemia and masked polycythemia vera in JAK2 mutated patients", Am J Hematol, 89, pp.588~590 (2014)[DOI]
  28. Barbui T, "Essential thrombocythemia with high hemoglobin levels according to the revised WHO classification", Leukemia, 28, pp.2092~2094 (2014)[DOI]
  29. Thiele J, "The 2008 WHO diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis", Curr Hematol Malig Rep, 4, pp.33~40 (2009)[DOI]
  30. Thiele J, "Standardization of bone marrow features--does it work in hematopathology for histological discrimination of different disease patterns?", Histol Histopathol, 20, pp.633~644 (2005)
  31. Thiele J, "Chronic myeloproliferative disorders with thrombocythemia: a comparative study of two classification systems (PVSG, WHO) on 839 patients", Ann Hematol, 82, pp.148~152 (2003)
  32. Kvasnicka HM, "The impact of clinicopathological studies on staging and survival in essential thrombocythemia, chronic idiopathic myelofibrosis, and polycythemia rubra vera", Semin Thromb Hemost, 32(4), pp.362~371 (2006)[DOI]
  33. Thiele J, "Clinicopathological criteria for differential diagnosis of thrombocythemias in various myeloproliferative disorders", Semin Thromb Hemost, 32, pp.219~230 (2006)[DOI]
  34. Tefferi A, "Myeloproliferative neoplasms: molecular pathophysiology, essential clinical understanding, and treatment strategies", J Clin Oncol, 29, pp.573~582 (2011)
  35. Tefferi A, "CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons", Leukemia, 28, pp.1472~1477 (2014)[DOI]
  36. Thiele J, "European consensus on grading bone marrow fibrosis and assessment of cellularity", Haematologica, 90, pp.1128~1132 (2005)

관련 논문AI추천

The 2020 revision of the guidelines for the management of myeloproliferative neoplasms김호영, Chul Won Choi, Chul Won Jung, Hee-Jin Kim, Jinny Park, Jong-Ho Won, Junshik Hong, Ki-Seong Eom, Min Kyoung Kim, Seongsoo Jang, Seung-Hyun Nam, Soo-Jeong Kim, Soo-Mee Bang, Sung Hwa Bae, Sung-Yong Kim, Yeung-Chul Mun대한내과학회 · The Korean Journal of Internal Medicine2021 · 제36권 제1호Philadelphia+ Chronic Myeloid Leukemia with CALR Mutation: A Case Report and Literature Review김경하, 김지은, 김창곤, 원종호, 윤석윤, 이남수, 이민영, 정선영대한암학회 · Cancer Research and Treatment2020 · 제52권 제3호골수증식종양 진단의 발전장미애, 최철원대한내과학회 · 대한내과학회지2016 · 제90권 제4호Incidence, Clinical Features, and Prognostic Impact of CALR Exon 9 Mutations in Essential Thrombocythemia and Primary Myelofibrosis: An Experience of a Single Tertiary Hospital in Korea김신영, 김인숙, 김형회, 박상혁, 송문곤, 신호진, 이선민, 이은엽, 이종윤, 장철훈, Chulhun Ludgerus Chang대한진단검사의학회 · Annals of Laboratory Medicine2015 · 제35권 제2호Recent insights regarding the molecular basis of myeloproliferative neoplasmsChul Won Choi, Mi-Ae Jang대한내과학회 · The Korean Journal of Internal Medicine2020 · 제35권 제1호The 2016 WHO versus 2008 WHO Criteria for the Diagnosis of Chronic Myelomonocytic Leukemia김미향, 김혜련, 문연숙, 박준성, 안정열, 조성란, 한재호, 허정원, 허지영대한진단검사의학회 · Annals of Laboratory Medicine2018 · 제38권 제5호

이 간행물의 다른 논문 (10건)