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Polyomavirus(BK Virus) Nephropathy in Kidney Transplant Patients: A Pathologic Perspective

Amr S. Khaled
연세대학교의과대학 (Yonsei University College of Medicine)|2004.12|Yonsei Medical Journal|제45권 제6호|pp. 1065-1075

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참고문헌

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초록

Abstract

Reactivation of polyoma virus (BK virus) is a significant cause of morbidity in kidney transplant patients. This seemingly insignificant viral infection that affects the majority of population at a young age, once reactivated by immunosuppression, is a major factor contributing to graft loss. Screening techniques have been developed for early prediction of BK virus reactivation. These include plasma and urine assays for detection of BK virus DNA by PCR, urine cytology for detection of “decoy cells” and electron microscopy. Combining urine cytology and serology screening can be more effective for early detection of BK virus reactivation. Immunohistochemistry can be utilized as an additional tool to support the diagnosis. Once screening tests reveal a suspicious BK virus reactivation, tissue biopsy should be performed to confirm the diagnosis, rule out acute cellular rejection and plan treatment approaches. Treatment normally includes decreasing immunosuppression and the use of antiviral drug therapy. Unfortunately, disease outcome is often unfavorable and can culminate with eventual graft loss. Renal retransplantation has been performed with mixed results. As new data emerges, we will gain a better understanding of the disease caused by BK virus and respond with improved early diagnosis and treatment to preserve graft function.

참고문헌 (73)

  1. "New human papovavirus (B.K.) isolated from urine after renal transplantation", 1, pp.1253~1257 (1971)
  2. "Molecular Biology of SV40 and the human polyomaviruses BK and JC. In: Klein G, editor. Viral Oncology", pp.489~550 (1980), New York: Raven Press
  3. "Introduction to simian virus 40: getting by with more than a little help from its host cell", 94, pp.3~8 (1998)
  4. "SV40 infections in simians and humans", 94, pp.9~12 (1998)
  5. "New aspects in the pathogenesis of polyomavirus-induced disease", 48, pp.205~261 (1997)
  6. "Polyomaviruses in solid- organ transplant recipients", 74, pp.579~580 (2002)
  7. "Polyomavirus BK", 3, pp.611~623 (2003)
  8. "Molecular biology of BK virus and clinical and basic aspects of BK virus renal infection. In: Khalili K and Stoner GL, editors. Human polyomaviruses: Molecular and clinical perspectives", pp.215~226 (2001), New York: Wiley-Liss
  9. "Polyomavirus BK nephropathy: a (re-) emerging complication in renal transplantation", 2, pp.25~30 (2002)
  10. "BK virus antigenic variants: sequence analysis within the capsid VP1 epitope", 39, pp.50~56 (1993)
  11. "Genomic typing of BK virus in clinical specimens by direct sequencing of polymerase chain reaction products", 1, pp.11~17 (1993)
  12. "The epidemiology of BK virus and the occurence of antigenic and genomic subtypes. In: Khalili K and Stoner GL, editors. Human polyomaviruses: Molecular and clinal perspectives", pp.527~559 (2001), New York: Wiley-Liss
  13. "Seroepidemiology of the human polyomaviruses", 84, pp.1499~1504 (2003)
  14. "Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues", 147, pp.676~684 (1983)
  15. "Activation of human polyomavirus infection-detection by cytologic technics", 74, pp.326~332 (1980)
  16. "Polyoma virus in renal transplant recipients", 29, pp.247~250 (2002)
  17. "Polyomavirus reactivation in native kidneys of pancreas alone allograft recipients", 75, pp.1186~1190 (2003)
  18. "Polyomavirus persistence in lymphocytes: prevalence in lymphocytes from blood donors and healthy personnel of a blood transfusion centre", 81, pp.1967~1973 (2000)
  19. "Latent and persistent polyomavirus infection. In: Khalili K and Stoner GL, editors. Human polyomaviruses: Molecular and clinical perspectives", pp.197~235 (2001), New York: Wiley-Liss
  20. "Nephropathy due to polyomavirus type BK", 342, pp.1361~1363 (2000)
  21. "The high incidence of BK polyoma virus infection among renal transplant recipients in India", 77, pp.429~431 (2004)
  22. "BK polyomavirus interstitial nephritis in a renal allograft recipient", 27, pp.61~64 (2003)
  23. "Differential diagnosis between infection and rejection in renal allografts", 33, pp.1778~1779 (2001)
  24. "Polyoma virus infection after renal transplantation. Use of immunostaining as a guide to diagnosis", 71, pp.896~899 (2001)
  25. "Human polyoma virus- associated interstitial nephritis in the allograft kidney", 67, pp.103~109 (1999)
  26. "Polyomavirus BK infection in pediatric kidney-allograft recipients: a single-center analysis of incidence, risk factors, and novel therapeutic approaches", 75, pp.1266~1270 (2003)
  27. "JC virus enters human glial cells by clathrin-dependent receptor-mediated endocytosis", 74, pp.2288~2292 (2000)
  28. "BK polyoma virus allograft nephropathy: ultrastructural features from viral cell entry to lysis", 3, pp.1383~1392 (2003)
  29. "Polyomavirus disease under new immunosuppressive drugs: a cause of renal graft dysfunction and graft loss", 67, pp.918~922 (1999)
  30. "Incidence of polyomavirus- nephropathy in renal allografts: influence of modern immunosuppressive drugs", 18, pp.1190~1196 (2003)
  31. "Immunosuppression and BKV Nephropathy", 347, pp.2079~2080 (2002)
  32. "Clinical course of polyoma virus nephropathy in 67 renal transplant patients", 13, pp.2145~2151 (2002)
  33. "Transplacental transmission of human polyomavirus BK", 56, pp.372~376 (1988)
  34. "Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy", 342, pp.1309~1315 (2000)
  35. "BK polyoma virus nephropathy in kidney transplant recipient: the role of new immunosuppressive agents", 35, pp.604~605 (2003)
  36. "Human polyomavirus infections with JC virus and BK virus in renal transplant patients", 92, pp.373~378 (1980)
  37. "Real-time quantitative analysis of polyoma BK viremia and viruria in renal allograft recipients", 103, pp.51~56 (2002)
  38. "Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients", 347, pp.488~496 (2002)
  39. "Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine", 74, pp.987~994 (2002)
  40. "A serological investigation of BK virus and JC virus infections in recipients of renal allografts", 158, pp.176~181 (1988)
  41. "Renal transplantation and polyomavirus infection: recent clinical facts and controversies", 5, pp.65~71 (2003)
  42. "Human polyoma virus (HPV)--a significant pathogen in renal transplantation", 15, pp.352~360 (1978)
  43. "Human polyoma virus in renal allograft biopsies: morphological findings and correlation with urine cytology", 30, pp.970~977 (1999)
  44. "Morphological spectrum of polyoma virus disease in renal allografts: diagnostic accuracy of urine cytology", 1, pp.373~381 (2001)
  45. "Utility of urinary cytology for diagnosing human polyoma virus infection in transplant recipients: a study of 37 cases with electron microscopic analysis", 25, pp.376~381 (2001)
  46. "Specific detection of human BK polyomavirus in urine samples of immunocompromised patients", 10, pp.66~69 (2003)
  47. "Polyomavirus BK DNA quantification assay to evaluate viral load in renal transplant recipients", 28, pp.265~274 (2003)
  48. "Polyomavirus BK nephropathy in a kidney transplant recipient: critical issues of diagnosis and management", 38, pp.E13~ (2001)
  49. "Graft dysfunction and polyomavirus infection in renal allograft recipients", 34, pp.809~811 (2002)
  50. "Polyomavirus mimicking high grade transitional cell carcinoma", 156, pp.1764~ (1996)
  51. "Comparative analysis of DNA content in polyomavirus-infected urothelial cells, urothelial dysplasia and high grade transitional cell carcinoma", 19, pp.430~436 (1997)
  52. "JC virus infection in allograft kidneys: analysis by polymerase chain reaction and immunohistochemistry", 71, pp.1300~1303 (2001)
  53. "The first case of JC virus allograft nephropathy", 76, pp.1653~1655 (2003)
  54. "Influence of surveillance renal allograft biopsy on diagnosis and prognosis of polyomavirus-associated nephropathy", 64, pp.665~673 (2003)
  55. "Improved outcome of polyoma virus allograft nephropathy with early biopsy", 36, pp.758~759 (2004)
  56. "Polyomavirus infection of renal allograft recipients: from latent infection to manifest disease", 10, pp.1080~1089 (1999)
  57. "Cynomolgus polyoma virus infection: a new member of the polyoma virus family causes interstitial nephritis, ureteritis, and enteritis in immunosuppressed cynomolgus monkeys", 154, pp.1273~1284 (1999)
  58. "Polyomavirus in kidney and kidney-pancreas transplant recipients", 5, pp.21~28 (2003)
  59. "Glomerular changes in BK virus nephropathy", 35, pp.367~370 (2004)
  60. "BK-related polyomavirus vasculopathy in a renal-transplant recipient", 345, pp.1250~1255 (2001)
  61. "Polyomavirus nephropathy in renal transplantation: a clinico-pathological study", 16, pp.671~675 (2003)
  62. "Histological characteristics of interstitial renal allograft rejection", 21, pp.230~232 (1998)
  63. "BK-virus nephropathy in renal transplants-tubular necrosis, MHC-class II expression and rejection in a puzzling game", 15, pp.324~332 (2000)
  64. "BK transplant nephropathy successfully treated with cidofovir", 18, pp.1013~1014 (2003)
  65. "Treatment of refractory BK virus-associated nephropathy with cidofovir", 3, pp.186~191 (2003)
  66. "Treatment of polyomavirus infection with cidofovir in a renal-transplant recipient", 17, pp.2023~2025 (2002)
  67. "Topical use of cidofovir induced acute renal failure", 73, pp.661~662 (2002)
  68. "Polyomavirus in kidney and kidney-pancreas transplantation: a defined protocol for immunosuppression reduction and histologic monitoring", 34, pp.1788~1789 (2002)
  69. "Retransplantation after kidney graft loss due to polyoma BK virus nephropathy: successful outcome without original allograft nephrectomy", 42, pp.821~825 (2003)
  70. "Retransplantation in patients with graft loss caused by polyoma virus nephropathy", 77, pp.131~133 (2004)
  71. "Renal allograft loss as the result of polyomavirus interstitial nephritis after simultaneous kidney-pancreas transplantation: results with kidney retransplantation", 75, pp.490~494 (2003)
  72. "Recurrent polyomavirus infections in kidney transplants (BK virus nephropathy)", 40, pp.25~28 (2004)
  73. "Successful retransplantation after renal allograft loss to polyoma virus interstitial nephritis", 74, pp.1478~ (2002)

관련 논문AI추천

BK polyomavirus-associated nephropathyAhn Yo Han, Kang Hee Gyung대한소아신장학회 · Childhood Kidney Diseases2022 · 제26권 제1호Cytomegalovirus Induced Interstitial Nephritis and Ureteral Stenosis in Renal Transplant Recipient김용수, 박윤경, 배성하, 양철우, 정병하, 조광훈, 최범순대한내과학회 · The Korean Journal of Internal Medicine2012 · 제27권 제4호Risk factors in the progression of BK virus-associated nephropathy in renal transplant recipients강은진, 김용수, 박철휘, 양철우, 이동재, 이혜민, 장인애, 정병하, 최범순, 최영진대한내과학회 · The Korean Journal of Internal Medicine2015 · 제30권 제6호Urinary Decoy Cell Grading and Its Clinical Implications고명주, 김연희, 노송미, 임범진, 정현주대한병리학회 · Journal of Pathology and Translational Medicine2012 · 제46권 제3호신장이식환자의 인체 Polyoma Virus 감염 진단을 위한 요세포학 및 면역세포화학 검사의 유용성김태전, 한경희대한임상검사과학회 · 대한임상검사과학회지2003 · 제35권 제2호IgA Nephropathy in Renal Allografts-Recurrence and Graft Dysfunction김순일, 김유선, 정현주, 허규하연세대학교의과대학 · Yonsei Medical Journal2004 · 제45권 제6호

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