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Non-invasive Evaluation of Liver Fibrosis

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An evaluation of liver fibrosis severity during the initial examination is essential for the determination of chronic liver disease prognosis. Although liver biopsy is the gold standard for evaluation of liver fibrosis, bleeding can occur. Therefore, several non-invasive approaches have been introduced, including an equation with clinical variables and assessments of liver stiffness (e.g., elastography). Most patients with chronic liver disease can undergo evaluation of liver fibrosis severity without a liver biopsy using these alternative methods.

Abstract

An evaluation of liver fibrosis severity during the initial examination is essential for the determination of chronic liver disease prognosis. Although liver biopsy is the gold standard for evaluation of liver fibrosis, bleeding can occur. Therefore, several non-invasive approaches have been introduced, including an equation with clinical variables and assessments of liver stiffness (e.g., elastography). Most patients with chronic liver disease can undergo evaluation of liver fibrosis severity without a liver biopsy using these alternative methods.

참고문헌 (11)

  1. Wai CT, "A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C", Hepatology, 38, pp.518~526 (2003)
  2. Lin ZH, "Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis : an updated meta-analysis", Hepatology, 53, pp.726~736 (2011)
  3. Xiao G, "Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection : a systemic review and meta-analysis", Hepatology, 61, pp.292~302 (2015)
  4. Sterling RK, "Development of a simple noninvasive index to predict significant fibrosis in patients with HIV", HCV coinfection, 2006, pp.43, 1317~1325
  5. Kim BK, "Validation of FIB-4 and comparison with other simple noninvasive indices for predicting liver fibrosis and cirrhosis in hepatitis B virus-infected patients", Liver Int, 30, pp.546~553 (2010)
  6. Shah AG, "Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease", Clin Gastroenterol Hepatol, 7, pp.1104~1112 (2009)
  7. Sandrin L, "Transient elastography : a new noninvasive method for assessment of hepatic fibrosis", Ultrasound Med Biol, 29, pp.1705~1713 (2003)
  8. Jung Hwan Yu, "Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease: current and future", Clinical and Molecular Hepatology, 29, pp.136~149 (2023), 대한간학회
  9. Kim BK, "Head-to-head comparison between MEFIB, MAST, and FAST for detecting stage 2 fibrosis or higher among patients with NAFLD", J Hepatol, 77, pp.1482~1490 (2022)
  10. 강성희, "KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease", Clinical and Molecular Hepatology, 27(3), pp.363~401 (2021), 대한간학회
  11. The Korean Association for the Study of the Liver, "KASL clinical practice guidelines for management of chronic hepatitis B", Clinical and Molecular Hepatology, 28(2), pp.276~331 (2022), 대한간학회

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