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비결핵항산균 폐질환의 면역 발병 기전

Immunopathogenesis of Non-Tuberculous Mycobacteria Lung Disease

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초록

In recent years, the incidence and prevalence of non-tuberculous mycobacteria lung disease (NTM-LD) has been increasing worldwide. In Korea, Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex account for most common cause of NTM-LD. It is essential to elucidate the pathophysiology of NTM-LD. The pathophysiology of NTM-LD has not been fully understood, however, it can be divided into bacterial and host-side factor. Among the host factor, innate immunity plays an essential role in the initial host immune response against intracellular non-tuberculous mycobacteria (NTM), and adaptive immunity also has a role. However, the role of these immunity in mycobacterial disease has been mainly studied in tuberculosis, but studies on its role in NTM are limited. In this review, I focus on NTM innate and adaptive immunity, the role of macrophages and neutrophils, and host interaction in NTM infection.

Abstract

In recent years, the incidence and prevalence of non-tuberculous mycobacteria lung disease (NTM-LD) has been increasing worldwide. In Korea, Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex account for most common cause of NTM-LD. It is essential to elucidate the pathophysiology of NTM-LD. The pathophysiology of NTM-LD has not been fully understood, however, it can be divided into bacterial and host-side factor. Among the host factor, innate immunity plays an essential role in the initial host immune response against intracellular non-tuberculous mycobacteria (NTM), and adaptive immunity also has a role. However, the role of these immunity in mycobacterial disease has been mainly studied in tuberculosis, but studies on its role in NTM are limited. In this review, I focus on NTM innate and adaptive immunity, the role of macrophages and neutrophils, and host interaction in NTM infection.

참고문헌 (71)

  1. Lee H, "Epidemiology of nontuberculous mycobacterial infection, South Korea, 2007-2016", Emerg Infect Dis, 25, pp.569~572 (2019)
  2. Kwon YS, "Diagnosis and treatment of nontuberculous mycobacterial lung disease", J Korean Med Sci, 31, pp.649~659 (2016)
  3. Matsuyama M, "Pathophysiology of pulmonary nontuberculous mycobacterial(NTM)disease", Respir Investig, 61, pp.135~148 (2023)
  4. Abe Y, "Host immune response and novel diagnostic approach to NTM infections", Int J Mol Sci, 21, pp.4351~ (2020)
  5. Honda JR, "Global environmental nontuberculous mycobacteria and their contemporaneous manmade and natural niches", Front Microbiol, 9, pp.2029~ (2018)
  6. Muñoz-Egea MC, "Mycobacterium biofilms", Biofilm, 5, pp.100107~ (2023)
  7. "Pathogenesis of nontuberculous mycobacterial infections" (2023)[URL]
  8. Sousa S, "Nontuberculous mycobacteria pathogenesis and biofilm assembly", Int J Mycobacteriol, 4, pp.36~43 (2015)
  9. Zamora N, "In-vitro evaluation of the adhesion to polypropylene sutures of non-pigmented, rapidly growing mycobacteria", Clin Microbiol Infect, 13, pp.902~907 (2007)
  10. Schorey JS, "The mycobacterial glycopeptidolipids : structure, function, and their role in pathogenesis", Glycobiology, 18, pp.832~841 (2008)
  11. Hall-Stoodley L, "Bacterial biofilms : from the natural environment to infectious diseases", Nat Rev Microbiol, 2, pp.95~108 (2004)
  12. Rhoades ER, "Mycobacterium abscessus glycopeptidolipids mask underlying cell wall phosphatidyl-myo-inositol mannosides blocking induction of human macrophage TNF-alpha by preventing interaction with TLR2", J Immunol, 183, pp.1997~2007 (2009)
  13. Rodríguez-Sevilla G, "Non-tuberculous Mycobacteria multispecies biofilms in cystic fibrosis : development of an in vitro Mycobacterium abscessus and Pseudomonas aeruginosa dual species biofilm model", Int J Med Microbiol, 308, pp.413~423 (2018)
  14. Rodríguez-Sevilla G, "Antimicrobial treatment provides a competitive advantage to Mycobacterium abscessus in a dual-species biofilm with Pseudomonas aeruginosa", Antimicrob Agents Chemother, 63, pp.e01547-19~ (2019)
  15. Honda JR, "Pathogenesis and risk factors for nontuberculous mycobacterial lung disease", Clin Chest Med, 36, pp.1~11 (2015)
  16. Puzo G, "The carbohydrate-and lipid-containing cell wall of mycobacteria, phenolic glycolipids : structure and immunological properties", Crit Rev Microbiol, 17, pp.305~327 (1990)
  17. Tran T, "A paucity of knowledge regarding nontuberculous mycobacterial lipids compared to the tubercle bacillus", Tuberculosis(Edinb), 115, pp.96~107 (2019)
  18. Maeda N, "The cell surface receptor DC-SIGN discriminates between Mycobacterium species through selective recognition of the mannose caps on lipoarabinomannan", J Biol Chem, 278, pp.5513~5516 (2003)
  19. Vignal C, "Lipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-alpha and IL-8 secretion by a CD14-toll-like receptor 2-dependent mechanism", J Immunol, 171, pp.2014~2023 (2003)
  20. Wieland CW, "Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2", Am J Respir Crit Care Med, 170, pp.1367~1374 (2004)
  21. Freeman R, "Roles for cell wall glycopeptidolipid in surface adherence and planktonic dispersal of Mycobacterium avium", Appl Environ Microbiol, 72, pp.7554~7558 (2006)
  22. Byrd TF, "Preliminary characterization of a Mycobacterium abscessus mutant in human and murine models of infection", Infect Immun, 67, pp.4700~4707 (1999)
  23. Sanguinetti M, "Fatal pulmonary infection due to multidrug-resistant Mycobacterium abscessus in a patient with cystic fibrosis", J Clin Microbiol, 39, pp.816~819 (2001)
  24. Torrelles JB, "Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104", Tuberculosis(Edinb), 82, pp.293~300 (2002)
  25. Pedrosa J, "Characterization of the virulence of Mycobacterium avium complex(MAC)isolates in mice", Clin Exp Immunol, 98, pp.210~216 (1994)
  26. Schaefer WB, "Pathogenicity of transparent, opaque, and rough variants of Mycobacterium avium in chickens and mice", Am Rev Respir Dis, 102, pp.499~506 (1970)
  27. Nishimura T, "The rough colony morphotype of Mycobacterium avium exhibits high virulence in human macrophages and mice", J Med Microbiol, 69, pp.1020~1033 (2020)
  28. Sweet L, "Glycopeptidolipids from Mycobacterium avium promote macrophage activation in a TLR2-and MyD88-dependent manner", J Leukoc Biol, 80, pp.415~423 (2006)
  29. Takegaki Y, "Effect of serotype specific glycopeptidolipid(GPL)isolated from Mycobacterium avium complex(MAC)on phagocytosis and phagosome-lysosome fusion of human peripheral blood monocytes", Kekkaku, 75, pp.9~18 (2000)
  30. Cebula BR, "Mycobacterium avium serovars 2 and 8 infections elicit unique activation of the host macrophage immune responses", Eur J Clin Microbiol Infect Dis, 31, pp.3407~3412 (2012)
  31. McGarvey J, "Pathogenesis of nontuberculous mycobacteria infections", Clin Chest Med, 23, pp.569~583 (2002)
  32. Bermudez LE, "Mycobacterium tuberculosis invades and replicates within type II alveolar cells", Infect Immun, 64, pp.1400~1406 (1996)
  33. Lin Y, "Chemokine production by a human alveolar epithelial cell line in response to Mycobacterium tuberculosis", Infect Immun, 66, pp.1121~1126 (1998)
  34. Abbas AK, "핵심면역학" (2020), 법문에듀케이션
  35. Awuh JA, "Molecular basis of mycobacterial survival in macrophages", Cell Mol Life Sci, 74, pp.1625~1648 (2017)
  36. Gordon S, "Phagocytosis : an immunobiologic process", Immunity, 44, pp.463~475 (2016)
  37. Shamaei M, "Nontuberculous Mycobacteria, macrophages, and host innate immune response", Infect Immun, 89, pp.e0081220~ (2021)
  38. Shin DM, "Mycobacterium abscessus activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1", Cell Microbiol, 10, pp.1608~1621 (2008)
  39. Kerscher B, "The dectin-2 family of C-type lectin-like receptors : an update", Int Immunol, 25, pp.271~277 (2013)
  40. Yonekawa A, "Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria", Immunity, 41, pp.402~413 (2014)
  41. Kleinnijenhuis J, "Innate immune recognition of Mycobacterium tuberculosis", Clin Dev Immunol, 2011, pp.405310~ (2011)
  42. Yu X, "Navigating through the maze of TLR2mediated signaling network for better mycobacterium infection control", Biochimie, 102, pp.1~8 (2014)
  43. Sampaio EP, "Mycobacterium abscessus and M. avium trigger Toll-like receptor 2 and distinct cytokine response in human cells", Am J Respir Cell Mol Biol, 39, pp.431~439 (2008)
  44. Lee SJ, "The Mycobacterium avium subsp. Paratuberculosis protein MAP1305 modulates dendritic cell-mediated T cell proliferation through Toll-like receptor-4", BMB Rep, 47, pp.115~120 (2014)
  45. Lee SJ, "Mycobacterium abscessus MAB2560 induces maturation of dendritic cells via Toll-like receptor 4 and drives Th1 immune response", BMB Rep, 47, pp.512~517 (2014)
  46. Shimada K, "Involvement of mannose receptor in glycopeptidolipid-mediated inhibition of phagosome-lysosome fusion", Microbiol Immunol, 50, pp.243~251 (2006)
  47. Kano H, "Serotype-specific modulation of human monocyte functions by glycopeptidolipid(GPL)isolated from Mycobacterium avium complex", Biol Pharm Bull, 28, pp.335~339 (2005)
  48. Roux AL, "The distinct fate of smooth and rough Mycobacterium abscessus variants inside macrophages", Open Biol, 6, pp.160185~ (2016)
  49. Sia JK, "Immunology of Mycobacterium tuberculosis Infections", Microbiol Spectr, 7 (2019)[DOI]
  50. Martin CJ, "Efferocytosis is an innate antibacterial mechanism", Cell Host Microbe, 12, pp.289~300 (2012)
  51. Chen M, "A mechanism of virulence : virulent Mycobacterium tuberculosis strain H37Rv, but not attenuated H37Ra, causes significant mitochondrial inner membrane disruption in macrophages leading to necrosis", J Immunol, 176, pp.3707~3716 (2006)
  52. Behar SM, "Evasion of innate immunity by Mycobacterium tuberculosis : is death an exit strategy?", Nat Rev Microbiol, 8, pp.668~674 (2010)
  53. Early J, "Mycobacterium avium uses apoptotic macrophages as tools for spreading", Microb Pathog, 50, pp.132~139 (2011)
  54. Helguera-Repetto AC, "Differential macrophage response to slow-and fast-growing pathogenic mycobacteria", Biomed Res Int, 2014, pp.916521~ (2014)
  55. Appelberg R, "Host and bacterial factors control the Mycobacterium avium-induced chronic peritoneal granulocytosis in mice", Clin Exp Immunol, 83, pp.231~236 (1991)
  56. Petrofsky M, "Neutrophils from Mycobacterium avium-infected mice produce TNF-alpha, IL-12, and IL-1beta and have a putative role in early host response", Clin Immunol, 91, pp.354~358 (1999)
  57. Bermudez LE, "Treatment with recombinant granulocyte colony-stimulating factor(filgrastin)stimulates neutrophils and tissue macrophages and induces an effective non-specific response against Mycobacterium avium in mice", Immunology, 94, pp.297~303 (1998)
  58. Appelberg R, "Role of gamma interferon and tumor necrosis factor alpha during T-cell-independent and-dependent phases of Mycobacterium avium infection", Infect Immun, 62, pp.3962~3971 (1994)
  59. Kato T, "Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction", J Immunol, 156, pp.3932~3938 (1996)
  60. Altare F, "Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency", Science, 280, pp.1432~1435 (1998)
  61. Dorman SE, "Mutation in the signal-transducing chain of the interferon-gamma receptor and susceptibility to mycobacterial infection", J Clin Invest, 101, pp.2364~2369 (1998)
  62. Flórido M, "Characterization of the deregulated immune activation occurring at late stages of mycobacterial infection in TNF-deficient mice", J Immunol, 179, pp.7702~7708 (2007)
  63. Winthrop KL, "Mycobacterial diseases and antitumour necrosis factor therapy in USA", Ann Rheum Dis, 72, pp.37~42 (2013)
  64. Lim A, "Susceptibility to pulmonary disease due to Mycobacterium avium-intracellulare complex may reflect low IL-17 and high IL-10 responses rather than Th1 deficiency", Clin Immunol, 137, pp.296~302 (2010)
  65. Kim SY, "Importance of reciprocal balance of T cell immunity in Mycobacterium abscessus complex lung disease", PLoS One, 9, pp.e109941~ (2014)
  66. Wu UI, "Patients with idiopathic pulmonary nontuberculous mycobacterial disease have normal Th1", Th2 cytokine responses but diminished Th17 cytokine and enhanced granulocyte-macrophage colony-stimulating factor production, 2019, pp.6, ofz484~
  67. Ratnatunga CN, "The rise of non-tuberculosis mycobacterial lung disease", Front Immunol, 11, pp.303~ (2020)
  68. Greinert U, "Low in vitro production of interferon-gamma and tumor necrosis factor-alpha in HIV-seronegative patients with pulmonary disease caused by nontuberculous mycobacteria", J Clin Immunol, 20, pp.445~452 (2000)
  69. Tsuyuguchi I, "Mycobacterium avium-Mycobacterium intracellular complex-induced suppression of T-cell proliferation in vitro by regulation of monocyte accessory cell activity", Infect Immun, 58, pp.1369~1378 (1990)
  70. Bermudez LE, "Host defense against Mycobacterium avium does not have an absolute requirement for major histocompatibility complex class I-restricted T cells", Infect Immun, 67, pp.3108~3111 (1999)
  71. Gilbertson B, "Anergy, IFN-gamma production, and apoptosis in terminal infection of mice with Mycobacterium avium", J Immunol, 163, pp.2073~2080 (1999)

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