본문 바로가기
KERD
논문KCI 등재

만성 간질환 환자의 간섬유화 평가를 위한 비침습적 검사의 최근 동향

Recent Trends in Noninvasive Tests for Assessing Hepatic Fibrosis in Patients with Chronic Liver Disease

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류내과학

초록

Hepatic fibrosis is a critical factor in predicting hepatocellular carcinoma occurrence and prognosis in patients with liver disease, making its accurate assessment essential for managing chronic liver disease. Traditionally, liver biopsy has been the standard method for evaluating hepatic fibrosis. However, due to its invasive nature and the limitation of sampling only a small portion of the liver, it is not suitable for widespread use in chronic liver disease patients. Recently, there has been growing interest in noninvasive tests for assessing hepatic fibrosis, including imaging techniques and serum biomarkers. These noninvasive tests are being continuously developed and are increasingly being utilized to evaluate the prognosis of chronic liver disease patients and to inform clinical practice. This paper reviews the recent trends in noninvasive methods for assessing hepatic fibrosis in patients with chronic liver disease, based on studies published to date.

Abstract

Hepatic fibrosis is a critical factor in predicting hepatocellular carcinoma occurrence and prognosis in patients with liver disease, making its accurate assessment essential for managing chronic liver disease. Traditionally, liver biopsy has been the standard method for evaluating hepatic fibrosis. However, due to its invasive nature and the limitation of sampling only a small portion of the liver, it is not suitable for widespread use in chronic liver disease patients. Recently, there has been growing interest in noninvasive tests for assessing hepatic fibrosis, including imaging techniques and serum biomarkers. These noninvasive tests are being continuously developed and are increasingly being utilized to evaluate the prognosis of chronic liver disease patients and to inform clinical practice. This paper reviews the recent trends in noninvasive methods for assessing hepatic fibrosis in patients with chronic liver disease, based on studies published to date.

참고문헌 (48)

  1. Kim MN, "KASL clinical practice guidelines for noninvasive tests to assess liver fibrosis in chronic liver disease", Clin Mol Hepatol, 30(Suppl), pp.S5~S105 (2024)
  2. Rosenberg WM, "Serum markers detect the presence of liver fibrosis : a cohort study", Gastroenterology, 127, pp.1704~1713 (2004)
  3. Anstee QM, "Impact of non-invasive biomarkers on hepatology practice : past, present and future", J Hepatol, 76, pp.1362~1378 (2022)
  4. Lee Y, "Diagnostic efficacy of serum asialo α1-acid glycoprotein levels for advanced liver fibrosis and cirrhosis in patients with chronic hepatitis B compared to that in healthy subjects : a prospective study", J Clin Med, 12, pp.712~ (2023)
  5. Lee EY, "Development of a rapid, immunochromatographic strip test for serum asialo alpha1-acid glycoprotein in patients with hepatic disease", J Immunol Methods, 308, pp.116~123 (2006)
  6. Williams AL, "Ratio of serum aspartate to alanine aminotransferase in chronic hepatitis. Relationship to cirrhosis", Gastroenterology, 95, pp.734~739 (1988)
  7. Wai CT, "A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C", Hepatology, 38, pp.518~526 (2003)
  8. Harrison SA, "Development and validation of a simple NAFLD clinical scoring system for identifying patients without advanced disease", Gut, 57, pp.1441~1447 (2008)
  9. Sterling RK, "Development of a simple noninvasive index to predict significant fibrosis in patients with HIV", HCV coinfection, 2006, pp.43, 1317~1325
  10. Angulo P, "The NAFLD fibrosis score : a noninvasive system that identifies liver fibrosis in patients with NAFLD", Hepatology, 45, pp.846~854 (2007)
  11. Harrison SA, "A blood-based biomarker panel(NIS4)for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis : a prospective derivation and global validation study", Lancet Gastroenterol Hepatol, 5, pp.970~985 (2020)
  12. Narimatsu H, "Development of M2BPGi : a novel fibrosis serum glyco-biomarker for chronic hepatitis", cirrhosis diagnostics, 2015, pp.12, 683~693
  13. Shirabe K, "Mac-2 binding protein glycan isomer(M2BPGi)is a new serum biomarker for assessing liver fibrosis : more than a biomarker of liver fibrosis", J Gastroenterol, 53, pp.819~826 (2018)
  14. Daniels SJ, "ADAPT : an algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis", Hepatology, 69, pp.1075~1086 (2019)
  15. Boyle M, "Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease", JHEP Rep, 1, pp.188~198 (2019)
  16. Guha IN, "Noninvasive markers of fibrosis in nonalcoholic fatty liver disease : validating the European Liver Fibrosis Panel and exploring simple markers", Hepatology, 47, pp.455~460 (2008)
  17. Kim SU, "Variability in liver stiffness values from different intercostal spaces", Liver Int, 29, pp.760~766 (2009)
  18. Boursier J, "Learning curve and interobserver reproducibility evaluation of liver stiffness measurement by transient elastography", Eur J Gastroenterol Hepatol, 20, pp.693~701 (2008)
  19. Bercoff J, "Supersonic shear imaging : a new technique for soft tissue elasticity mapping", IEEE Trans Ultrason Ferroelectr Freq Control, 51, pp.396~409 (2004)
  20. Bamber J, "EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 1 : basic principles and technology", Ultraschall Med, 34, pp.169~184 (2013)
  21. Zhang YN, "Liver fibrosis imaging : a clinical review of ultrasound and magnetic resonance elastography", J Magn Reson Imaging, 51, pp.25~42 (2020)
  22. Bureau C, "Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease", Aliment Pharmacol Ther, 27, pp.1261~1268 (2008)
  23. Robic MA, "Liver stiffness accurately predicts portal hypertension related complications in patients with chronic liver disease : a prospective study", J Hepatol, 55, pp.1017~1024 (2011)
  24. Korean Association for the Study of the Liver(KASL), "KASL clinical practice guidelines for management of chronic hepatitis B", Clin Mol Hepatol, 28, pp.276~331 (2022)
  25. Poynard T, "Relative performances of FibroTest, Fibroscan, and biopsy for the as sessment of the stage of liver fibrosis in patients with chronic hepatitis C : a step toward the truth in the absence of a gold standard", J Hepatol, 56, pp.541~548 (2012)
  26. Imbert-Bismut F, "Biochemical markers of liver fibrosis in patients with hepatitis C virus infection : a prospective study", Lancet, 357, pp.1069~1075 (2001)
  27. Voican CS, "Transient elastography alone and in combination with FibroTest® for the diagnosis of hepatic fibrosis in alcoholic liver disease", Liver Int, 37, pp.1697~1705 (2017)
  28. Thiele M, "Accuracy of the enhanced liver fibrosis test vs FibroTest, elastography, and indirect markers in detection of advanced fibrosis in patients with alcoholic liver disease", Gastroenterology, 154, pp.1369~1379 (2018)
  29. Sheptulina A, "Platelet count to spleen diameter ratio non-invasively identifies severe fibrosis and cirrhosis in patients with autoimmune hepatitis", J Gastroenterol Hepatol, 31, pp.1956~1962 (2016)
  30. Corpechot C, "Baseline values and changes in liver stiffness measured by transient elastography are associated with severity of fibrosis and outcomes of patients with primary sclerosing cholangitis", Gastroenterology, 146, pp.970~979 (2014)
  31. Ehlken H, "Validation of transient elastography and comparison with spleen length measurement for staging of fibrosis and clinical prognosis in primary sclerosing cholangitis", PLoS One, 11, pp.e0164224~ (2016)
  32. Suh B, "High liver fibrosis index FIB-4is highly predictive of hepatocellular carcinoma in chronic hepatitis B carriers", Hepatology, 61, pp.1261~1268 (2015)
  33. Jeong J, "Clinical usefulness of noninvasive fibrosis indices for predicting hepatocellular carcinoma in treatment-naïve patients with chronic hepatitis B following entecavir therapy", Hepatol Res, 51, pp.923~932 (2021)
  34. Jeon MY, "Subcirrhotic liver stiffness by FibroScan correlates with lower risk of hepatocellular carcinoma in patients with HBV-related cirrhosis", Hepatol Int, 11, pp.268~276 (2017)
  35. Kim MN, "Transient elastography for significant fibrosis in treatment-naïve CHB patients : a systematic review and meta-analysis", Clin Mol Hepatol, 30(Suppl), pp.S106~S116 (2024)
  36. Yu JH, "Assessment of the postoperative prognosis in patients with hepatocellular carcinoma using transient elastography : a systemic review and meta-analysis", Clin Mol Hepatol, 30(Suppl), pp.S186~S198 (2024)
  37. Singh S, "Liver stiffness is associated with risk of decompensation, liver cancer, and death in patients with chronic liver diseases : a systematic review and metaanalysis", Clin Gastroenterol Hepatol, 11, pp.1573~1584 (2013)
  38. Seo YG, "Fibrosis-4index predicts long-term all-cause, cardiovascular and liver-related mortality in the adult Korean population", Clin Gastroenterol Hepatol, 21, pp.3322~3335 (2023)
  39. Sohn W, "Liver fibrosis scores and risk of liver-related mortality in young adults with chronic hepatitis B : a cohort study", J Viral Hepat, 29, pp.69~77 (2022)
  40. Zhang Y, "FIB-4 index serves as a noninvasive prognostic biomarker in patients with hepatocellular carcinoma : a meta-analysis", Medicine(Baltimore), 97, pp.e13696~ (2018)
  41. Petta S, "Monitoring occurrence of liver-related events and survival by transient elastography in patients with nonalcoholic fatty liver disease and compensated advanced chronic liver disease", Clin Gastroenterol Hepatol, 19, pp.806~815 (2021)
  42. You MW, "A meta-analysis for the diagnostic performance of transient elastography for clinically significant portal hypertension", Ultrasound Med Biol, 43, pp.59~68 (2017)
  43. Berzigotti A, "Non-invasive evaluation of portal hypertension using ultrasound elastography", J Hepatol, 67, pp.399~411 (2017)
  44. Shi KQ, "Transient elastography : a meta-analysis of diagnostic accuracy in evaluation of portal hypertension in chronic liver disease", Liver Int, 33, pp.62~71 (2013)
  45. Maurice JB, "Validation of the baveno VI criteria to identify low risk cirrhotic patients not requiring endoscopic surveillance for varices", J Hepatol, 65, pp.899~905 (2016)
  46. Marot A, "Liver stiffness and platelet count for identifying patients with compensated liver disease at low risk of variceal bleeding", Liver Int, 37, pp.707~716 (2017)
  47. European Association for the Study of the Liver, "EASL clinical practice guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021update", J Hepatol, 75, pp.659~689 (2021)
  48. Yu JH, "Noninvasive imaging biomarkers for liver fibrosis in nonalcoholic fatty liver disease : current and future", Clin Mol Hepatol, 29(Suppl), pp.S136~S149 (2023)

관련 논문AI추천

이 간행물의 다른 논문 (6건)